Physical Mixture Interaction of Acetaminophenol with Naringenin

Normyzatul Akmal Abd Malek (Atta Ur Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Puncak Alam, Bandar Puncak Alam, 42300, Selangor, Malaysia Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, 40000, Shah Alam, Selangor, Malaysia)
Hamizah Mohd Zaki (Atta Ur Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Puncak Alam, Bandar Puncak Alam, 42300, Selangor, Malaysia Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, 40000, Shah Alam, Selangor, Malaysia)
Mohammad Noor Jalil (Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, 40000, Shah Alam, Selangor, Malaysia)

Indonesian Journal of Chemistry
Vol 18, No 1 (2018)

The interaction of Active Pharmaceutical Ingredient (API) with other compounds will affect drugs stability, toxicity, modified dissolution profiles or may form a new compound with the different crystal structure. Acetaminophenol (APAP), the most common drug used widely (also known as Panadol) was mixed with Naringenin (NR) to glance for a new phase of interactions leading to new compound phase. The amide-acid supramolecular heterosynthon; N-H…O interaction between acid and the respective base were observed in the APAP-NR mixture blends. The interaction was prepared by the binary interaction from neat grinding and liquid-assisted grinding techniques at a different stoichiometry of binary mixture ratio of APAP-NR which were 1:1, 1:2 and 2:1 molar ratio. The interaction was estimated using Group Contribution Method (GCM) and physicochemical properties were characterized by Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR), powder X-ray diffraction (PXRD) and Differential Scanning Calorimetry (DSC) analysis. The GCM calculation gave good interaction strength at 212.93 MPa1/2. The ATR-FTIR, DSC and PXRD results obtained revealed an interaction with new phase formed.