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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

Galenika
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Published by Universitas Tadulako

ISSN : 24427284 EISSN : 24428744 DOI : https://doi.org/10.22487/j24428744

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 241 Documents

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FORMULASI KRIM ANTIOKSIDAN EKSTRAK DAUN KAPAS (Gossypium sp.) Hasniar Hasniar; Yusriadi Yusriadi; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Gossypium sp. leaf is one of the plants that contain flavonoids that can act as antioxidants. This study aims to look at the effect of combination of the stearic acid and triethanolamine which function as emulsifier in creams and determine antioxidant activity of cream Gossypium sp. leaf extract. Cream is formulated with a variety of stearic acid and triethanolamine emulsifier that F1 (8%: 2%), F2 (12%: 3%), F3 (16%: 4%). Tests carried out at the first day and the 28th days. Evaluation preparations include organoleptic test, homogeneity, viscosity, pH, and type of the cream. The results showed that the variation of concentration emulsifier that fill quality preparations with some parameters such as organoleptic, homogeneity, the type of cream and viscosity. pH of cream does not qualify are 4.5-6, but still in the neutral pH range (pH ± 7). Antioxidant activity of the cream has a large reduce power at the first day DPPH reduce percent value for F1, F2, and F3 are 80,73%, 83,05% and 83,51% respectively, while after the storage at the 28th days DPPH reduce percent value for F1, F2, and F3 are 80,43%, 82,49% and 79,02% respectively. Preparation creams that fill physical quality cream is F1 by using emulsifier triethanolamine and stearic acid with a concentration of 8%: 2%

UJI AKTIVITAS ANTIDIABETES KOMBINASI GLIBENKLAMID DAN EKSTRAK DAUN SALAM (Syzygium polyanthumWight.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Steffi Liem; Yuliet Yuliet; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Pharmacological therapy of Diabetes Mellitus (DM) is to use antidiabetic oral. Herbal medicine are also often used as an alternative treatment by patients. Even in some cases found patients combine drugs and herbal medicine to speed up the healing of DM. This study aims to know the effects of a combination of glibenclamide and bay leaf ethanol extract (BLEE) to decrease blood glucose levels and to determine its optimal combination dose as antidiabetic. The method was inducted alloxan at dose of 120 mg/kg BW intraperitoneally. The animal test used were mice which divided into 8 groups of tests, the negative control (Na CMC 0,5 %), positive control (glibenclamide 0,65 mg/kg BW), combination 1(glibenclamide+BLEE 250 mg/kg BW), combination 2 (glibenclamide+BLEE 500 mg/kg BW), combination 3 (glibenclamide+BLEE 750 mg/kg BW), BLEE 1 (250 mg/kg BW), BLEE 2 (500 mg/kg BW), and BLEE 3 (750 mg/kg BW). After 14 days study, data were analyzed by ANOVA showed the difference in decrease of blood glucose levels combination 2 (230±23,69) mg/dL and combination 3 (233,75±9,93) mg/dL were significantly different to the negative control (4±6,82) mg/dL, positive control (150,75±11,34) mg/dL, combination 1 (170±10,51) mg/dL, BLEE 1 (134,5±4,61) mg/dL, BLEE 2 (151,25±6,72) mg/dL, and BLEE 3 (158,75±17,64) mg/dL. While combination 2 and combination 3 were not significantly different. Combination of glibenclamide and bay leaf ethanol extract decreased blood glucose levels greater than a single dosage glibenclamide or bay leaf extract. Optimal doses decreased blood glucose levels was combination 2.

