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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 12 Documents
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Search results for , issue "Vol 6, No 1 (2017): Edisi Maret 2017" : 12 Documents clear
Pengaruh Pemberian Sarang Telur Laba-Laba (Spider Silk Protein) Menemerus Bivittatus Secara Topikal Terhadap Penyembuhan Luka Insisi Pada Fase Inflamasi Tikus Putih Jantan (Rattus Norvegicus) Strain Wistar Muhammad Yusak Alfaris; Mas Mansyur
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 1 (2017): Edisi Maret 2017
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.908 KB) | DOI: 10.30742/jikw.v6i1.325

Abstract

The healing of wounds is a natural process of the human body but often medicine is used, for example the use of spider silk. The purpose of this research is to know the effect of the use of spider (Menemerus Bivittatus) silk protein used topically for the healing of incision wounds in the inflammatory phase. This research is a laboratory experiment. The subjects of this research are 18 wistar rats (Rattus Norvegicus strain) that are treated in two different ways. The first is control (K1) with the use of normal saline and the second is treatment (Pl) with the use of spider silk protein topically using wound dressing. The selection of samples is done randomly using the simple random sampling. The hypothesis testing uses the Chi Square testing with α = 0.05. The results of this research shows that the use of spider silk protein topically effects the process of incision wound healing (0,005) in the inflammatory phase (0,000) on Wistar rats.
Pengaruh Ekstrak Tamarindus indica Terhadap Kenaikan Berat Badan Pada Tikus Rattus norvegicus Yang Diberi Diet Obesitas Candra Rini Hasanah Putri; Titiek Sunaryati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 1 (2017): Edisi Maret 2017
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.649 KB) | DOI: 10.30742/jikw.v6i1.321

Abstract

Obesity is a health problem whose prevalence tends to increase in Indonesia. Obesity becomes a concern, because it is one of the parameters that often followed by impaired of glucose tolerance in the metabolic syndrome. In Indonesia, Tamarindus indica is believed as a body slimming substance so it has possibility to become an alternative therapy that is easily available and cheap for obesity. The purpose of this study was to determine the ability of Tamarindus indica in inhibiting obesity. This experiment used 28 male Wistar strains in 2-3 months age that were divided into groups: group 1 (negative control, normal diet without Tamarindus indica), group 2 (positive control, obese diet without Tamarindus indica), group 3 (obese diet + Tamarindus indica 2700mg/kg BW), and group 4 (obese diet + Tamarindus indica 3600mg/kg BW). Measurement were performed in the first day after acclimization before treatment (day 8), and repeated weekly afterwards, ie at day 15, 22, 29, 36, and 43. Anova and Tukey Simultaneous statistics test were performed to see the differences in wight gain per week compared with the first week of study, then compared between groups.  Furthermore, a virtual screening that called insilico bioinformatics analyzes was performed to test the binding activity between quercetin and rutin (compounds in Tamarindus indica) with fatty acid synthase, an enzym that plays a role in de novo synthesis of fatty acids. Tamarindus indica was shown to significantly inhibit weight gain in rats with obese diet food (P=0.000), but differences dose of Tamarindus indica did not appear to have significant effect to inhibit obesity (P=0.321). The ability of Tamarindus indica is due to the compounds quercetin and rutin, where these two ingredients estimated to have the ability to inhibit fatty acid synthase with high strength. 

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