cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhammad Sulaiman Zubair
Contact Email
sulaiman_zubair80@yahoo.co.id
Phone
+6285242083654
Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com
Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako
Location
Kota palu,
Sulawesi tengah
INDONESIA
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Published by Universitas Tadulako
ISSN : 24427284     EISSN : 24428744     DOI : https://doi.org/10.22487/j24428744
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 12 Documents
 1   2 
Search results for , issue "Vol. 10 No. 2 (2024): (October 2024)" : 12 Documents clear
Larvicidal Activity of Bay Leaf (Syzygium polyanthum) Ethanolic Extract in Addition of PEG Diluent on Aedes aegypti Larvae : Aktivitas Larvasida Ekstrak Ethanol Daun Salam (Syzygium polyanthum) Dengan Penambahan Pengencer PEG Terhadap Larva Nyamuk Aedes aegypti Dewi, Listiana Masyita; Salsabila, Tasya Viona; Bestari, Rochmadina Suci; Wahyuni, Sri
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16335

Abstract

Background: Dengue Fever (DF) is a viral infection disease transmitted by Aedes aegypti. It is one of Indonesian endemic diseases that reported to occur throughout the year. To break the transmission chain of DF, the use of larvicides is preferred, especially using natural ingredients, such as bay leaves (Syzygium polyanthum). Polyethylene glycol (PEG) as a dispersant may prevent the clumping of material test so that it can be distributed evenly in water which is the medium of growth for larvae. Objectives: To determine the effectiveness of ethanolic extract of bay leaves (EEBL) in addition of PEG diluent on the mortality of Aedes aegypti larvae. Material and Method: Bay leaves as the main material were extracted using 96% of ethanol, and were applied in two variation concentration, 0.75% and 1%, while the diluent added was PEG. The samples used in this study were Aedes aegypti larvae at stages III-IV, with a total of 25 individuals for each treatment group. Evaluation was performed every 6 hours, for 24 hours, then the results were recorded and analyzed using the Kruskall Wallis test and the Mann Whitney test. Result: In both of variation concentration used, at 24 hours of observation it was obtained the mortality of Aedes aegypti larvae was 100%. The p-value obtained for the Kruskall Wallis test was <0.05. From Mann Whitney test, when each of treatment group was compared to the positive control, abate®, the p-value obtained is >0.05, while when they were compared to the negative control, PEG, the p-value obtained is <0.05. Conclusion: 96% ethanolic extract of bay leaves in addition of PEG diluent is effective as Aedes aegypti larvicides. It is also known that EEBL at concentration of 0.75% and 1% in addition of PEG are as effective as abate® as Aedes aegypti larvicides.
Determination of Phenolic and Flavonoid Total Levels and Antioxidant Activity of Ethanol, Ethyl Acetate, and n-Hexane Extracts of Citrus reticulata Blanco Fruit Peel by DPPH and ABTS Methods: Penetapan Kadar Total Fenol dan Flavonoid serta Aktivitas Antioksidan Ekstrak Etanol, Etil Asetat, dan n-Heksan Kulit Buah Citrus reticulata Blanco dengan Metode DPPH dan ABTS Fadhlillah, Faizah Min; Miranti, Mila; Wibowo, Diki Prayugo; Purkon, Dicki Bakhtiar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16399

Abstract

Background: The peel of the fruit Citrus reticulata Blanco has long been used in traditional medicine due to its various properties. Traditional medicine from certain parts of medicinal plants is related to the content of bioactive compounds from the fruit's peel, such as phenolic compounds and flavonoids that can help protect the body from damage caused by free radicals. Objectives: This study aimed to evaluate the total levels of phenolics and flavonoids as well as antioxidants from ethanol, ethyl acetate, and n-hexane extracts from the skin of Citrus reticulata Blanco using DPPH (2,2-diphenyl-1-picrylhydrazil) and ABTS (2,2'-azinobis-(3-ethylbenzothiazolin-6-sulphonate))) methods. Material and Methods: The extraction process was carried out using the maceration ion method with ethanol, ethyl acetate, and n-hexane solvents at room temperature for 24 hours. Total phenolic and flavonoid levels in the extract were determined using UV-Vis spectrophotometry, and antioxidant activity testing was determined based on the extract's ability to neutralize free radicals from DPPH and ABTS. Results: The results showed that the ethanol extract of Citrus reticulata Blanco fruit peel had higher total phenolic and flavonoid levels compared to ethyl acetate and n-hexane extracts. The total phenolic levels in ethanol, ethyl acetate, and n-hexane extracts were 142.02, 74.60, and 57.17 mg GAE/g, respectively. The total flavonoid levels in ethanol, ethyl acetate, and n-hexane extracts were 45.96, 40.22, and 38.54 mg QE/g, respectively. In addition, ethanol extract has also shown the strongest antioxidant activity based on the results of testing with DPPH and ABTS methods. The inhibitory concentration (IC50) of ethanol extract against DPPH and ABTS methods was 23,490 μg/mL and 31,971 μg/mL, respectively, with strong category. Conclusions: This study shows that the skin of Citrus reticulata Blanco fruit contains phenolic compounds and flavonoids that have the potential as natural antioxidants, with ethanol extract being the most promising related to total phenolic and flavonoid levels and antioxidant activity. This information can be used as a basis for developing pharmaceutical dosage products and health supplements that can potentially improve antioxidant/health status in the body.
Metabolite Fingerprints and Chemometrics-Based Approach for Discrimination of Miana (Coleus scutellarioides) Variety: Authentication of Traditional Medicine Raw Materials Syahruni, Reny; Umar, Abdul Halim; Lido, Fenisia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16534

Abstract

Background: Miana (Coleus scutellarioides) is a plant from the Lamiaceae family consisting of several varieties that are traditionally used as medicinal materials, especially its leaves. Objectives: The study aims to classify/discriminate miana varieties based on FT-IR spectroscopic profiles and chemometric analysis (PCA, HCA, and PLS). Material and Methods: There are four samples used in this study, namely purple miana, green miana, batik miana, and combination miana (combination colour). The powders of the four miana samples were analyzed using FT-IR spectroscopy, then analyzed by chemometric techniques using PCA, HCA, and PLS to see the clustering patterns and functional group markers of the samples. Results: Based on chemometric analysis of FT-IR data, the four species of miana leaves showed grouping based on their varieties, respectively. The total PC value was 99.5% (PC-1 97.7% and PC-2 1.8%). HCA analysis at a distance of 2.5 resulted in 4 groups: a (DMB, DMK, and DMU), b (DMU and DMK), c (DMU and DMK), and d (DMH). PLS analysis using VIP scores showed C–H and C=O groups with values > 1. Conclusions: The combination of FT-IR and chemometrics can be applied to discriminate miana samples in quality control and authentication of traditional medicine raw materials. Analysis with LC-MS/MS and NMR instruments is needed for further analysis and support compounds that have the potential to distinguish the four miana varieties.
Formulation of Micellar Based Water from Piper crocatum Leaves Extract Using Various Concentrations of Poloxamer 188: Formulasi Micellar Berbasis Air Ekstrak Daun Sirih Merah (Piper crocatum) dengan Variasi Konsentrasi Poloxamer 188 Pratiwi, Hani; Okzelia, Sari Defi; Afiah, Mawar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16628

Abstract

Background: Micellar based water (micellar water) is a preparation used to clean the face or makeup with water-based ingredients. Micellar water has moisturizing additives accompanied by antioxidants. Piper crocatum leaves is one of the plants that contain flavonoid compounds so it has the potential as an antioxidant. Micelles are the main component in micellar water preparations derived from amphiphilic block copolymer-type surfactants such as poloxamer. Objectives: The purpose of this study was to formulate, evaluate, and observe the antioxidant activity of the most optimum formulation of micellar based water preparations of Piper crocatum leaves extract with variations in poloxamer 188 concentrations. Material and Methods: The stages of this research were material preparation, extract characteristics evaluation, production of micellar preparations at poloxamer 188 concentrations of 1% (F1); 1.5% (F2); and 2% (F3); preparation characteristics evaluation, stability, particle size, antioxidant activity assay for the optimum formula, and irritation test. Results: The results of the evaluation showed that the pH of the preparation ranged from 4.54 - 4.76; viscosity values ranged from 16.40 - 24.26 cP; particle size ranged from 170.6 – 349.9 nm; and the entire formula did not irritate the skin. Conclusions: Based on the results of this study, it was found that the most optimal concentration of poloxamer 188 was 2% (F3) with IC50 value of 119.63 ppm which categorized as a moderate antioxidant activity.
Factors Affecting Potentially Inappropriate Medications (PIMs) Based on STOPP/START Criteria in Geriatric Patients at RSUD Dr. Soedomo Trenggalek: Faktor-Faktor yang Mempengaruhi Potentially Inappropriate Medications (PIMs) Berdasarkan Kriteria STOPP/START pada Pasien Geriatri di RSUD Dr. Soedomo Trenggalek Widyaningrum, Esti Ambar; Fitriani, Marina; Irawati, Reny Nur Satya; Fajriyah, Shofiatul; Kurniawati, Evi; Lestari, Tri Puji
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16641

Abstract

Background: Geriatric patients often have multiple comorbidities and decreased physiological function, leading to polypharmacy and potential exposure to inappropriate medications (PIMs). Objectives: This study investigates geriatric inpatients' characteristic profiles, evaluates PIMs using STOPP/START criteria, and explores factors influencing PIM incidence. Method: This study employed a retrospective observational analytical approach. The sampling technique was purposive sampling. The sample involved in this study was 312 patients. Results: The geriatric patients involved in this study had the following characteristics: 62% male and 38% female; 69% youngest-old (65-74 years), 30% middle-old (75-90 years), and 1% oldest-old (>90 years); 87% with BPJS service type and 13% with general service type; main diagnosis groups of the patients were gastrointestinal of 9%, cardiovascular of 31%, respiratory of 3%, neurological of 1%, infection of 11%, endocrine of 13%, genitourinary of 15%, immune an malignant of 1%, blood of 11%, musculoskeletal of 2%, eyes of 2% and skin of 1%; 13% patients had one disease, 43% had two diseases, 25% had three diseases, and 19% had ≥ four diseases;29% had 15 drugs, 50% had 6-10 drugs, 17% had 11-15 drugs, 3% had 20 drugs, and 1% had ≥ 20 drugs. There were 72 PIMs based on STOPP/START criteria. The results of the analysis using the C contingency coefficient test showed the following factors, such as gender (p-value of 0.894), age (p-value of 0.470), type of service (p-value of 0.166), main diagnosis (p-value of 0.042), number of illness (p-value of 0.106), and number of drugs (p-value of 0.182). Conclusion: There is a correlation between the main diagnosis factor and PIMs with a p-value of 0.042 (p-value < 0.05).
Synergistic Effect Antibacterial Activity of The Combination of Andaliman (Zanthoxylum acanthopodium DC) Fruit Essential Oil and Erythromycin against Streptococcus mutans and Streptococcus pyogenes : Efek Sinergisme Aktivitas Antibakteri Kombinasi Minyak Atsiri Buah Andaliman (Zanthoxylum acanthopodium DC) dan Eritromisin terhadap Streptococcus mutans dan Streptococcus pyogenes Situmorang, Vania Clarissha; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra; Septama, Abdi Wira; Muti, Annisa Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16977

Abstract

Background: The concept of synergism is one of the approaches taken to combat the problems related to antibiotic resistance. Objectives: The goal of this study was to determine the synergistic effect of the antibacterial activity of a combination of essential oil of Zanthoxylum acanthopodium DC fruit and erythromycin against Streptococcus mutans and Streptococcus pyogenes. Methods: The broth microdilution assay was used to determine the Minimum Inhibitory Concentration (MIC) of Z. acanthpodium DC fruit essential oil and erythromycin. The synergistic effects were assessed using the checkerboard method. Results: MIC value of Z. acanthopodium DC fruit essential oil against both bacteria was 2500 mg/mL. The combination of Z. acanthopodium DC fruit essential oil and erythromycin had a synergistic effect against S. mutans and S. pyogenes with fractional inhibitory concentration index (FICI) values of 0.375 and 0.0872, respectively. Conclusions: These results suggest that a combination of herbal plants and conventional antibiotics could be used as an alternative therapy for bacterial infections.
Consumer Behavior Analysis as a Form of Pre-market Survey for the Black Pule (Alstonia spectabilis) Antimalarial Tablet Prototype: Analisis Perilaku Konsumen Sebagai Bentuk Survei Pre-market Tablet Prototipe Antimalaria Pule Hitam (Alstonia spectabilis) Taek, Maximus Markus; Ma'arif, Burhan; Maulina, Novia; Muslikh, Faisal Akhmal; Lalong, Paulus Risan Funan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16986

Abstract

Malaria is a disease caused by the protozoan parasite Plasmodium with a high incidence of spread that is still found in remote tropical places, especially areas around gardens, swamps, forests, and mines such as eastern Indonesia. The commonly used antimalarial drug chloroquine has experienced resistance, encouraging researchers to look for effective alternative treatments. Formulation development of Standardized Herbal Medicine (OHT) from black pule was carried out as a potential new alternative treatment as an antimalarial. Objectives: The purpose of this study was to determine the level of liking and quality assessment or characteristics of the prototype of antimalarial OHT tablets. Methods: The method used in this research is descriptive quantitative which aims to describe 57 panelists' perspective on the product and to analyze product marketing. In this research method includes hedonic test and hedonic quality test which is a series of organoleptic tests and consumer acceptance tests by tasting and observing the product followed by filling out a form according to what is felt and observed. Results: The results obtained from this research, namely the preference test of the overall characteristics of the prototype of antimalarial black pule tablets (Alstonia spectabilis) showed a good sensory impression and characteristics. The positive results obtained from all aspects have illustrated that the panelists have considerable interest in the prototype sample and assess that the prototype tablets are suitable for dissemination to the public. Conclusions: Based on the research, it can be concluded that the prototype of black pule (Alstonia spectabilis) tablets tested through hedonic and hedonic quality tests produced overall good results, characterized by the tendency of panelists to choose "Like" in the hedonic test of sensory impressions and positive values in the hedonic quality test.
Relationship between Knowledge and adherence to Use of TB Drugs in adults in Idaman Banjarbaru Hospital: Hubungan Pengetahuan terhadap Kepatuhan Minum Obat TBC Dewasa di RSD Idaman Banjarbaru Wati, Helmina; Kurniawan, Guntur; Abdurrahman, Faizah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17014

Abstract

Background: Tuberculosis (TB) is the disease that causes the highest mortality worldwide. One of the causes is the bacteria Mycobacterium tuberculosis. Knowledge and adherence are very important in TB treatment to achieve therapeutic success. Objectives: This study aims to see the relationship between the level of knowledge and adherence to taking medication for adult TB patients at Idaman Banjarbaru Hospital. Methods: This type of research is descriptive research with a cross-sectional research design, prospectively taken in March–June 2023. The total sampling technique was employed to select 42 patients. The data were collected via a validated online questionnaire and subsequently analysed using the Fisher Exact SPSS test with a 95% confidence level. Results: The results showed that patients had a good level of knowledge of as many as 32 people (76.2%) and had less knowledge of as many as 10 people (23.8%). The value of patient compliance in taking medication was 29 people (69%), and disobedient as many as 13 people (31%). Conclusion: The statistical analysis results indicated a statistically significant relationship between knowledge and compliance with medication in TB patients at Idaman Banjarbaru Hospital (p < 0.05). This implies that an individual's willingness to comply with medication regimens is significantly influenced by their knowledge about the prescribed treatment.
Toxicity Effect Test of Matoa (Pometia pinnata) Plant Fractions as Raw Materials for Anticancer Drugs: Uji Efek Toksisitas Fraksi Tanaman Matoa (Pometia pinnata) Sebagai Bahan Baku Obat Antikanker Hasan, Hamsidar; Taupik, Muhammad; Andi Suryadi, A. Mu’thi; Ihsan, Muh.
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17016

