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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi INDONESIAN JOURNAL OF PHARMACY JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea
Auzal Halim
STIFARM Padang
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Penggunaan Eudragit L 100 Dalam Formulasi Mikrokapsul Natrium Diklofenak Dengan Teknik Emulsifikasi-Penguapan Pelarut Rahmadevi, Rahmadevi; Zaini, Erizal; Halim, Auzal
Jurnal Farmasi Andalas Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Andalas

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It has been research about formulation diclofenac sodium that used Eudragit L100. To prepare, using emulsification-solvent evaporation technique, diclofenac sodium-Eudragit L100 microparticles with modified drug sustained release properties and span 80 is emulgator. Methode research is microcapsules were prepared by solvent evaporation method with ratio diclofenac sodium-Eudragit L100 (1:1,125;1:1,25;1:1,5;1:1,75) and characterized by micromeritics, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), dissolution test using USP apparatus 1 and drug Embadment Efficiency. The result is the microparticle were whitish, irregular, aggregated, and in the size range of 100 – 160 µm size. Drug embedment efficiency was 53,7% - 66,3 %. Characterisation studies indicate that there was no chemical interaction between the drug and the polymer in the microparticles. In Dissolution profile ratio diclofenac sodium and Eudragit L100 can slowly drug release were after 450 minute released diclofenac sodium > 50%. Conclusion: Emulsification-solvent evaporation technique is a suitable method for preparing diclofenac sodium-Eudragit L100 multi-unit controlled release drug delivery system.
Pengaruh Ukuran Partikel Terhadap Solubilisasi Metronidazol dengan Menggunakan Brij 35 Febriyenti, Febriyenti; Halim, Auzal; Nelvianti, Nelvianti
Jurnal Farmasi Andalas Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Andalas

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A Study has been done on the effect correlation effect of particle size on solubilization of metronidazol using brij 35 in water solvent. Surface tension method using Torsion Balance Type OS White. Inst. Co. Ltd and refraction method using Refractometer ABBE were done for determination of CMC (Critical Micelle Concentration) values of surfactans with Brij 35. Size of metronidazol particle was reduced by milling process with various duration 0 hour, 1 hour, 6 hours and 12 hours using Ball Mills “The Pascall Engineering”. Result showed that concentration of metronidazol in solubilization was 11,0888 mg/ml, 10,6470 mg/ml, 10,4431 mg/ml and 10,0890 mg/ml respectively at various milling period of 1 hour, 6 hour, 12 hour and without milling. Metronidazol after milling for 1 hour showed better solubilization than without milling with further. The Solubilization of metronidazol decreased with an increase in milling time. The Results at various time of milling process of 1 hour, 6 hours, 12 hours and without miliing. Process found the solubilization of metronidazol concentration were 11,0888 mg/ml, 10,6470 mg/ml, 10,4431 mg/ml and 10,0890 mg/ml. Keywords : Solubilization, Metronidazol, Brij 35, milling
Studi Sistem Dispersi Padat Gliklazid Menggunakan Polivinil Pirolidon K-30 (PVP K-30) dan Tween 80 Halim, Auzal; Shilvi, Aulia; Erizal, Erizal
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Solid dispersions of gliclazide were prepared by solvent evaporation method using PVP K-30 and Tween 80 as dispersion carriers. The  physicochemical characteristics of solid dispersions were evaluated using microscopic analysis, X-ray diffraction, differential thermal analysis, determination of recovery, and dissolution rate test. Difractogram X-rays showed the physical interaction between the drug (gliclazide) and carrier (PVP K-30 and Tween 80), and polymorphic transformation occured during the evaporation of solvent in the preparation of solid dispersion. Thermogram DTA showed that the components of PVP K-30 and Tween 80 used affected the position of endothermic peak and peak sharpness. Determination of gliclazide in the recovery of solid dispersion was done using derivative spectrophotometry. Solid dispersion of gliclazide-PVP K-30-Tween 80 prepared in this study were found to have higher dissolution rates than pure gliclazide.
Studi Sistem Dispersi Padat Isoxsuprine Hcl Povidon K-30 Taslim, Tuty; Halim, Auzal; Suardi, Muslim
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on Solid Dispersion System of Isoxsuprine HCl by using syntetic polymer Povidon K-30 to increase solubility has been done has been done. The solid dispersion system were prepared by using solvent method with any comparison ( Taslim, 2007). Charactheristics of physical chemistry properties of solid dispersion such as dissolution test, X-ray diffraction analysis, Differential Scanning Calorimetry, and Fourier Transform Infra Red were assayed. The dissolution test from solid dispersion by using UV spectrophotometer. Statistical analysis of solid dispersion’s dissolution test was done by using Anova. The characteristic X-ray’s diffraction and FTIR showed that solid dispersion with drug to polimer ratio of 1:9 ; 2:8 ; 3:7 were amorf in comparison to other solid dispersions. Statistical analysis by one direction Anova concluded that the dissolution profile of the solid dispersion system of 2:8 was the highest.
PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 4 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Kofler’s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
Karakterisasi Kompleks Inklusi Simvastatin – β-Siklodekstrin yang Dibuat dengan Metoda Kneading Octavia, Maria Dona; Zaini, Erizal; Halim, Auzal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

