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INDONESIA
Journal of Medical Biomedical and Applied Sciences
Published by Innovative Journal
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Arjuna Subject : -
Articles 15 Documents
 1   2 
Search results for , issue " Vol 1 (2014)" : 15 Documents clear
Antihyperglycaemic and Hepatoprotective Effect of Phyllanthus Emblica Fruit in Diabetic Animal Model M, Mittal
Journal of Medical Biomedical and Applied Sciences Vol 1 (2014)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.18

Abstract

The present study is aimed to evaluate the antihyperglycemic activity of ethanolic extract of Phyllanthus emblica fruits in alloxan in-duced diabetic rats. Whistar rats were made made diabetic with alloxan and ethanolic extract of P.emblica is administred in a dose of 100mg/kg and 150mg/kg body weight for antidiabetic activity. Blood glucose levels were estimated in all groups on 0, 10th, 20th, 30th day of treatment with P.emblica. The cholesterol, triglycerides, AST, ALT, ALP were estimated on 30th day of treatment in all group compared against diabetic control group. The ethanolic extract of fruit of P.emblica 100mg/kg & 150 mg/kg body weight showed dose dependenent reduction in blood glucose level in alloxan induced diabetic rats, cholesterol, triglyceride and other hepatic markers are also reduced when treated with ethanolic extract of P.emblica in alloxan induced diabetic rats. 
Risk Factor Analysis for Cardiovascular Diseases in Pregeriatric Type 2 Diabetes Mellitus Subjects U, Iyer
Journal of Medical Biomedical and Applied Sciences Vol 1 (2014)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.19

Abstract

Pregeriatric type 2 diabetic subjects were enrolled to identify the various risk factors for cardiovascular diseas-es. The risk factors analysis on 120 diabetic subjects showed a high prevalence of overweight, obesity, abdo-minal obesity, hypertension and metabolic syndrome. Poor metabolic control as evident from HbA1c was seen in 60% of the diabetic subjects. Dyslipidemia was a common feature. Majority of the subjects had 4-8 risk fac-tors and the most prominent risk factors were overweight/obesity, abdominal obesity, hypertension and low HDL-C levels. The multiple risk factor scenario highlights the need to improve the lifestyle patterns of the pop-ulation to reduce the risk of cardiovascular diseases.
Randomized Double Blind Comparison of Two Brands of Clopidogrel in Inhibition of Platelet Aggregation AA, Azeemi
Journal of Medical Biomedical and Applied Sciences Vol 1 (2014)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.20

Abstract

To compare the anti platelet effects of locally manufactured clopidogrel with the anti platelet effect of clopido-grel manufactured by multinational pharmaceutical abroad.
Antioxidants of Eichhornia crassipes: The World’s Worst Aquatic Weed N, Lata
Journal of Medical Biomedical and Applied Sciences Vol 1 (2014)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.21

Abstract

The recent revival of interest in plant medicines across the globe and consequent pressure on precious herbal resources, calls for the use of plants through scientific screening and validation. Free radicals and reactive oxygen species (ROS) have aroused significant interest among scientists in the past decades. Their broad range of effects on the biological systems causing various diseases has drawn attention of many experimental works. The world’s worst aquatic weed Eichhornia crassipes usually ranges from tropical desert to subtropical or warm temperate desert to rainforest zones. Ascorbic acid (vitamin C) one of the most extensively studied anti-oxidants has been detected in majority of plant cell types. Compounds of Quinones like anthraquinone considered to be a chemical antioxidant and possible therapeutic agents. Therefore, present investigation was planned to detect the presence of two bio-active compounds viz. Ascorbic acid and Quinones in the shoot and rhizome of Eichhornia crassipes by Thin Layer Chromatography (TLC) technique. The result obtained indicates that though plant is an aquatic weed is good services of phytochemicals needed for mainten-ance of good health, can also be exploited in manufacture of drugs. Its screening and scientific evaluation proves beneficial for the mankind along with the management of the plant.
Functionality Improvement of Gemfibrozil Formulations by QbD Approach A, Mukharya
Journal of Medical Biomedical and Applied Sciences Vol 1 (2014)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.22

Abstract

Die fill problem is encountered in production batches if the flow of the blend is not optimum. The flow of the blend is related to the characteristics of granules. The aim of this study was to formulate solid dosage form of gemfibrozil. Gemfibrozil is a waxy, crystalline, hydrophobic material that results in prolongation of disintegration time during storage in stability studies. Because of the fluffy nature of API flow problem was also encountered. Product and process characteristics important to desired performance must be derived from combination of prior knowledge and experimental assessment during product development, which is re-quired to achieve objectives of Quality by Design (QbD). From prior knowledge and experimental data, a multivariate model link-ing product and process measurements and desired attributes was constructed. Flow of gemfibrozil blend was improved by addi-tion of colloidal silicone dioxide, selecting microcrystalline cellulose of higher particle size and by producing granules of suffi-cient strength. Since the major portion of the tablet was gemfibrozil, the role of particle characteristics was also investigated.

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