<![CDATA[Background: Diabetes mellitus with persistent hyperglycemia can induce oxidative stress and hepatocellular injury, which may increase serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Objective: This study aimed to evaluate the effect of ethanol extract of cinnamon bark (Cinnamomum burmannii) on SGOT and SGPT levels in streptozotocin-induced diabetic Wistar rats. Methods: An experimental study was conducted using 30 male Wistar rats divided into five groups: negative control, metformin control, and cinnamon bark extract groups at 250, 500, and 750 mg/kg body weight. Treatment was administered for 14 days. SGOT and SGPT were measured enzymatically using a UV-Vis spectrophotometer at 340 nm. Results: Phytochemical screening showed positive results for alkaloids, flavonoids, saponins, steroids/triterpenoids, tannins, and phenolics. Mean SGOT and SGPT values were 250 and 69 U/L in the negative control, 202 and 64 U/L in the metformin group, 327 and 116 U/L at 250 mg/kg, 246 and 119 U/L at 500 mg/kg, and 228.8 and 84.4 U/L at 750 mg/kg. The 750 mg/kg dose produced the lowest mean SGOT and SGPT among the extract groups. Conclusion: These findings indicate that cinnamon bark extract at the highest dose tested showed an improvement in SGOT and SGPT parameters.]]>
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