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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

Galenika
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Published by Universitas Tadulako

ISSN : 24427284 EISSN : 24428744 DOI : https://doi.org/10.22487/j24428744

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 12 Documents

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Search results for , issue "Vol. 5 No. 2 (2019): (October 2019)" : 12 Documents clear

Mutu Minyak Jelantah Dengan Adsorben Biji Salak (Salacca zalacca (Gaertn.)Voss) menggunakan Parameter Bilangan Peroksida dan Asam Lemak Bebas: Quality of Used Cooking Oil With Snake Fruit (Salacca zalacca (Gaertn.) Voss) Seed Adsorbent Using Parameters of Peroxide Value and Free Fatty Acids Ihwan Ihwan; Fadlia Fadlia; Syariful Anam
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Quality of used cooking oil with snake fruit (Salacca zalacca (Gaertn.) Voss) seed adsorbent has been conducted. This study aims to determine the ability of snake fruit seed in reducing peroxide value and free fatty acids in used cooking oil which can improve the quality and extend usage lifespan of the used cooking oil. The oil sampled in this study was packaged cooking oil which is usually used to fry food untill 7th frying. The oil was then neutralized using snake fruit activated charcoal. The test refers to the Indonesian National Standard (SNI) 7709: 2012 as the quality requirements of cooking oil. The results showed that snake fruit activated charcoal can reduce peroxide value as much as 56.18% and free fatty acid 76.04% in the used cooking oil.

Analisis Pektin Albedo Buah Jeruk Pamelo sebagai Adsorben Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu): Pectin Analysis of Pamelo Citrus Albedo (Citrus maxima (Burm.f) Merr.) as Adsorbent of Heavy Metal Plumbum (Pb), Cadmium (Cd) and Copper (Cu) Tahir, Masdiana; Safitri, Ineks; Suhaenah, Asriani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Pamelo citrus is a fruit plant having the potential to be developed in Indonesia. One of the centers for producing large oranges or Pamelo citrus in South Sulawesi is Pangkep Regency. One of the components of the Pamelo citrus is pectin. Pectin is a polysaccharide compound with a high molecular weight which is widely found in plants and it can absorb metals because they contain carboxylic groups. This study aimed to analyze pectin from albedo pamelo citrus fruit as an adsorbent for heavy metal plumbum (Pb), cadmium (Cd) and copper (Cu). The method used was atomic absorption spectrophotometer with the equation analysis of heavy metal adsorption by pectin of pamelo citrus determined by Langmuir and Freundlich adsorption isothermal method. The results showed that pectin of albedo pamelo citrus following the isothermal of Freundlich adsorption which showed the adsorbent capacity of Pb, Cd and Cu with the KF values 0.561 mg/g, 0.010 mg/g and 0.066 mg/g, respectively. Meanwhile, n values were 0.823 for Pb, 0.321 for Cd and 1.121 for Cu, and in commercial pectin following the isothermal of Freundlich adsorption with the KF values of Pb, Cd and Cu were 0.650 mg/g, Cd 0.015 and Cu of 0.77 mg/g, respectively. Then the n values were 0.641 for Pb, 0.811 for Cd and 1.183 for Cu.

Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv: Antibacterial Activity of Rosella Calyx Extract Encapsulated by Maltodextrin and Its Sinergity with Isoniazid and Rifampicin Against Mycobacterium tuberculosis H37rv N. Djide, Nana Juniarti; Djide, M.Natsir; Amir, Muhammad Nur; Sartini, Sartini
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

