<![CDATA[Objective: To understand the relationship of heme oxygenase-1
(HO-1) level between normotensive pregnancy and preeclampsia
with severe features.
Method: The cross sectional study was conducted in the Department
of Obstetrics and Gynecology, Faculty of Medicine, Universitas
Sam Ratulangi/Prof. Dr. R. D. Kandou General Hospital Manado. The
subjects consisted of 26 pregnant women with normal blood pressure
and 26 women with severe features of preeclampsia. We took
the patients’ history, general physical examination, and laboratory
assessment. The blood samples were taken from normotensive women
more than 20 weeks of pregnancy and preeclamptic women
with severe features more than 20 weeks of pregnancy. The data obtained
was processed using SPSS 20.0 software. We did the nonparametric
Mann-Whitney test to analyze the relationship between
heme oxygenase-1 (HO-1) level in normotensive pregnancy and
preeclampsia with severe features.
Result: The level of heme oxygenase-1 (HO-1) in normotensive
pregnant women was at 3.24 (SD 0.58) ng/ml (95% CI 3.00-3.47),
and the level of heme oxygenase-1 (HO-1) of preeclamptic women
with severe features was 3.92 (SD 0.73) ng/ml (95% CI 3.62-4.21).
The result of Mann-Whitney test showed p value of 0.001 which
meant that there was significant difference in the level of heme oxygenase-
1 (HO-1) between normotensive women and pre-eclamptic
women with severe features.
Conclusion: There was the relationship between the level of heme
oxygenase-1 (HO-1) and the incidence of preeclampsia with severe
features.
Keywords: heme oxygenase-1 (HO-1), normotensive pregnancy, preeclampsia with severe features]]>
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