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All Journal Borneo Journal Of Pharmascientech
Guntur Kurniawan
Program Studi Sarjana Farmasi., Fakultas Farmasi, Universitas Borneo Lestari, Kota Banjarbaru
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan Tingkat Keparahan Efek Samping Obat Anti Tuberkulosis (OAT) Dengan Kepatuhan Minum Obat Pada Pasien Tb Paru Di Puskesmas Tumbang Sangai Guntur Kurniawan; Evy Dharmayanti; Helmina Wati; Weldy Weldy
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 2 (2026): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i2.808

Abstract

Tuberculosis (TB) requires regular treatment over an extended period. Adverse drug reactions (ADRs) to anti-tuberculosis drugs (ATDs) may pose challenges during therapy; therefore, patient monitoring and counseling are essential. This study aimed to analyze the association between the severity of ATD adverse effects and medication adherence among patients with pulmonary TB at Tumbang Sangai Primary Health Center. An analytical observational study with a cross-sectional design was conducted. A total of 32 patients were recruited using accidental sampling. Questionnaires assessing TB drug adverse effects and medication adherence were utilized as research instruments. The results showed that 26 patients (81.3%) experienced severe adverse effects, 3 (9.4%) experienced moderate adverse effects, and 3 (9.4%) experienced mild adverse effects. Regarding medication adherence, 24 patients (75.0%) were classified as adherent, while 8 (25.0%) were classified as non-adherent. Notably, 81.3% of patients experienced severe adverse effects, although the overall medication adherence rate was 75.0%. Statistical analysis using the Fisher-Freeman-Halton exact test revealed a significant association between ATD adverse effects and medication adherence (p = 0.035; p < 0.05). In conclusion, a significant association was found between ATD adverse effects and medication adherence among patients with pulmonary TB at Tumbang Sangai Primary Health Center.
Co-Authors Evy Dharmayanti Helmina Wati Weldy Weldy