Jurnal Farmasi Higea
Vol 10, No 1 (2018)

Kompleks Inklusi Amlodipin Besilat – β-siklodekstrin Dengan Metode Kneading

Indra Makmur (STIFARM Padang)
Auzal Halim (STIFARM Padang)
Maria Dona Oktavia (STIFARM Padang)
Helvia Angraeni (Unknown)



Article Info

Publish Date
05 Mar 2018

Abstract

Preparation and characterization of inclusion complex of amlodipine besylat with β - cyclodextrin has been done. Preparation of the inclusion complex was carried kneading method. Formed inclusion complex was characterized by X-ray diffraction, FT - IR spectrophotometer, Scanning Electron Microscopy (SEM), and the dissolution test. Data from X-ray diffraction, FT - IR, SEM can be concluded that inclusion complexes with kneading method give the best results. The dissolution efficient  results showed that the inclusion complex of amlodipine besylat - β - cyclodextrin with a kneading method increased significantly when compared with the active ingredient and the mixture of physics.

Copyrights © 2018