Ekspresi Glukosa Transporter 2 Sel Beta Pankreas pada Tikus yang Diinduksi Streptozotocin dan Nikotinamid

Jena Hayu Widyasti (Fakultas Farmasi, Universitas Setia Budi Surakarta)

Jurnal Farmasi Indonesia
Vol 15 No 1 (2018): Jurnal Farmasi Indonesia

Diabetes Mellitus (DM) type II occurs in individual with insulin resistance or β pancreaticcells damage which is not able to respond glucose and produce insulin. Insulin is an importanthormon in glucose transport. Glucose transporter (GLUT-2) in β pancreatic cell membranes isresponsible for glucose transport that will stimulate insulin secretion. The purpose of thisresearch was to the effectson GLUT-2 protein expression in pancreatic β cells ofStreptozotocin-Nicotinamide-induced(STZ-NA) rats.This research performed using two groups of male Wistar rats. Group I was normalcontrol group, while Groups II were induced with STZ-NA. The dosage used in STZ induction is50 mg / kg WB rats and NA 110 mg / kg WB rats. The expression of GLUT-2 protein in βpancreatic cells in rats were observed by using immunohistochemistristy method.The result showed that the density of GLUT-2 protein in β pancreatic cells significantlydecreased in the group STZ-NA-induced rats comparing to normal control group