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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 7 Documents

Search results for , issue "Vol 13, No 1 (2016)" : 7 Documents clear

METODE PEMANASAN DAN SONIKASI MENGHASILKAN NANOLIPOSOM DARI FOSFOLIPID LESITIN KEDELAI (SOY LECITHIN) Rini Dwiastuti; Sri Noegrohati; Enade Perdana Istyastono; Marchaban Marchaban
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Liposomes in topical drug delivery preparation is developed because having a good penetration through the skin. The lecithin which is often used in liposome formulations is soy lecithin. Heating and sonication methods can be done to reduce the size of the particles. This study aims to produce nanoliposom dosage formulations of soy lecithin phospholipids by using a combination of heating and sonication methods to generate liposomes with size 150nm . The methods of nanoliposomes preparation in this study using a combination of heating 60?C and sonication methods for about 30 minutes in the manufacturing process . The results showed that the preparation of nanoliposomes formulation from soy lecithin can be done by using a combination of heating 60?C and sonication methods for about 30 minutes.

PEMANFAATAN EKSTRAK TERSTANDARDISASI DAUN SOM JAWA (Talinum paniculatum (Jacq.) Gaertn) DALAM SEDIAAN KRIM ANTIBAKTERI Staphylococcus aureus Wahyuning Setyani; Hanny Setyowati; Dewi Ayuningtyas
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Infectious diseases have been the leading cause of morbidity and mortality because of the widespread antibacterial resistance due to existing drugs. Thus, the discovery and development of new antimicrobial agents, especially from natural resources is important to promote the human health.This research aimed to examine the antibacterial activity of som jawa (Talinum paniculatum (Jacq.) Gaertn.) standardized extract thus their application into cream. Extraction was done by remaceration method, then followed by phytochemical investigation to obtain the active ingredients inside extract. The result of this research showed that both som jawa standardized extract and their formula cream had antibacterial activity towards Staphylococcus aureus. This formula cream was potential as alternative herbal medicine for skin infection caused by Staphylococcus aureus.

KAJIAN FAKTOR DEMOGRAFI TERHADAP KEPUASAN PASIEN JAMINAN KESEHATAN NASIONAL PADA FASILITAS KESEHATAN TINGKAT PERTAMA Putu Dyana Christasani; Satibi Satibi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

The National Health Insurance (JKN), an Indonesian health care system, has been organized by BPJS Kesehatan using health care assurance mechanism. JKN system gave its service in collaboration with the existing health facilities throughout Indonesia. Primary health facilities named Puskesmas and Klinik Pratama, were playing role as the gate keeper of JKN system in order to provide basic health services optimally. The JKN participants satisfaction could be used as the indicator for measuring the success rate of the JKN system. The patient demographics was being one of several factor affecting the JKN participants satisfaction. This study aimed to examine the relationship between patient demographics and JKN participants satisfaction in Puskesmas and Klinik Pratama located in Sleman, Bantul and Yogyakarta city. This research performed the descriptive analytic using cross sectional survey design. The patientss demographics examined in this study were patients age, patients gender, patients education, patients employment, patients income, and membership status. The data taken quantitatively using questionnaires and equipped with qualitative data from interviewing the patients to obtain all the possible findings in the field. Sampling techniques for primary health facilities was performed by random sampling with total sample of 55 health facilities and purposive sampling with a total sample of 150 respondents. Data were analyzed using Chi-Square method to obtain the relationship between patient demographics and JKN participants satisfaction. The results showed that patients employment, patients income, and membership status were significantly related to the JKN participants satisfaction in Puskesmas and Klinik Pratama.

MOLECULAR DOCKING OF COMPOUNDS FROM Chaetomium Sp. AGAINST HUMAN ESTROGEN RECEPTOR ALPHA IN SEARCHING ANTI BREAST CANCER Maywan Hariono; Rollando Rollando
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

A study on molecular docking-based virtual screening has been conducted to select virtual hit of compounds, reported its existence in fungal endophytes of Chaetomium sp. as cytotoxic agent of breast cancer. The ligands were docked into Human Estrogen Receptor alpha (HERa) as the protein which regulates the breast cancer growth via estradiol-estrogen receptor binding intervention. The results showed that two compounds bearing xanthone and two compounds bearing benzonaphtyridinedione scaffolds were selected as virtual hit ligands for HERa leading to the conclusion that these compounds were good to be developed as anti breast cancer.

EFEK PEMBERIAN JUS BUAH PISANG AMBON (Musa paradisiaca var. sapientum (L.) Kunt.) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG TERBEBANI GLUKOSA Katherine Jessica Ariani; Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

This research is to know the effect of giving Musa paradisiaca var. sapientum (L.) Kunt. juice to the blood glucose levels and to know the most effective of giving Musa paradisiaca var. sapientum (L.) Kunt. dose to lower the blood glucose levels in rats with oral glucose tolerance. This research was experimental study with one way-complete-random design using 25 male rats were divided into five groups. The rats in group I (negative control) were given of CMC 1%, the group II rats were given 0.64mg/kgBW doses of Glibenclamide (positive control), and group III,IV and V were given 5, 10 and 20 ml/kgBW doses of Musa paradisiaca var. sapientum (L.) Kunt. juice. The hypoglycemic effect of Musa paradisiaca var. sapientum (L.) Kunt. juice was tested by following the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents were taken, at 0 minutes before OGTT, and also taken at minutes of 15, 20, 45, 60, 90, 120, 180, and 240 after OGTT, from the tested animal that had been gotten the pre-treatment of negative control, positive control and Musa paradisiaca var. sapientum (L.) Kunt. juice. The blood glucose levels was determined by using enzymatis GOD-PAP method. The AUC0-240 was statistically analyzed using one way ANOVA and Scheffe test with 95% convidence level. The result of this research showed that Musa paradisiaca var. sapientum (L.) Kunt. can lower on rats in burdened glucose. The effective dose of Musa paradisiaca var. sapientum (L.) Kunt. juice can lower glucose blood levels at 5ml/kgBW.

EVALUASI DAMPAK PENERAPAN AUTOMATED DISPENSING MACHINE TERHADAP DISPENSING ERROR DI FARMASI RAWAT JALAN INSTALASI FARMASI RUMAH SAKIT BETHESDA YOGYKARTA Purwoadi Sujatno; Rizaldy Taslim Pinzon; Andreasta Meliala
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Dispensing error is not uncommon in the medication proccess. Otomatisation of outpatient pharmacy services decrease the incidence of dispensing error, as well as improving the efficiency of picking, packing and labeling process. Since August 2014 an automated dispensing machine was installed in outpatient pharmascy Bethesda Hospital Yogyakarta, integrated with electronic prescribing and hospital information system. The objective of the study was to evaluate the impact of automated dispensing machine on the dispensing error at outpatient pharmacy Services using before and after study method. The procentage of drugs deliver by automated dispensing machine at the third and sixth month of implementation was 46% and 59%. Failure mode and effeect analysis of dispensing process done before the implementation, and the integration with electronic prescription and hospital information system, as well as the development of smart pack is the key of successed. The average of medications picked after the implementation of automated dispensing machine was (37,915.33 3,160.12), higher than before implementation (36,812.67 2,890.81), but not significant. The average of dispensing error after implementation (15,67 6,28) was reduced significantly (p0,05) than before (50.33 34.47). The most frequent type of dispensing error were wrong quantity dispensed, wrong drug dispensed and wrong strength dispensed. The implementation of automated dispensing machine significantly reduce the incidence of dispensing error. Further investigaation needed to know the incidence of dispesning error cause by the machine and manual and factors that influenced.

UJI AKTIVITAS ANALGESIK ASAM 2-(3-(KLOROMETIL)BENZOILOKSI)BENZOAT DAN ASAM 2-(4-(KLOROMETIL)BENZOILOKSI)BENZOAT PADA TIKUS WISTAR JANTAN DENGAN METODE PLANTAR TEST Wahyu Dewi Tamayanti; Ratna Megawati Widharna; Caroline Caroline; Bambang Soekarjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

The new compounds of salicylic acid derivatives, 2- (3- (chloromethyl) benzoyloxy) benzoic acid and 2- (4- (chloromethyl) benzoyloxy) benzoic acid were synthesized to generate better analgesic activity and lesser stomach irritation of salicylic acid. The 2- (4- (chloromethyl) benzoyloxy) benzoic acid and 2- (3- (chloromethyl) benzoiloksi) benzoic acid were synthesized by Schotten-Baumann acylation process. In this study, analgesic activity was tested by plantar test method. The compounds were administered to the tested animals at 12.5; 25; 50; 100; and 200 mg / kg BW of doses. Analgesic activity was determined by the response time of rat to pain induced by infra red. The percentage of pain hindrance was calculated from the mean of response time to pain. Pain hindrance percentage were shown as: 74.28%; 105.58%; 110.58%; 115.29%; and 175.87% after administration of 2- (4- (chloromethyl) benzoyloxy) benzoic acid at doses of 12.5; 25; 50; 100; and 200 mg / kg. The pain hindrance percentage after administration of 2- (3- (chloromethyl) benzoyloxy) benzoaic acid, were 85.30%; 92.48%; 124.96%; 180.36%; and 208.01% respective to the doses of 12.5; 25; 50; 100; and 200 mg / kg. Five doses of acetyl salicylic acid ranged from 12.5 mg / kg to 200 mg / kg showed pain hindrance percentage as: 26%; 34.34%; 45.68%; 60.38%; and 114.12%. This study indicated that 2- (3- (chloromethyl) benzoyloxy) benzoic acid and 2- (4- (chloromethyl) benzoyloxy) benzoic acid generated higher analgesic activity than acetyl salicylic acid.

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Florentinus Dika Octa Riswanto

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editorial.jpsc@usd.ac.id

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editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA