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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat

Rini Dwiastuti

Faculty Of Pharmacy, Universitas Sanata Dharma

Author-ID : 2385635

Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Medicine & Pharmacology Public Health Social Sciences Other

Published : 11 Documents Claim Missing Document

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LIPID AND SILVER NANOPARTICLES GELS FORMULATION OF TEMPEH EXTRACT Felicia Satya Christania; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Tempeh extract is used in this study as an active ingredient in lipid nanoparticles and reductant in silver nanoparticles because tempeh is an authentic Indonesian food ingredient and is known to have the main content of isoflavones. Gel preparations were chosen to increase the acceptability and stability of lipid and silver nanoparticles. This research is aimed to formulate lipid nanoparticle gel formulations with tempeh extract as active substances and silver nanoparticle gel formulations with tempeh extract as bioreduction. Lipid nanoparticles were made from soy lecithin phospholipids by heating at 600C and sonication method for 30 minutes then the tempeh extract was added just before sonication. Silver nanoparticles were made by adding tempeh extract to the AgNO3 solution at 900C for 30 minutes. The average particle size of tempeh extract lipid nanoparticles was 130.03 nm and silver nanoparticle was 94.76 nm. The average viscosity of tempeh extract lipid nanoparticles gel was 4.02 d.Pa.s and silver nanoparticles was 4.22 d.Pa.s. The average spreadability of tempeh extract lipid nanoparticles gel was 4.37 cm and silver nanoparticles was 4.05 cm. The average pH value of tempeh extract lipid nanoparticles was 7.70 and silver nanoparticles was 7.33.

METODE PEMANASAN DAN SONIKASI MENGHASILKAN NANOLIPOSOM DARI FOSFOLIPID LESITIN KEDELAI (SOY LECITHIN) Rini Dwiastuti; Sri Noegrohati; Enade Perdana Istyastono; Marchaban Marchaban
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 1 (2016)
Publisher : Sanata Dharma University

Liposomes in topical drug delivery preparation is developed because having a good penetration through the skin. The lecithin which is often used in liposome formulations is soy lecithin. Heating and sonication methods can be done to reduce the size of the particles. This study aims to produce nanoliposom dosage formulations of soy lecithin phospholipids by using a combination of heating and sonication methods to generate liposomes with size 150nm . The methods of nanoliposomes preparation in this study using a combination of heating 60?C and sonication methods for about 30 minutes in the manufacturing process . The results showed that the preparation of nanoliposomes formulation from soy lecithin can be done by using a combination of heating 60?C and sonication methods for about 30 minutes.

THE EFFECT OF TEMPEH EXTRACT GEL ON WOUND HEALING IN DIABETES RAT: OVERVIEW OF TISSUE COLLAGEN, WOUND CLOSURE, EPITHELIALIZATION AND CAPILLARIZATION Ignasius Adi Kurniawan; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The development of wound healing preparations in diabetes conditions needs to be done because the wound healing process in the respective conditions requires longer time. The aim of this study is to measure the effect of tempeh extract gel containing genistein on wound healing in diabetes rats by observing the response parameters of collagen expression, wound closure speed, epithelialization, and capillarization of wound tissue. The results of testing wound closure using a base gel treatment, tempeh extract gel 2.5%, 5%, 7.5% and without treatment indicated that the treated groups of tempeh extract gel 5% and 7.5% have significant effect on diabetes wound healing in the tested animals. This indication is strengthened by the results of the non-treatment groups statistical test with the 5% and 7.5% tempeh extract gel treatment which showed significant difference in influencing the wound closure response, epithelialization and collagen formation in tissue. The results of the statistical in group without treatment with the base treatment group without extract gel and tempeh extract gel 2.5% showed no significant difference in influencing the wound closure response, epithelialization and collagen formation. Statistical test results on capillarization responses indicated that the results were not significantly different from all treatment groups.

PENDAMPINGAN KEPADA SISWA SEKOLAH MENENGAH DI YOGYAKARTA DALAM PENERAPAN 5M SEBAGAI PERSIAPAN PEMBELAJARAN LURING Dina Christin Ayuning Putri; Sri Hartati Yuliani; Rini Dwiastuti
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 1 (2022): April 2022
Publisher : Universitas Sanata Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/aa.v5i1.3830

The COVID-19 pandemic that has hit the whole world has affected various aspects of life, including education. Education during the pandemic is carried out online which has the potential to cause learning loss for students. Face-to-face learning is needed for students by considering all the risks. Preparation for offline learning is done by equipping students in implementing health protocols. This activity aims to equip students to be ready to carry out face-to-face learning by applying the ‘5M’ programs. Activities are carried out in the form of mentoring and discussion. The effectiveness of the activity was observed by comparing the pretest and posttest scores. The results show that the students' posttest scores are greater than the pretest scores, so it can be concluded that this activity is useful in adding students' knowledge of the ‘5M’ program as an effort to prevent COVID-19 transmission during face-to-face learning.

Kajian Potensi Inkompatibilitas dan Instabilitas: Studi Kasus Sediaan Racikan Mengandung Amitriptilin, Trifluoperazine Dihidroklorida dan Alprazolam Desi Amroni Kasanah; Dina Christin Ayuning Putri; Sri Hartati Yuliani; Rini Dwiastuti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 4, No 2 (2019)
Publisher : Universitas Sebelas Maret

Meracik obat merupakan salah satu tugas tenaga kefarmasian. Peracikan obat merupakan salah satu risiko penyebab medication error. Resep racikan yang mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam adalah jenis peresepan dengan tingkat risiko tinggi, sedangkan informasi tentang sediaan racikan kombinasi obat tersebut masih sangat terbatas. Studi ini bertujuan untuk memberikan informasi mengenai risiko peracikan, potensi instabilitas, dan potensi inkompatibilitas pada resep racikan sediaan kapsul yang mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam di sebuah rumah sakit di Semarang. Analisis risiko resep dilakukan dengan memperhatikan aspek risiko teknis dan risiko klinis, sedangkan pengkajian terhadap potensi instabilitas dan inkompatibilitas dilakukan secara sistematis menggunakan beberapa literatur sengan kriteria yang telah ditetapkan. Hasil analisis risiko menunjukkan bahwa resep racikan mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam memiliki risiko peracikan yang sangat tinggi. Berdasarkan penelusuran literatur sistematis, ditemukan adanya potensi ketidakstabilan dan inkompatibilitas yang mungkin terjadi yaitu penarikan lembab dan reaksi hidrolisis. Berbagai upaya teknis dapat dilakukan oleh tenaga kefarmasian untuk meningkatkan kualitas obat dan menjamin keamanannya yaitu menggunakan cangkang kapsul HPMC, menyimpan sediaan dalam wadah tertutup kedap, terhindar dari cahaya langsung pada suhu ruang dan menambahkan silika gel. Meskipun demikian, potensi instabilitas dan inkompatibilitas yang ditemukan dalam studi ini masih berdasar pada kajian pustaka, sehingga perlu dilakukan penelitian eksperimental untuk mengetahui profil stabilitas dan kompatibilitas sediaan racikan tersebut.

Molecular Dynamics Simulations and Empirical Observations on Soy Lecithin Liposome Preparation Rini Dwiastuti; Muhammad Radifar; Marchaban Marchaban; Sri Noegrohati; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

Soy lecithin is a phospholipid often used in liposome formulations. Determination of water and phospholipid composition is one of the problems in the liposome formulation. This study is using molecular dynamics simulation and empirical observation in producing liposome preparations. Phospholipids 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) were objected in molecular dynamics simulations using Coarse Grained Molecular Dynamics (CGMD) approaches. The result showed that the molecular dynamic simulations could be employed to predict the liposome size. The molecular dynamic simulations resulted in liposome size of 71.22 ± 2.54 nm, which was located within the range of the liposome size resulted from the empirical observations (95.99 ± 43.02 nm). Moreover, similar liposome forms were observed on both results of molecular dynamics simulations and empirical approaches.

Analytical Method Validation and Determination of Free Drug Content of 4-n-Butylresorcinol in Complex Lipid Nanoparticles Using RP-HPLC Method Rini Dwiastuti; Marchaban Marchaban; Enade Perdana Istyastono; Florentinus Dika Octa Riswanto
Indonesian Journal of Chemistry Vol 18, No 3 (2018)
Publisher : Universitas Gadjah Mada

Lipid nanoparticles, one of nanoparticle technology results has been developed both as a drug delivery system and as a research object. Complex lipid nanoparticle, in the drug delivery system development, has an advantage due to its less toxicity. It is important to develop a validated analytical method to determine the drug content in the system of nanoparticle lipid. This research aimed to develop a valid RP-HPLC method to determine free drug content of 4-n-butylresorcinol in the liposome matrix followed by the determination of the encapsulation efficiency (EE%). A system of the RP-HPLC method has been developed using a column of C18 and methanol-redistilled water-glacial acetic acid 79:20:1 (v/v) as the mobile phase with pH maintained at 2.1–2.6. This method was validated in the parameters of selectivity, sensitivity, linearity, accuracy, and precision. During 30 days of storage, the complex lipid nanoparticle system showed the increase in the EE% value during storage time.