Abstract

Background:The prevalence of cancer in Indonesia increases every year. Medical treatments such as chemotherapy, surgery, and radiation require significant costs with considerable side effects. Therefore, there is a need for chemopreventive agents from natural sources such as plants. One plant with potential as a chemopreventive agent is the matoa tree (Pometia pinnata), which is empirically used to treat suppurating wounds.Objectives: This research aims to test the toxicity of leaf and stem bark fractions of matoa using shrimp larvae Artemia salina Leach. Methods: The parameter for this study is the LC50 value. The extraction method involves successive maceration using solvents based on increasing polarity, starting with n-hexane, chloroform, ethyl acetate, and methanol. Phytochemical screening is conducted using colour tests, and toxicity is assessed through the brine shrimp lethality test. The research indicates that all fractions of matoa leaves and stem bark are toxic with respective LC50 values for leaf fractions: n-hexane (394.8 µg/mL), chloroform (244.3 µg/mL), ethyl acetate (180.6 µg/mL), and methanol (303.2 µg/mL). Stem bark fractions exhibit LC50 values in the order of n-hexane (203.9 µg/mL), chloroform (244.3 µg/mL), ethyl acetate (144.8 µg/mL), and methanol (58.3 µg/mL). Conclusions: All fractions fall into the toxic category and have the potential as raw materials for anti-cancer drugs.
Effect of Levonorgestrel Implant on Lactation and Infant Growth: A Review: Review : Pengaruh Implan Levonorgestrel pada Laktasi dan Pertumbuhan Bayi Febrianti, Yosi; Hanifah, Suci; Febrian, M. Pandoman; Annisa, Lily; Azza, Lintang Prava; Mafruhah, Okti Ratna; Medisa, Dian; Sari, Chynthia Pradiftha
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17045

Abstract

Background: Family Planning is a way to regulate the number of children born and the spacing of pregnancies through information, education, and the use of contraceptives. Postpartum contraception is important to obtain an optimal interpregnancy interval. Postpartum contraception should be initiated early; one of which is Long-Acting Reversible Contraception (LARC). Levonorgestrel can be used to prevent pregnancy because it interferes with ovulation, implantation, and fertilization. Objectives: This study aimed to assess the efficacy and effects of using levonorgestrel implants on breastfeeding and infant growth. Methods: Primary data were in the form of research papers obtained from PubMed®, and Google Scholar® published from the period 2010-2018. The keywords for the searches included: “levonorgestrel”, “levonorgestrel (LNG)-releasing implant”, “levonorgestrel on lactogenesis”, “levonorgestrel on infant growth”, and “levonorgestrel on breastfeeding”, which were used alone or in combination. Results: The 20 selected articles were reviewed based on five identified phrases. Levonorgestrel subdermal implants were shown to be a good choice for women who wanted effective contraception. When used by breastfeeding mothers, levonorgestrel subdermal implants affected neither infant growth (0-1 year of age) nor lactation duration. Conclusions: Levonorgestrel subdermal implants can be effective long-term contraception. These implants are safe for breastfeeding mothers and do not affect infant growth.

Page 1 of 2 | Total Record : 12

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol. 11 No. 2 (2025): October 2025 Vol. 11 No. 1 (2025): (March 2025) Vol. 10 No. 2 (2024): (October 2024) Vol. 10 No. 1 (2024): (March 2024) Vol. 9 No. 2 (2023): (October 2023) Vol. 9 No. 1 (2023): (March 2023) Vol. 8 No. 2 (2022): (October 2022) Vol. 8 No. 1 (2022): (March 2022) Vol. 7 No. 3 (2021): (December 2021 Vol. 7 No. 2 (2021): (October 2021) Vol. 7 No. 1 (2021): (March 2021) Vol. 6 No. 2 (2020): (October 2020) Vol. 6 No. 1 (2020): (March 2020) Vol. 5 No. 2 (2019): (October 2019) Vol. 5 No. 1 (2019): (March 2019) Vol. 4 No. 2 (2018): (October 2018) Vol. 4 No. 1 (2018): (March 2018) Vol. 3 No. 2 (2017): (October 2017) Vol. 3 No. 1 (2017): (March 2017) Vol. 2 No. 2 (2016): (October 2016) Vol. 2 No. 1 (2016): (March 2016) Vol. 1 No. 2 (2015): (October 2015) Vol. 1 No. 1 (2015): (March 2015) More Issue