PHENOLIC COMPOUND FROM THE STEM BARK OF MANGGIS HUTAN (Garcinia bancana Miq.) AND THEIR ANTIOXIDANT ACTIVITY

Muharni Muharni (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Ogan Ilir, Sumatera Selatan)
Supriyatna Supriyatna (Faculty of Pharmacy, Padjadjaran University, Jatinangor, Sumedang, Indonesia)
Husein H. Bahti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor, Sumedang)
Dachriyanus Dachriyanus (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Andalas University, Limau Manis, Padang)

Indonesian Journal of Chemistry
Vol 9, No 2 (2009)

A phenolic compoud, (-)-epicatechin, was isolated from  the stem bark of Garcinia bancana. The structure of this compound was determined base on spectroscopic  data such as including UV, IR, 1-D, 2-D NMR, and comparison with the reported data. Biological activity of this compound at free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and inhibitory xanthine oxidase(XO) activity showed that (-)- epicathechin active at two methods with IC50 value 8.1 and 8.6 mg/mL respectively.