Background: Non-communicable diseases (NCDs) are a major public health problem and are associated with modifiable behavioral risk factors. Higher education institutions provide a strategic setting for promoting NCD prevention behaviors from an early age through student-based health promotion. Objective: This study aimed to analyze the effectiveness of a health promotion model based on Muhammadiyah student cadres in preventing NCDs among students of the Faculty of Health Sciences, Universitas Muhammadiyah Mahakarya Aceh. Methods: This quantitative study employed a one-group pretest–posttest design. A total of 30 students participated in measurements before and after the implementation of the health promotion model. The NCD prevention instrument consisted of eight statements. Data were analyzed using the Shapiro–Wilk normality test and a paired-samples t-test. Results: The mean NCD prevention score increased from 6.70 at pretest to 8.37 at posttest, with a mean difference of 1.67 points. The Shapiro–Wilk test indicated that the distribution of difference scores was normal (W = 0.935; p = 0.066). The paired-samples t-test yielded t(29) = 6.774, with p < 0.001 and a 95% confidence interval (CI) of 1.163–2.170. The effect size, measured using Cohen’s dz, was 1.237, indicating a large effect. Conclusion: The health promotion model based on Muhammadiyah student cadres was effective in improving NCD prevention scores among students. This model has the potential to serve as a health promotion and disease prevention strategy to strengthen the implementation of healthy campus initiatives within Muhammadiyah and Aisyiyah Higher Education Institutions (PTMA).
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