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ABSTRACT : Characterization of Inclusion Complex Simvastatin - β - cyclodextrin prepared by Kneading Method" has been done . This study aims to improve the dissolution rate and characterize inclusion complexes simvastatin - β - cyclodextrin developed into 3 formula , the ratio between the simvastatin and β - cyclodextrin following formula I ( 1 : 1 ), the formula II ( 1 : 2 ), and the formula III ( 2 : 1 ). Inclusion complex prepared by adding water solvent to form a paste and then dried at room temperature. The results of the inclusion complexes were characterized by analysis Differential Thermal Analysis ( DTA ), X-ray diffraction, IR spectrophotometry, Scanning Electron Microscopy ( SEM ), and dissolution rate . The results of this analysis indicate that the inclusion complex formed, characterization and dissolution profiles better than the pure simvastatin and mixed physics simvastatin and β - cyclodextrin.   Key words : Inclusion complex, Simvastatin, β-Cyclodextrin, Kneading Methods   ABSTRAK : Telah dilakukan penelitian dengan judul "Karakterisasi Kompleks Inklusi Simvastatin - β-Siklodekstrin yang dibuat dengan Metoda Kneading". Penelitian ini bertujuan untuk meningkatkan laju disolusi serta mengkarakterisasi kompleks inklusi Simvastatin - β-Siklodekstrin yang dikembangkan menjadi 3 formula, dengan perbandingan antara simvastatin dan β - siklodekstrin sebagai berikut formula I (1 : 1), formula II (1 : 2), dan formula III (2 : 1). Komplek inklusi dibuat dengan cara menambahkan pelarut air hingga terbentuk masa seperti pasta dan kemudian dikeringkan pada suhu kamar. Hasil komplek inklusi ini dikarakterisasi dengan analisa Differensial Thermal Analysis (DTA), Difraksi Sinar X, Spektrofotometri Infra Red, Scanning Electron Microscopy (SEM), dan disolusi. Hasil analisa tersebut menunjukkan bahwa kompleks inklusi yang terbentuk memberikan karakterisasi dan profil disolusi yang lebih baik dibandingkan dengan simvastatin murni dan campuran fisika simvastatin dan β-siklodekstrin yang dibuat dengan penggerusan biasa. Kata Kunci : Kompleks inklusi, Simvastatin, β-Siklodekstrin, Metoda Kneading
Uji Sifat Fisikokimia Mocaf (Modified cassava Flour) dan Pati Singkong Termodifikasi untuk Formulasi Tablet Wira Noviana, Wira Noviana; Halim, Auzal; Lucida, Henny
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