Multiple Response Optimization of a HPLC Method for Analyzing Resorcinol and 4-n-Butyl Resorcinol in Lipid Nanoparticles Rini Dwiastuti; Dina Christin Ayuning Putri; Maywan Hariono; Florentinus Dika Octa Riswanto
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.58537

Resorcinol and 4-n-butyl resorcinol have been used to improve skin health. However, these two compounds were unstable due to the oxidation process. Lipid nanoparticle formulation strategies were reported as the solution to overcome the stability problem for both resorcinol and 4-n-butyl resorcinol. Nevertheless, it is important to determine the content of resorcinol and 4-n-butyl resorcinol in lipid nanoparticle formulation. Aiming to develop the analytical method for resorcinol and 4-n-butyl resorcinol determination, a response surface methodology (RSM) was applied in the HPLC optimization stage. An optimized HPLC condition was obtained by generating a Box-Behnken design followed by multiple response analysis. It was obtained that optimized HPLC conditions due to the predictive multiple response optimization were methanol percentage of 50.0%, acetonitrile percentage of 18.1%, and flow rate of 0.6 mL min–1. This optimized condition was successfully applied and met the requirements of the system suitability test. Quantitative estimation was performed and resulted that the resorcinol and 4-n-butyl resorcinol content in lipid nanoparticles were 70.37 ± 0.47 and 95.07 ± 0.80 µg mL–1, respectively.

Sunscreen Cream Formulation of Noni Leaf Extract (Morinda citrifolia L.) with Emulsifier Combination of Tween 80 and Lecithin Bianca Levie Tania; Rini Dwiastuti; Agatha Budi Susiana Lestari; Dewi Setyaningsih
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.262-271

Background: Noni leaf (Morinda citrifolia L.) extract is a natural product that can be used as a sunscreen. The extract contains flavonoids which function act as an antioxidant. In this work, sunscreen cream formulated with noni leaf extract was prepared using a combination of tween 80 and lecithin. Objective: The purpose of this study is to evaluate how the combination of tween 80 and lecithin affects the physical qualities of the cream, such as organoleptic, homogeneity, emulsion type, spreadability, adhesion, pH, and stability over 28 days of storage at room temperature, and to find the best formula. Methods: This study used 10% of noni leaf extract in the cream formulation. The Simplex Lattice Design (SLD) method was used to determine the effect of different concentrations of the two emulsifiers on the cream's spreadability, adhesion, and pH. Furthermore, the SLD was used to find the best formula. Results: The results showed that different concentrations of the emulsifier, which are the tween 80 and lecithin combination, affected the physical properties and storage stability of cream preparations. The interaction of tween 80 and lecithin is having a significant impact on the cream's adhesion and spreadability; however, the effect of the interaction on the pH value was not significant. Conclusion: The formula containing 2.5 % tween 80 and 2.5 percent lecithin was found to be the most effective in fulfilling the cream physical properties while remaining stable during storage.

Optimization of Nanosilver Synthesis Process with Bioreductor of Binahong Leaf Extract (Anredera cordifolia (Ten.) Steenis) Rini Dwiastuti; Elsa Irnandari; Michael Raharja Gani; Sri Hartati Yuliani; Christofori Maria Ratna Rini Nastiti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Nanosilver is a type of metallic silver nanoparticles and has a particle size of 1-100 nm. The method used in the synthesis of nanosilver is a chemical reduction method with silver metal precursor AgNO3 and a bioreductant of binahong leaf extract containing flavonoid compounds. This study aims to obtain the duration, temperature and optimum point in the synthesis of nanosilver with the bioreductant of binahong leaf extract using the sonication method. This type of research is purely experimental with a 2x2 factorial design. The nanosilver characterization was conducted by determining the optimum wavelength and the transmittance value of the nanosilver formed. The effect of temperature and duration of sonication on the wavelength and % transmittance of the synthesized nanosilver in this study were analyzed by ANOVA statistical test using the Minitab 19 application with a 95% confidence level. In this study, the temperature and duration of sonication as well as their interactions have an effect on the transmittance response. The statistical results of the model have a significant effect on the % transmittance response only with p-value 0.05. The optimum point was found in the synthesis of nanosilver with the bioreductant of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) using a 2x2 factorial design, namely at a sonication temperature of 80°C for 10 minutes, a sonication temperature of 70oC for 15 minutes and a sonication temperature of 80oC for 15 minutes.

Co-Authors Agatha Budi Susiana Lestari Akhmad Kharis Nugroho Bianca Levie Tania Christofori Maria Ratna Rini Nastiti Desi Amroni Kasanah Dewi Setyaningsih Dina Christin Ayuning Putri Elsa Irnandari Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Felicia Satya Christania Florentinus Dika Octa Riswanto Ignasius Adi Kurniawan Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban Maywan Hariono Michael Raharja Gani Muhammad Radifar Sri Hartati Yuliani Sri Noegrohati Sri Noegrohati

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