Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut

Auzal Halim (Fakultas Farmasi Universitas Andalas Padang)
Reni Daniati (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Rina Wahyuni (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)

Jurnal Farmasi Higea
Vol 5, No 1 (2013)

Microencapsulation of metronidazole using HPMC as a polymer by solvent evaporation method had been studied. Microcapsulhad been made into3formulation with 3 ratio variation between Metronidazole and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were analyzed by SEM, DTA, FT-IR, particle sized distribution and dissolution profile. Microcapsules were white to slightly yellow and almost perfectly spherical.Disolution profiles of microcapsules showed that the greater amount of HPMC gave the slower release ofMetronidazole. Dissolution kinetics of microcapsule allowedHiguchi equation, where the realese of Metronidazole  from microcapsules were controlled by diffution process.