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ABSTRACT: Utilization of cassava starch as an excipient in the tablet formulation is still very limited. Various modifications to the cassava starch has been carried out to obtain a better starch properties. The aim of this study was to examine the physi- cochemical properties of MOCAF and modified cassava starch as an excipient for tablet formulation, especially for direct compression method. MOCAF and modified cassava starch is a product of flour and cassava starch is modified mainly by lac- tic acid bacteria (Lactobacillus sp). Then the results of these modifications will be evaluated physicochemical properties, including examination of the surface shape of starch granules using SEM, thermal analysis by DTA, the pattern of starch crys- tallographic by X-ray diffraction, adsorption isotherm, and the content of amylose. The results showed that MOCAF and modified cassava starch granule were rougher- occurred some holes presented distinctively- and more crystalline than Starch 1500. Meanwhile, the result of adsorption isotherms MOCAF and modified cassava starch showed a model type II of adsorption isotherms. Another results show that the amy- lose content of cassava starch modified 48 hours has the highest amylose content that is equal to 33.5714%. Keywords: MOCAF, Modified Cassava Starch, Lactic Acid Bacteria, Tablets ABSTRAK: Penggunaan pati singkong sebagai bahan tambahan dalam formulasi tablet masih sangat terbatas. Berbagai modifikasi terhadap pati singkong telah dilakukan untuk mendapatkan sifat pati yang lebih baik. Tujuan penelitian ini adalah untuk menguji sifat fisikokimia MOCAF dan pati singkong termodifikasi sebagai bahan tambahan dalam formulasi tablet khususnya untuk metoda cetak langsung. MOCAF dan pati singkong termodifikasi merupakan produk tepung dan pati singkong yang dimodifikasi terutama oleh bakteri asam laktat (Lactobacillus sp). Kemudian hasil modifikasi ini akan dievaluasi sifat fisikokimianya, dianta- ranya pemeriksaan bentuk permukaan granula pati menggunakan SEM (Scanning Electron Microscope), analisis panas dengan DTA, pola kristalografi pati dengan difraksi sinar X, adsorpsi isoterm, dan kadar amilosa. Hasilnya menunjukkan bah- wa MOCAF dan pati singkong termodifikasi mengalami perlubangan pada permu- kaan granulanya, dan lebih bersifat kristal jika dibandingkan dengan Starch 1500. Sementara itu, dari hasil pemeriksaan adsorpsi isoterm MOCAF dan pati singkong termodifikasi menunjukkan model adsorpsi isoterm tipe II. Hasil lainnya menun- jukkan bahwa kadar amilosa pati singkong termodifikasi 48 jam mempunyai ka- dar amilosa paling tinggi yaitu sebesar 33,5714%. Kata kunci: MOCAF, Pati Singkong Termodifikasi, Bakteri Asam Laktat, Tablet
Uji Sifat Fisikokimia Mocaf (Modified cassava Flour) dan Pati Singkong Termodifikasi untuk Formulasi Tablet Wira Noviana, Wira Noviana; Halim, Auzal; Lucida, Henny
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.398 KB) | DOI: 10.35617/jfi.v6i3.380

Abstract

ABSTRACT: Utilization of cassava starch as an excipient in the tablet formulation is still very limited. Various modifications to the cassava starch has been carried out to obtain a better starch properties. The aim of this study was to examine the physi- cochemical properties of MOCAF and modified cassava starch as an excipient for tablet formulation, especially for direct compression method. MOCAF and modified cassava starch is a product of flour and cassava starch is modified mainly by lac- tic acid bacteria (Lactobacillus sp). Then the results of these modifications will be evaluated physicochemical properties, including examination of the surface shape of starch granules using SEM, thermal analysis by DTA, the pattern of starch crys- tallographic by X-ray diffraction, adsorption isotherm, and the content of amylose. The results showed that MOCAF and modified cassava starch granule were rougher- occurred some holes presented distinctively- and more crystalline than Starch 1500. Meanwhile, the result of adsorption isotherms MOCAF and modified cassava starch showed a model type II of adsorption isotherms. Another results show that the amy- lose content of cassava starch modified 48 hours has the highest amylose content that is equal to 33.5714%. Keywords: MOCAF, Modified Cassava Starch, Lactic Acid Bacteria, Tablets ABSTRAK: Penggunaan pati singkong sebagai bahan tambahan dalam formulasi tablet masih sangat terbatas. Berbagai modifikasi terhadap pati singkong telah dilakukan untuk mendapatkan sifat pati yang lebih baik. Tujuan penelitian ini adalah untuk menguji sifat fisikokimia MOCAF dan pati singkong termodifikasi sebagai bahan tambahan dalam formulasi tablet khususnya untuk metoda cetak langsung. MOCAF dan pati singkong termodifikasi merupakan produk tepung dan pati singkong yang dimodifikasi terutama oleh bakteri asam laktat (Lactobacillus sp). Kemudian hasil modifikasi ini akan dievaluasi sifat fisikokimianya, dianta- ranya pemeriksaan bentuk permukaan granula pati menggunakan SEM (Scanning Electron Microscope), analisis panas dengan DTA, pola kristalografi pati dengan difraksi sinar X, adsorpsi isoterm, dan kadar amilosa. Hasilnya menunjukkan bah- wa MOCAF dan pati singkong termodifikasi mengalami perlubangan pada permu- kaan granulanya, dan lebih bersifat kristal jika dibandingkan dengan Starch 1500. Sementara itu, dari hasil pemeriksaan adsorpsi isoterm MOCAF dan pati singkong termodifikasi menunjukkan model adsorpsi isoterm tipe II. Hasil lainnya menun- jukkan bahwa kadar amilosa pati singkong termodifikasi 48 jam mempunyai ka- dar amilosa paling tinggi yaitu sebesar 33,5714%. Kata kunci: MOCAF, Pati Singkong Termodifikasi, Bakteri Asam Laktat, Tablet
PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.57

Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Koflerâ??s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
Karakterisasi Kompleks Inklusi Simvastatin – β-Siklodekstrin yang Dibuat dengan Metoda Kneading Octavia, Maria Dona; Zaini, Erizal; Halim, Auzal
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.425 KB) | DOI: 10.35617/jfi.v7i3.179

Abstract

ABSTRACT : Characterization of Inclusion Complex Simvastatin - β - cyclodextrin prepared by Kneading Method" has been done . This study aims to improve the dissolution rate and characterize inclusion complexes simvastatin - β - cyclodextrin developed into 3 formula , the ratio between the simvastatin and β - cyclodextrin following formula I ( 1 : 1 ), the formula II ( 1 : 2 ), and the formula III ( 2 : 1 ). Inclusion complex prepared by adding water solvent to form a paste and then dried at room temperature. The results of the inclusion complexes were characterized by analysis Differential Thermal Analysis ( DTA ), X-ray diffraction, IR spectrophotometry, Scanning Electron Microscopy ( SEM ), and dissolution rate . The results of this analysis indicate that the inclusion complex formed, characterization and dissolution profiles better than the pure simvastatin and mixed physics simvastatin and β - cyclodextrin.   Key words : Inclusion complex, Simvastatin, β-Cyclodextrin, Kneading Methods   ABSTRAK : Telah dilakukan penelitian dengan judul "Karakterisasi Kompleks Inklusi Simvastatin - β-Siklodekstrin yang dibuat dengan Metoda Kneading". Penelitian ini bertujuan untuk meningkatkan laju disolusi serta mengkarakterisasi kompleks inklusi Simvastatin - β-Siklodekstrin yang dikembangkan menjadi 3 formula, dengan perbandingan antara simvastatin dan β - siklodekstrin sebagai berikut formula I (1 : 1), formula II (1 : 2), dan formula III (2 : 1). Komplek inklusi dibuat dengan cara menambahkan pelarut air hingga terbentuk masa seperti pasta dan kemudian dikeringkan pada suhu kamar. Hasil komplek inklusi ini dikarakterisasi dengan analisa Differensial Thermal Analysis (DTA), Difraksi Sinar X, Spektrofotometri Infra Red, Scanning Electron Microscopy (SEM), dan disolusi. Hasil analisa tersebut menunjukkan bahwa kompleks inklusi yang terbentuk memberikan karakterisasi dan profil disolusi yang lebih baik dibandingkan dengan simvastatin murni dan campuran fisika simvastatin dan β-siklodekstrin yang dibuat dengan penggerusan biasa. Kata Kunci : Kompleks inklusi, Simvastatin, β-Siklodekstrin, Metoda Kneading
Co-Authors Adik Ahmadi Agel Sagreatra Amelia Sari, Amelia Aulia Shilvi DELLADARI MAYEFIS Dwi Setyawan Eka Syuryani Elva Yunengsih Elvi Rahma Yulisman Erizal Erizal Erizal Zaini Fathya Intan Lestari, Fathya Intan Helvia Angraeni Henny Lucida Iin Indah Sari Indra Makmur Khairil Armal Maizel Fitri Maria Dona Octavia Maria Dona Oktavia Marlani Marlani Mayariz, Afriza Monica Afrinda Muslim Suardi Nelvianti Nelvianti Oktavia Arianti Rahmadevi Rahmi Purwaningsih Reni Daniati RIDA HALIM Rieke Azhar Rika Indriyani Rina Trifarmila Rina Wahyuni Rini Agustin Rosaini, Henni Salman - Sari Kartika Sri Oktavia Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. SYUKRAN HAMDENI Tuty Taslim Wahyu Margi Sidoretno Wira Noviana, Wira Noviana Wira Noviana, Wira Noviana Yeni Novita Sari Yeyet C. Sumirtapura Yolla Erman Novita Sari Yustina Susi Irawati Zafrul, Addina Zilfia Zilfia