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All Journal Protein: Jurnal Ilmu Keperawatan dan Kebidanan
Victor Joice Chrisman Mendrofa
Universitas Prima Indonesia
Health Professions Nursing Public Health

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Impact of Cinnamon Bark Extract (Cinnamomum burmannii) on Changes in SGOT and SGPT in Wistar Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus Gusbakti Gusbakti; Victor Joice Chrisman Mendrofa; Dewi Sartika; Sulaiman Delfizar
Protein : Jurnal Ilmu Keperawatan dan Kebidanan.  Vol. 4 No. 4 (2026): Oktober : Protein: Jurnal Ilmu Keperawatan dan Kebidanan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/protein.v4i4.2749

Abstract

Background: Diabetes mellitus with persistent hyperglycemia can induce oxidative stress and hepatocellular injury, which may increase serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Objective: This study aimed to evaluate the effect of ethanol extract of cinnamon bark (Cinnamomum burmannii) on SGOT and SGPT levels in streptozotocin-induced diabetic Wistar rats. Methods: An experimental study was conducted using 30 male Wistar rats divided into five groups: negative control, metformin control, and cinnamon bark extract groups at 250, 500, and 750 mg/kg body weight. Treatment was administered for 14 days. SGOT and SGPT were measured enzymatically using a UV-Vis spectrophotometer at 340 nm. Results: Phytochemical screening showed positive results for alkaloids, flavonoids, saponins, steroids/triterpenoids, tannins, and phenolics. Mean SGOT and SGPT values were 250 and 69 U/L in the negative control, 202 and 64 U/L in the metformin group, 327 and 116 U/L at 250 mg/kg, 246 and 119 U/L at 500 mg/kg, and 228.8 and 84.4 U/L at 750 mg/kg. The 750 mg/kg dose produced the lowest mean SGOT and SGPT among the extract groups. Conclusion: These findings indicate that cinnamon bark extract at the highest dose tested showed an improvement in SGOT and SGPT parameters.
Co-Authors Dewi Sartika Gusbakti Gusbakti Sulaiman Delfizar