<![CDATA[Ocimum sanctum Linn. leaves contain secondary metabolites such as flavonoids, alkaloids, saponins, and tannins that have potential for use as active ingredients in facial toner. Polysorbate 80 is a nonionic surfactant used to improve the dispersion of active ingredients in aqueous preparations. This study aimed to formulate a facial toner containing O. sanctum Linn. leaf extract with variations in Polysorbate 80 concentration (0%, 3%, 5%, and 7%; F0-F3), evaluate its physical quality, and determine the formula with the most suitable physical characteristics. Basil leaves were extracted by maceration using 96% ethanol and tested for moisture content, phytochemical constituents, and residual ethanol before formulation. Physical quality evaluation included organoleptic characteristics, homogeneity, spreadability, pH, viscosity, and skin-irritation testing. Data were analyzed using one-way ANOVA or Kruskal-Wallis according to the distribution and variance characteristics of the data. The extract yield was 6.2%, moisture content was 1.0%, and the extract tested positive for flavonoids, alkaloids, saponins, and tannins. F1, F2, and F3 were homogeneous, whereas F0 was not. Spreadability decreased with increasing Polysorbate 80 concentration (6.95±0.67; 5.55±0.13; 4.25±0.22; and 2.77±0.12 cm for F0-F3), while viscosity increased (56.28±0.28; 65.75±0.69; 69.15±0.32; and 73.65±1.72 cP). All formulas had pH values within the physiological skin range (5.79-6.38), and no signs of irritation were observed in the three volunteers. Polysorbate 80 concentration significantly affected spreadability, pH, and viscosity (p<0.05). F2 (5% Polysorbate 80) showed the most balanced physical characteristics among the tested formulas, although its spreadability was below the specified range.]]>
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