Karakterisasi Kompleks Inklusi Simvastatin – Β-Siklodekstrin Metoda Co-Grinding dengan Variasi Waktu Penggilingan

Maria Dona Octavia (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Auzal Halim (Fakultas Farmasi Universitas Andalas Padang)
Monica Afrinda (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)

Jurnal Farmasi Higea
Vol 7, No 1 (2015)

Characterization of simvastatin - b-cyclodextrin inclusion complexes by co-grinding method had been studied. Solid state simvastatin - b-cyclodextrin inclusion complex prepared by co-grinding method in 1:1 mol ratio. Simvastatin, b-cyclodextrin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes were characterization by X-ray Diffraction (XRD), Fourier Transformation Infra red (FTIR), Differential Thermal Analysis (DTA), scanning electron microscope (SEM) and dissolution studies. X-Ray Diffraction results showed decreasing peak intensity diffractogram very sharp compared to pure simvastatin and differential thermal analysis (DTA) were showed the interaction between simvastatin and b-cyclodextrin. In vitro dissolution rate studies of simvastatin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes. Simvastatin - b-cyclodextrin inclusion complex showed increasing dissolution rate significant compared to simvastatin - b-cyclodextrin physical mixture and pure simvatatin. The results showed the formation of inclusion complex between simvastatin and b-cyclodextrin by co-grinding method.