First-line drugs (Isoniazid and Rifampicin) for the treatment of tuberculosis are known to have experienced resistance to Mycobacterium tuberculosis. The aim of this study was to determine the minimum inhibitory concentration (MIC) of maltodextrin encapsulated rosella calyx extract and its ability to provide a synergistic effect with Isoniazid (INH) and Rifampicin (RIF) on M. tuberculosis R37rv. Rosella calyxs were macerated using 50% ethanol and encapsulated using maltodextrin. Antibacterial activity was carried out by determining MIC value using Microscopic Observation and Direct Susceptibility (MODS) method. The synergistic effect was carried out by calculating the Fractional Inhibition Concentration Index (FICI). The results showed that this extract was able to inhibit M. tuberculosis H37rv with MIC of 10 mg/ ml. The FICI value of the combination of extract with INH and rifampicin was obtained 1.25. This showed that rosella calyx extract is not synergistic with INH and rifampicin, might be due to rosella calyx extract has an antibacterial effect with a different mechanism with INH and Rifampicin.

Profil Penggunaan Obat Antidotum Di Rumah Sakit Umum Daerah Undata Provinsi Sulawesi Tengah Periode 2016-2018: Profile of Using Antidotum at Undata General Hospital Central Sulawesi Province Periode of 2016-2018 Mukaddas, Alwiyah; Faustine, Ingrid; Ulti, Putri Hijjah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Antidotes drug is indicated in intoxication or poisoning patients, in addition to the antidote drugs, it can also be used as an appropriate therapeutic indication of his own medicine. The high increasing number of the antidote drug used every year in inpatient instalation Undata hospital, for exmple atropine, N-acetylcysteine and pyridoxine (vitamin B6). Therefore, this study aims to determine the percentage of drug use of antidote category indicated as an antidote therapy in Undata hospitals Central Sulawesi Province period 2016-2018. This is a descriptive study with retrospective approach and using purposive sampling techniques.The results showed that the sample size was 75 patients, with the percentage of drug use as antidotes category in Undata Hospital Central Sulawesi province period 2016-2018, namely pyridoxine (vitamin B6) of 49.33%, N-acetylcysteine drug of 42.66% and the atropine drug of 8%. The use of antidotes drug category are indicated as an antidote to the poisoning therapy drugs obtained 0%. It can be concluded that there is no antidote drug category that used as an antidote therapy on patients with drug poisoning in inpatient instalation Undata hospital Central Sulawesi Province Period 2016-2018.

Formulasi dan Analisis Nilai Gizi Bakso Kotak dari Jamur Tiram Putih (Pleurotus Ostreatus): Formulation and Analysis of Nutritional Value of Square Meatballs from White Oyster Mushroom (Pleurotus ostreatus) Lamadjido, Sri Rahayu; Umrah, Umrah; Jamaluddin, Jamaluddin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Meatballs are processed meat products that very popular in Indonesia. Making meatballs is not just using animal material only, but also can be used plant materials such as oyster mushrooms. The meatballs can be made in various forms, such as a round shape or a box shape. This study aims to determine the nutrient content (moisture, ash, fat, protein, and carbohydrates) in several formula meatballs box of oyster mushroom (Pleurotus ostreatus) and find the best formula on the meatballs box oyster mushrooms, the nutrients (fat, protein, and carbohydrates), as well as the ash and moisture content. The study was designed using completely randomized design (CRD), which consists of six treatments and two replications. Parameters measured were as hedonic organoleptic include color, aroma, flavor and texture, using 15 panelists and nutrient analysis includes the levels of fat, protein, carbohydrate, ash content and water content. The results showed that the formulation of meatballs box, panelists preferred the formula II from another formula with a value of 3.06 based on color, aroma, flavor, and texture. The results of nutritional analysis were fat content of 0.77, protein content of 16:28 value, carbohydrate content of 31.4, ash content of 1:46 and water content of 9.44.

Studi Fisikokimia Betasianin Dalam Kulit Buah Naga dan Aplikasinya Sebagai Pewarna Merah Alami Sediaan Farmasi: Physicochemical Study of Betacyanin from Dragon Fruit Rind and Its Application as Natural Dye for Pharmaceutical Dosage Form Asra, Ridho; Yetti, Rina Desni; Rusdi, Rusdi; Audina, Selly; Nessa, Nessa
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

The rind of dragon fruit (Hylocereus lemairel (Hook.) Britton & Rose) is a waste material that has not been optimally utilized. The rind contains betacyanin pigment that has many benefits in pharmaceutical products. The study aimed to characterize the physicochemical properties, to evaluate the stability and to apply betacyanin in dragon fruit rind as a natural dye. The extraction process was done by using water as solvent which was sonicated at 50 kHz for 30 minutes at 25 Â°C. Extract was freeze dried for 48 hours. The dried extract was purified by using preparative TLC and physicochemically analyzed by using UV-Vis and FTIR spectrophotometer. The stability of betacyanin extract against pH and temperature was examined and applied as a dye in tablet imprinting. The result of this study indicated that betacyanin was found at Rf value of 0.6 same as the betacyanin standard. The maximum wavelength of betacyanin was obtained at 534 nm and the IR spectra showed similarity with betacyanin standard with the same functional groups between 4000-600 cm-1 although there was a slight shift in the wavenumber but it still in the range. The stability study were stable at temperature below 40 Â°C and at range pH 4-6. Betacyanin applications as natural dye of tablet have been successfully carried out with good color stability during 3 months of storage at room temperature.

Pengaruh Metode Ekstraksi Terhadap Rendemen Dan Kadar Fenolik Ekstrak Tanaman Kayu Beta-Beta (Lunasia amara Blanco): (The Effect of Extraction Method on Yield Value and Phenolic Content of Beta-Beta (Lunasia amara Blanco) Bark Extract Hasnaeni, Hasnaeni; usman, suriati; Wisdawati, Wisdawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Lunasia amara Blanco bark belonging to the family Rutaceae. The research aimed to determine the effect of extraction method on yield value and phenolic content of bark extract of Lunasia amara Blanco by UV-Vis spectrophotometry. Sample was extracted by maceration, reflux, and soxhlet using methanol 70%. The extraction by maceration obtained the yield value of methanol extract of 2,352%; the reflux method of 1,611%; and the soxhlet method of 0,960%. Then the chemical content was identified by the addition of FeCl3 reagent and a blackish green color was formed positively indicating phenolic content. Afterward, phenolic identification was conducted by TLC with eluent n-hexane: ethyl acetate (2:8) containing phenolic because the Rf value was the same as the galic acid standard. The results showed that the extraction method producing the highest yield of bark extract of Lunasia amara Blanco was maceration. The phenolic content obtained by maceration was 66,548 mgGAE/g extract with 6.6548% GAE; the reflux was 73.645 mgGAE/g extract with 7.3645% GAE; and the soxhlet was 74.806 mgGAE/g extract with 7.4806% GAE.

Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C: Immunomodulatory Effects of Ethanol Extract of Melophlus sarasinorum Sponge Against Phagocytosis Activity of Macrophage Cells on Balb/C Male Mice Wahyuni, Wahyuni; Yusuf, Muhammad Ilyas; Malik, Fadhliyah; Lubis, Adryan Fristiohady; Indalifiany, Astrid; Sahidin, I
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Immunomodulator is an ingredient or drug that can modulate immune system functions and activities. This study was conducted to determine the effect of ethanol extract of Melophlus sarasinorum sponge on macrophage phagocytosis activity. Twenty four male mice balb/c were divided into six groups. The first group received 100 mg/kg of ethanol extract of Melophlus Sarasinorum sponge, the second group received 200 mg/kg of ethanol extract of Melophlus sarasinorum sponge, the third group received 300 mg/kg of ethanol extract of Melophlus Sarasinorum sponge and the fourth group received 400 mg/kg of ethanol extract of Melophlus Sarasinorum sponge. The positive control group received Phyllanthus niruri linn extract (StimunoÂ®) 0,13 mg/g and the negative control group received NaCMC 0,5%. The extract was orally administered from first day to seventh day. On the eighth day, each of the mice was injected Staphylococcus aureus bacteria (SA) 0.5 mL intraperitoneally. Macrophage cell activity is calculated from smears of peritoneal fluid of mice. Increased doses of ethanol extract of Melophlus sarasinorum sponge increase the amount of macrophage phagocytosis activity that are 25,25% (negative control), 61,5% (positive control), 55,75% (100 mg/kg), 60,75% (200 mg/kg), 62,25% (300 mg/kg) dan 66,25% (400 mg/kg). The results showed that the ethanol extract of Melophlus sarasinorum sponge has the potential as immunomodulator at a doses of 300 mg/kgBB and 400 mg/kg with no significantly different effectiveness with positive control in increasing macrophage cell phagocytosis activity based on the result of post-hoc statistical test of Tukey (sig.> 0,05).

Uji Daya Hambat Formula Gel Ekstrak Etanol Daun Murbei (Morus alba L.) Sebagai Anti Acne Terhadap Bakteri Propionibacterium acne.: Inhibition Test of Ethanol Extract Gel of Mulberry (Morus alba L.) Leaves as an Anti Acne on Propionibacterium acne Bacteria Aliah, Ahmad Irsyad; Wahyuni, Wahyuni; Bachri, Nurjannah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

A research on the inhibition of formula gel test ethanol extract of leaves of mulberry (Morus alba L.) as an anti-acne against bacteria Propionibacterium acne. This study uses a gel formulation made using mulberry leaf extract (Morus alba L.), which aims to determine the inhibition of antibacterial gel mulberry leaf extract (Morus alba L.) against the bacteria Propionibacterium acne. Gel made three dosage concentrations of 2%, 4% and 6%. Testing inhibition of antibacterial gel agar diffusion method. Test Antibacterial inhibition obtained by looking at the clear zone in the medium and measured using calipers. The results showed that the inhibition of antibacterial gel formulation with a concentration of 2%, 4% and 6% showing that inhibiting bacterial activity.

Aktivitas Antioksidan Ekstrak Etanol Buah, Daun, Batang Dan Rimpang Pada Tanaman Wualae (Etlingera Elatior (Jack) R.M Smith) (RECTRACTED): Antioxidant Activity of Ethanol Extract of Fruits, Leaves, Stems and Rhizome of Wualae (Etlingera elatior (Jack) R.M Smith) (RECTRACTED) Jabbar, Asriullah; Wahyuni, Wahyuni; Malaka, Muh Hajrul; Apriliani, Apriliani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

This paper is retracted by editor because it has been published in another journal Wualae (Etlingera elatior (Jack) R.M Smith) is one of the plants in the Zingiberaceae family, widely used in medicine ranging from rhizomes, fruits, and flowers. Empirically Wualae are usually used by people for treating skin diseases, flavoring food, a natural soap, and in Southeast Sulawesi, it is used to treat typhoid fever. This study aims to examine the antioxidant activity of Wualae (Etlingera elatior) plant. The plant extracts were extracted by maceration method, antioxidant activity test was performed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The results showed that ethanol extracts of fruits, leaves, stems and rhizomes of Wualae (Etlingera elatior) has the potential antioxidant activity with the IC50 values of 72.518 mg/L, 99.890 mg/L, 52.345 mg/L and 58.638 mg/L, respectively. and Vitamin C has IC50 value of 3,787 mg/L.

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Muhammad Sulaiman Zubair

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jurnalgalenika.farmasiuntad@gmail.com

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Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

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Kota palu,

Sulawesi tengah

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Muhammad Sulaiman Zubair

Contact Email sulaiman_zubair80@yahoo.co.id

Phone +6285242083654

Journal Mail Official jurnalgalenika.farmasiuntad@gmail.com

Editorial Address Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location Kota palu, Sulawesi tengah INDONESIA

Abstract

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Contact Name
Muhammad Sulaiman Zubair

Contact Email
sulaiman_zubair80@yahoo.co.id

Phone
+6285242083654

Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA