THE SYNTHESIS OF A NOVEL BIBENZOPYRAN RELIED ON ELECTROOXYDATION OF MALLOAPELTA B BY CYCLIC VOLTAMMETRY

Phan Thi Binh (Institute of Chemistry, VAST)
Bui Hai Ninh (Institute of Chemistry, VAST)
Chau Van Minh (Institute of Natural Products Chemistry, VAST)
Nguyen Hoai Nam (Institute of Natural Products Chemistry, VAST)
Le Mai Huong (Institute of Natural Products Chemistry, VAST)
Phan Van Kiem (Institute of Natural Products Chemistry, VAST)

ASEAN Journal on Science and Technology for Development
Vol. 24 No. 4 (2007): ASEAN Journal on Science and Technology for Development (AJSTD)

A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50: 0.46 µg/m) and rhabdosarcoma (RD; IC50: 0.33 µg/m). These results were the same that of  malloapelta B  (Hep-2, IC50: 0.49 µg/ml and  KB, IC50: 0.54 µg/ml).