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All Journal Jurnal Farmasi Higea
Zulfareda Putri
Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang
Medicine & Pharmacology

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Studi Sistem Dispersi Padat Ibuprofen – Manitol Dengan Metode Pelarutan Rina Wahyuni; Salman Umar; Zulfareda Putri
Jurnal Farmasi Higea Vol 8, No 1 (2016)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (817.298 KB) | DOI: 10.52689/higea.v8i1.140

Abstract

Study of solid dispersions of ibuprofen-manitol by solvent method had been researched. Solid dispersions made in 4 ratio formula, F1; F2; F3 and F4 with ibuprofen-manitol ratio  3: 1, 2: 2, 1: 3, and 0.5: 3.5. Evaluation of solid dispersions of Ibuprofen - Manitol include x-ray diffraction (XRD), FT-IR spectroscopy, scanning electron microscopy (SEM), assay and dissolution test. Results of X-ray diffraction solid dispersion system showed a decrease in intensity of the degree of crystalline ibuprofen. SEM characterization results indicated ibuprofen morphological changes towards more amorphous.
Co-Authors Rina Wahyuni Salman -