A New Thiourea Compound as Potential Ionophore for Metal Ion Sensor

Fatimatul Akma Awang Ngah (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)
Emma Izzati Zakariah (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)
Imran Fakhar (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)
Nurul Izzaty Hassan (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)
Lee Yook Heng (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)
Bohari Yamin (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)
Siti Aishah Hasbullah (School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia)

Indonesian Journal of Chemistry
Vol 18, No 1 (2018)

A new thiourea compound, 2,2-oxybis(ethyl)-4-(1-naphthyl)-3-thiourea 3 has been synthesized and characterized by using FTIR, 1H-NMR, 13C-NMR, and MS spectroscopy. The binding properties of with various cations were also carried out using ‘naked eye’, UV-vis and 1H-NMR titration experiments. This compound exhibited effective binding for Hg2+ in the presence of other cations, such as Ag+, Ni2+, Sn2+, Zn2+, Fe2+, Cu2+, and Pb2+. Continuous variation titration experiments were conducted in order to determine the binding behavior for Hg2+. Stoichiometry of the host and guest binding interactions were also determined using continuous variation titration experiments and plotting molar-ratio curves. Pearson Product moment method was employed to calculate the correlation coefficient, and non-linear regression equation was used to calculate dissociation constant Kd. Molar-ratio and binding constant data substantiated the presence of binding sites for the compound 3.