Studi Sistem Dispersi Padat Ibuprofen – Manitol Dengan Metode Pelarutan

Rina Wahyuni (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Salman Umar (Fakultas Farmasi Universitas Andalas Padang)
Zulfareda Putri (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)

Jurnal Farmasi Higea
Vol 8, No 1 (2016)

Study of solid dispersions of ibuprofen-manitol by solvent method had been researched. Solid dispersions made in 4 ratio formula, F1; F2; F3 and F4 with ibuprofen-manitol ratio  3: 1, 2: 2, 1: 3, and 0.5: 3.5. Evaluation of solid dispersions of Ibuprofen - Manitol include x-ray diffraction (XRD), FT-IR spectroscopy, scanning electron microscopy (SEM), assay and dissolution test. Results of X-ray diffraction solid dispersion system showed a decrease in intensity of the degree of crystalline ibuprofen. SEM characterization results indicated ibuprofen morphological changes towards more amorphous.