Grafting of Heparin on Blend Membrane of Citric Acid Crosslinked Chitosan/Polyethylene Glycol-Poly Vinyl Alcohol (PVA-PEG)

Retno Ariadi Lusiana (Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang 50275, Indonesia)
Ginanjar Argo Pambudi (Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang 50275, Indonesia)
Fitra Nilla Sari (Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang 50275, Indonesia)
Didik Setiyo Widodo (Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang 50275, Indonesia)
Khabibi Khabibi (Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang 50275, Indonesia)
Sri Isdadiyanto (Department of Biology, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. H. Soedarto, S.H., Tembalang, Semarang 50275, Indonesia)

Indonesian Journal of Chemistry
Vol 19, No 1 (2019)

Heparin, an active sulfate group material, grafted onto blend membrane citric acid cross-linked chitosan/poly (vinyl alcohol)-poly(ethylene glycol) (PVA-PEG) to improve the membrane properties. The physical tests shown that grafting reaction of citric acid crosslinked chitosan increased the mechanical strength and membrane swelling. The permeability test results, it was found that the grafted chitosan membrane was improved permeability of both urea and creatinine as compared to chitosan pure and chitosan crosslinked membrane. The negative charge of the sulphonate group of heparin increased the number of the active side of the carrier in the membrane, which then correlated to the membrane’s permeability process.