Effect of Endurance Treadmill Training on mIGF-1 Expression and PAX 7 Satellite Cell in Rat Muscle Tissues

Mustofa Mustofa (Master Program in Biomedical Science, Faculty of Medicine, University of Brawijaya)
Karyono Mintaroem (Departement of Pathology Anatomy, University of Brawijaya)
Agustina Endharti (Department of Parasitology, Faculty of Medicine, University of Brawijaya Biomedical Central Laboratory, Faculty of Medicine, University of Brawijaya)

Research Journal of Life Science
Vol 5, No 2 (2018)

This study examined the effects of endurance exercise training on muscle Insulin Growth Factor-1 (mIGF-1) and PAX7 transcription factor of satellite cell activation in a tibialis anterior muscle of rat. Rat were subjected to treadmill, divided into three groups, each containing 6 rats. Groups of high, moderate and low doses of exercise received 28, 17 and 12 m/s of treadmill speeds respectively. Treadmill exercise training conducted in 5 days a week within 9 weeks. At the end of 9 weeks of the experiment, rat were sacrificed, tibialis anterior muscle tissues was removed and then subjected to immunohistochemistry examination. There were significant differences in intensity of training in mIGF-1 and PAX7 in muscle tissues (P < 0.05). These results suggested that endurance exercise training which high, moderate and low intensity able to increase mIGF-1 and PAX7 that associates with satellite cell development of muscle tissues.