Systemic sclerosis in two generations family: a mother and offspring

D Nilasari (Rheumatology Division of the Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital)
Laniyati Hamijoyo (Rheumatology Division of the Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital)
Yoga I Kasjmir (Rheumatology Division of the Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital)
Bambang Setiyohadi (Rheumatology Division of the Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital)

Indonesian Journal of Rheumatology
Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology

Systemic sclerosis (SSc) is uncommon connective tissue disease characterized by a pathological thickening and tethering of the skin and involvement of internal organ (i.e gastrointestinal tract, heart, lungs, and kidneys). Systemic sclerosis seems to result from a multifactorial process (alteration of the immune system, genetic, and  environmental factors) but its pathogenesis remains unclear. A familial history of SSc represents an important risk factor for developing the disease.1 We describe two generations family who developed SSc.