One-Pot-Multicomponent Synthesis of 2,6-Diamino-4-arylpyridine-3,5-dicarbonitrile Derivatives Using Nanomagnetic Fe3O4@SiO2@ZnCl2

Behrooz Maleki (Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran)
Hadi Natheghi (Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran)
Vahid Sokhanvaran (Faculty of Basic Sciences, University of Neyshabur, Neyshabur, Iran)
Samaneh Sedigh Ashrafi (Department of Chemistry, Faculty of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran)

Indonesian Journal of Chemistry
Vol 18, No 4 (2018)

Nanomagnetic Fe3O4@SiO2@ZnCl2 was used as a simple, cost-effective, and reusable heterogeneous catalyst for the synthesis of 2,6-diamino-4-arylpyridine-3,5-dicarbonitriles by a one-pot-three-component condensation reaction of malononitrile, ammonium acetate, and aldehydes under solvent-free conditions at 110 °C. Simple and mild reaction conditions, facile preparation of the catalyst, the use of a cheap catalyst and easy workup and isolation are notable features of this method.