ISOLASI DAN IDENTIFIKASI SENYAWA FLAVONOID DARI EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Siti Hamdanah; Syariful Anam; Jamaluddin Jamaluddin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Star fruits (Averrhoa bilimbi L.) from family of oxalidaceae is a plant which has potential as an antibacterial Staphylococcus aureus and Escherichia coli. Flavonoid are the active compounds from the extract of star fruit which has potential as an antibacterial. Star fruit were extracting by ethanol 96 % using maceration. Extract were identified using thin layer chromatography (TLC) with eluent analytic n-butanol- glacial acetic acid- water (6:1:3). Preparative isolation using thin layer chromatography resulting three bands. Each band was centrifuged to obtain isolates. Physics isolates were analyzing using spectrophotometer UV Vis and chemically using color test (shift reagent). UV Vis spectrum results with shift reagent from isolates 1, suspected as isoflavone compound with OH groups in position 6,7,4 and OH groups in O- ring A, in isolates 2 was not flavonoid compound and predicted as other polyphenolic compound and in isolates 3 suspected of flavone compound with OH groups in position 5,6,7 and OH groups in O-ring A

KAJIAN INTERAKSI OBAT PADA PENGOBATAN DIABETES MELITUS (DM) DENGAN HIPERTENSI DI INSTALASI RAWAT JALAN RSUD UNDATA PERIODE MARET-JUNI TAHUN 2014 Ida Nurlaelah; Alwiyah Mukaddas; Ingrid Faustine
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

One of the chronic complications of diabetes mellitus is a disorder of macrovascular as hypertension so that in it’s medicinal treatment required therapy with multiple drugs all at once that can lead to drug interactions. Drug interactions can result in increased toxicity and decrease the effectiveness of drugs that interact. This study aims to determine the prescription profile of DM patients with hypertension include the number of drugs prescribed, dosage forms, classes and types of drugs and the incidence of drug interactions theoretically, based on the mechanism drug interactions in outpatient installations of RSUD Undata Palu 2014. This design research is a non-experimental study with descriptive. Retrieval of patient data performed prospectively during the period from March to June 2014. Subjects who fill the inclusion criteria is adult patients that attain age of 18-60 years and diagnosed diabetes mellitus with hypertension are interview to obtain primary data while the secondary data such as medical records and prescriptions. Retrieved 61 sample. Based on dosage forms prescribe profile that most often given to the DM patients with hypertension was tablets (94.5%). Class of diabetes drugs most widely used is a sulfonylurea (21.1%) and hypertension drug classes beta blocker (12.2%). Types of diabetic drugs most widely used was glimepiride (14.2%) and hypertension was bisoprolol (9.2%). The percentage result of drug interactions theoretically was 85.2% (52 patients), drug interactions type that the most occured was pharmacodynamic interactions 72.7%. Diabetes melitus Patients with hypertension in outpatient installations of RSUD Undata Palu 2014 were most potentially subjected to drug interactions

UJI EFEK ANALGETIKA EKSTRAK BUAH KAKTUS (Opuntia elatior Mill.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT Gissa Amellia; Ihwan Ihwan; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Pain is a mechanism of body defense. One way to allay or decreasing the pain is using medicines that have analgetic effect. The aim of this study is determine the analgetic effect of cactus fruits (Opuntia elatior Mill.) extract and the most effective dose to giving analgetic effect. This study used writhing method by the injection acetic acid 1% as induced. Group I as a negative control used natrium carboxy methylcellulose 1%, group II as a positive control used aspirin suspension which dosage was 1,3 mg/20g BB, group III as a extract of cactus fruits give to dose 50 mg/kg BB, group IV dose 100 mg/kg BB, and group V dose 150 mg/kg BB. The result shows that cactus fruits extract to giving analgetic effect judging from the reduction strength writhing reflex to protection percentage at dose 50 mg/kg BB (11,26%), 100 mg/kg BB (42,10%), 150 mg/kg BB(60,14%) and the positif control (75,34%), at the positif control shows that higher protection percentage. Effectiveness percentage analgetic extract of cactus fruits at dose of 50 mg/kg BB (14,4%), 100 mg/kg BB (55,36%), 150 mg/kg BB (79,95%) and positif control (100%). The data which is got from the calculation later is analyzed by Kruskal Wallis. The result showed that at dose of 150 mg/kg BB is p: 0,016 (p<0,05) when compared with the positive control. So that is different significantly between dose 150 mg/kg BB and the positive control. The extract showed a optimal analgetic effect characterized by a significant reduction in the number of writhes or abdominal stretches in mice with dose 150 mg/kg BB body weight used when compared to the cactus fruits extract dose 50 and 100 mg/kg BB

