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INDONESIA
Journal of Medical Biomedical and Applied Sciences
Published by Innovative Journal
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Arjuna Subject : -
Articles 3 Documents
 1 
Search results for , issue " Vol 5 No 3 (2017)" : 3 Documents clear
WHY PAIN ??? Patel, Shahil
Journal of Medical Biomedical and Applied Sciences Vol 5 No 3 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.084 KB) | DOI: 10.15520/.v5i3.50

Abstract

Most of us are having trouble like pain either at the starting of our day while wake-up from bed either due to lack of sleep/ inadequate diet and water etc. or at the end of our work while moving from office and/ or at the home after having terrible work at home as compare to office work.
Periodontal approach to improve Aesthetics : A Case Report Vellayappan, Radha
Journal of Medical Biomedical and Applied Sciences Vol 5 No 3 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (468.489 KB) | DOI: 10.15520/.v5i3.51

Abstract

A variety of factors including teeth form/position and gingival tissue levels may influence the overall smile aesthetics [1, 2]. In the last decade a great interest was focused on plastic periodontal surgery as a reliable tool to enhance esthetics
More insight into the mode of action of lipophilic antitumor drugs containing a platinum (II) fragment Vanchanagiri, Kranthi
Journal of Medical Biomedical and Applied Sciences Vol 5 No 3 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1114.774 KB) | DOI: 10.15520/.v5i3.54

Abstract

Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)) (Carboplatin 2) is a second generation platinum anticancer drug following Cis-diamminedichloroplatinum(II) (Cisplatin 1). In the present study Cisplatin and Carboplatin analogs are attached to the acid group of the bile acid via an ester link called as ChAPt(n)Cis and ChAPt(n)Carbo. The in vitro antitumor activity of Cisplatin 1 along with the corresponding ChAPt derivatives evaluated against a panel of five tumor cell lines of different histogenic origin. A series of biological methods starting from Sulforhodamine B (SRB) assay to determine IC50, Cell cycle analysis, Annexin-V assay and Caspase assays were performed with the aim to scrutinize the anticancer mode of action on HepG2 (hepatocellular car cinoma) cell line. The compounds exerted a dose dependent antiproliferative action at micro molar concentrations and the effect of these structural variations on anticancer activity was elaborated and discussed more in detail. To summarize, several compounds revealed significant antitumor activity and surprisingly the ChAPt(11)Cis and ChAPt(11)Carbo induce programmed cell death with molecular features different from each other, suggesting that both drugs induce apoptosis through different initial pathways.

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