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INDONESIA
Journal of Medical Biomedical and Applied Sciences
Published by Innovative Journal
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue " Vol 5 No 04 (2017)" : 2 Documents clear
The Ultimate Solution of any JOINT –PAIN (Coservative) JOINT-CURE Harbal for Osteoarthitis, Rheumatoid Arthritis, Backache due to Facet Arthritis, Spondilytis and Other Joint Pain Patel, Shahil
Journal of Medical Biomedical and Applied Sciences Vol 5 No 04 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.083 KB) | DOI: 10.15520/.v5i04.61

Abstract

Abstract: Aim:Why we get PAIN???Do we exercise every day?Do we have proper diet, water, air?How many of us are using PAIN KILLER MEDICINE daily?Without knowing the fact of PAIN Killer safety.....To find the effectiveness, Randomise Clinical trials with the Use of the JOINT -CURE herble"Churna" as an alternative treatment to any invasion in joints for the Pain relief ofOsteoarthritis, Rheumatoid arthritis, Facet Arthritis and / or any kind of Joint Pain.
Suberoylanilide Hydroxamic Acid (SAHA) with Antioxidant vitamin E: Induces ER Stress Pathway in Human Cervical Cancer Cell Line Sharma, Monal
Journal of Medical Biomedical and Applied Sciences Vol 5 No 04 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.488 KB) | DOI: 10.15520/.v5i04.62

Abstract

Suberoylanilide hydroxamic acid (SAHA) is a targeted inhibitor of histone deacetylase, which has been reported to inhibit cell growth, induce apoptosis in a variety of tumor cells and shown to be an anti-cancer agent. This study describes the anti-tumor effect of SAHA alone and in combination with antioxidant vitamin E in human epithelial cervical cancer (HeLa) cells. Cell cycle analysis of drug HeLa cells showed slight decrease in cell population at the G1 phase, and increase at the G2/M Phase with concomitant decrease in S phase. We also observed SAHA induce anti-proliferative effect in a dose dependent manner and caused DNA fragmentation. Expression of CHOP and Bax/Bcl-2 Ratio were found to be augmented after post treatment. Level of Reactive oxygen species (ROS) was increased and antioxidant enzyme catalase activity was decreased after treatment, suggesting that SAHA induced apoptosis is an endoplasmic reticulum stress pathway. This study provides a better understanding of molecular mechanism of anti- tumor effect of SAHA and gives insight of the development of better undersigned combinatorial chemotherapy strategies.

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