FORMULASI SEDIAAN SABUN CAIR ANTIBAKTERI MINYAK ATSIRI DAUN KEMANGI (Ocimumamericanum L.) DAN UJI TERHADAP BAKTERI Staphylococcus epidermidis dan Staphylococcus aureus Febry Astuti Abu; Yusriadi Yusriadi; Muhammad Rinaldhi Tandah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Basil (Ocimum americanum L.) is a plant that has antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis that is a bacteria can cause infection. Basil contains essential oils that act as an antibacterial. This research aims to formulate the essential oil of basil leaves into a liquid soap, determine antibacterial activity against S.aureus and S.epidermidis bacteria with the agar diffusion method using wells and determine the stability of the preparation. Antibacterial activity data that gain was analyzed by one-way ANOVA with a level of trust 95% followed by Duncan test. The results of the research showed basil essential oil liquid soap preparation has antibacterial activity. The analysis results showed that there were significant differences in the concentration of 2%, 3%, 4%, and the Duncan test results showed no significant difference between the concentration of 4% with control (+). The results of the t-student analysis of liquid soap include viscosity, pH and dispersive capacity does not fill the parameters of stability during the storage period of 28 days

STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU BANGGAI DI KABUPATEN BANGGAI LAUT, PROVINSI SULAWESI TENGAH Nur Khairiyah; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

A study of nutritious herbs etnopharmacy has been done to Banggai ethnic from March to June 2015 in Banggai Laut Regency, Central Sulawesi. This research aims at identifying every kind of herbs parts used as traditional medicine, types of diseases cured using herbs by Banggai ethnic in Banggai Laut Regency, and the percentage of the usage by the informant about herbs as a traditional medicine. This is a descriptive research that uses qualitative method and take the sample purposively through open-ended interview involved 7 informants asked by questionnaire. The result of this research revealed that there are 54 types of herbs divided into 31 family used as medicine. The most widely used herbs is from 5 species of Zingiberaceae family and Lamiaceae family. Interview result revealed that there are 10 types of chronic diseases, 3 infectious diseases, non-communicable diseases 27, and 5 used for health care body. The parts of herbs used are leaf (49 percent), stem, sap, fruit, rhizomes, roots, tubers, herbs and bark. The Banggai ethnic precede the herbs through boiled, mashed, squeezed, shredded, soaked, brewed and then consumed, drunk, rubbed, pasted, applied directly. Processing methods most often done is boiled and drunk the herbs straightly. The higher belief the society has in the herbs ability to cure the diseases the higher use of herbal medicine as an alternative of diseases healing.

POTENSI EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK ETANOL UMBI BAWANG HUTAN (Eleutherine bulbosa) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmanii) PADA TIKUS (Rattus norvegicus) DIABETES YANG DIINDUKSI STREPTOZOTOSIN DAN TOLERANSI GLUKOSA Devyayu Prabaningsih; Yuliet Yuliet; Ririen Hardani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

Research on potential hypoglycemic effects of ethanol extract combination of onion forest bulbs (Eleutherine bulbosa) and burmani cortex (Cinnamomum burmanii) in streptozotocin (STZ)-induced diabetic and glucose tolerant rats (Rattus norvegicus) has been conducted. This study aimed to determine the hypoglycemic effect and the effective dose of ethanol extract combination of forest onion bulbs and cinnamon cortex. Extract was obtained by maceration using 96% ethanol. A number of 30 male rats were divided into 6 groups and each group consisted of 5 rats. The first group (negative control) was given Na.CMC; the second group (positive control 1) glibenclamide 0.45 mg/kgBW; the third group (positive control 2) acarbose 9 mg/kgBW; while the 4th, 5th, and 6th were successively given combination of ethanol extract of forest onion bulbs and cinnamon cortex at doses of 100+100, 50+50, and 25+25 mg/kgBW. Each rat group was intraperitoneally (ip) induced with STZ 40 mg/kgBW and then treated for 14 days, after the rats developed diabetic condition, glucose tolerance test was performed with the induction of sucrose 150mg/kgBW which was continued with observation in minute 60, 90, 120, 150, and 180. Treatment data were analyzed using ANOVA (analysis of variance) with 95% confidence interval. The results showed that ethanol extract combination of forest onion bulbs and cinnamon cortex had potential hypoglycemic effects in male rats of which the most effective combination dose was at a dose of 50 + 50 mg/kgBW

