One-Pot Eco-Safe Saccharin-Catalyzed Procedure for Expedient and Convenient Synthesis of Dihydropyrano[2,3-c]pyrazole, Tetrahydrobenzo[b]pyran and Pyrano[2,3-d]pyrimidinone Scaffolds as a Green and Versatile Catalyst

Farzaneh Mohamadpour (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674 Zahedan, Iran)
Mojtaba Lashkari (Faculty of Science, Velayat University, Iranshahr, Iran)
Nourallah Hazeri (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674 Zahedan, Iran)

Indonesian Journal of Chemistry
Vol 18, No 1 (2018)

A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation reaction. This procedure has the chief advantages of green, inexpensive and readily available catalyst, high atom-economy, high to quantitative yields and the reaction procedure is mild and involves facile workup procedure to obtain the desired products in short reaction times.