AKTIVITAS HEPATOPROTEKTOR SARI BUAH LABU KUNING (Cucurbita moschata Duchesne.) PADA TIKUS (Rattus norvergicus) YANG DIINDUKSIKAN KARBON TETRAKLORIDA Indrawan Aditya; Ihwan Ihwan; Jamaluddin Jamaluddin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

One of the plants that are often used in traditional medicine is the fruit of pumpkin used to treat hepatitis manner pumpkin fruit cut into small pieces and then steamed, then eaten .Pumpkin fruits contain active compounds such as saponins, tannins, flavonoids and beta-carotene. Beta-carotene is converted in the body into vitamin A is beneficial for the growth, maintenance of body tissues and to reduce the risk of cancer and heart disease. This study aims to determine pumpkin juice has a hepatoprotective activities on liver function by looking at parameters SGPT and SGOT in rats after induced CCl4. Type of experimental research using True Experimental research design design. Test animals were grouped into 5 groups, each group consisting of 3 rats. The first group of positive control (Methicol®), the second group negative control (CCl4), the third group of pumpkin juice 25%, the fourth group of pumpkin juice 50%, the fifth group of pumpkin juice 75%. From the results of this study concluded that the pumpkin juice 75% effective as a hepatoprotective by looking at parameters SGPT is 48 U/liter and SGOT is 66 U/liter in rats after induced carbon tetrachloride

PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Nur Hikmah; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

The use of herbal medicines and synthetic drugs simultaneously carried out by diabetics for the maintenance of blood glucose levels, such as the use of glibenclamide and bay leaf. This research was carried out to know the impact of administration bay leaf extract on glibenclamide in lowering blood glucose levels on mices that induced by alloxan. This research used 40 male mices which were divided into 8 groups. Before the experiment, the mices were first induced by alloxan (70 mg/kg BW) intravenously. The negative control was the group that given Na CMC 0,5%, KG was the control of glibenclamide 0,65 mg/kg BW, group DS1, DS2, DS3 were the control of single bay leaf extract with each dose 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW, group KD1, KD2, KD3 were the combination group of glibenclamide and bay leaf extract with each dose glibenclamide combined bay leaf extract 250 mg/kg BW, glibenclamide combined bay leaf extract 500 mg/kg BW, and glibenclamide combined bay leaf extract 750 mg/kg BW, with an hour interval. The data were statistically analyzed using ANOVA (Analysis of Variance) at 95% confidence interval with parameter of blood glucose levels difference between before and after treatment. The results showed that the administration of bay leaf extract gave significant impact on glibenclamide in lowering blood glucose levels and the effective dose was the combination of glibenclamide 0,65 mg/kg BW and bay leaf extract 250 mg/kg BW

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Muhammad Sulaiman Zubair

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Kota palu,

Sulawesi tengah

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Home Page

OAI Link

Editorial Team

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Contact Name Muhammad Sulaiman Zubair

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Phone +6285242083654

Journal Mail Official jurnalgalenika.farmasiuntad@gmail.com

Editorial Address Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location Kota palu, Sulawesi tengah INDONESIA

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Contact Name
Muhammad Sulaiman Zubair

Contact Email
sulaiman_zubair80@yahoo.co.id

Phone
+6285242083654

Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA