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Journal of Medical Biomedical and Applied Sciences

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Published by Innovative Journal

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Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Articles 6 Documents

Search results for , issue " Vol 6 No 6 (2018)" : 6 Documents clear

Effects of Co-Administration of Lycopene and / or Zinc on Serum Electrolyte In Alloxan- Induced Diabetic Wistar Rat A.D.T, Goji; K.A, Muhammed; J.A, Tende; I, Aisha
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

Background: The incidence of diabetes is increasing rapidly with interference in electrolytes sodium (Na+), potassium(K+) and chloride (Cl-). This work was designed to study the effects of co-administration of Lycopene and/or Zinc onSerum Electrolyte in Alloxan- Induced Diabetic Wistar Rat.Material and Methods: Healthy albino rats weighing between 150g and 200g were used. The rats were randomlyallotted into six groups, each containing five albino rats respectively. Five of the groups ( II,III IV V and VI) were inducedwith diabetes by single intraperitoneal (i.p) injection of freshly prepared in 0.1 mol/L citrate buffered solution (pH 4.5)of streptozotocin (Sigma Aldrich, St. Louis, MO, USA) at a dose of 150 mg/kg body weight. Control (vehicle) rats wereinjected with equal volume of 0.1 mol/L citrate buffer. Four days after Alloxan injection, diabetes induction was confirmedby measuring fasting blood glucose level in a tail vein blood samples using ACCU-CHEK compact plus glucometer(Roche, France). Rats with glucose level of 200 mg/dl or higher were considered as diabetic. After the induction ofdiabetes the rats were treated using the Lycopene and Zinc separately and in combination respectively according togroup daily, whereas, the other group (I) was not given any treatment and this served as the normal control, providinga baseline data.Results: The diabetic treated groups had significantly (P < 0.05) higher serum Na+ concentration than the diabeticcontrol group. The diabetic treated groups had significantly (P < 0.05) lower serum K+ concentration than the diabeticcontrol. Also, the diabetic treated groups had significantly (P < 0.05) higher Clô concentration than the diabetic controlgroup. The diabetic treated group had significantly (P < 0.05) lower HCO3ô concentration than the diabetic controlgroup. The diabetic treated groups had significantly (P < 0.05) lower serum urea concentration when compared to thediabetic control. The diabetic treated groups showed significantly (P < 0.05) decrease in serum creatinine concentrationas compared to the diabetic control group.Conclusion: These anomalies were all ameliorated to about normal values after four weeks of treatment withLycopene+Zinc. This suggests the synergistic beneficial effects of lycopene acid and zinc against alloxan-induceddiabetes in Wistar Rats.

Riboflavin Is Ineffective For Maternally Inherited Mitochondrial Disease Finsterer, MD, PhD, Josef; Mahjoub, PhD, Sinda Zarrouk
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

With interest we read the article by Darin et al. about 13members of a family carrying the m.3250T>C mutation inthe tRNA(Leu) gene on the mitochondrial DNA1. Two ofthese patients were systematically treated with riboflavin butwithout a beneficial effect1. We have the followingcomments and concerns.

Mitochondrial Multiorgan Disorder Syndrome (Mimods) Due To Mutations In The Slc25a46 Gene Finsterer, MD, PhD, Josef; Zarrouk-Mahjoub, PhD, Sinda
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

In a recent article, Braunisch et al. reported about 4 patients(VI-5, VI-4, II-3, II-4) with pontocerebellar hypoplasia(PCH) due to mutations in the SLC25A46 gene1. We havethe following comments and concerns

Total Ischemic Time Versus Door-To-Balloon Time As An Outcome Predictor In St-Elevation Myocardial Infarction Sigal, MD, Adam; Rajagopalan, MD, Priya; Fadahunsi, MD, Opeyemi; Koslow, MD, Michael; Wasser, PhD, Tom; Mengel, RN, Vanessa Cambria; Barbera, MD, Charles
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

BACKGROUNDAcute Coronary Syndrome is a common presenting condition to the emergency department and early reperfusiontherapy for patients with an ST-Elevation Myocardial Infarction (STEMI) with Percutaneous Coronary Intervention is therecommended treatment. The American Heart Association / American College of Cardiology has a 60 minutes goal forrestoration of coronary flow from the time of patient arrival.OBJECTIVETo review the impact of rapidly identifying STEMI patients and expediting transfer to the interventional cardiology suiteon restoration of blood flow times and metrics of cardiac injury, such as peak troponin and ejection fraction. To reviewthe impact of total ischemic time on similar metrics.METHODSWe conducted a single site retrospective review on STEMI patients undergoing the expedited process for reperfusioncompared to standard process.RESULTSExpedited transfer of patients to the cardiac catheterization suite resulted in significantly lower door-to-balloon times forpatients undergoing the âdrive-byâ process (mean 31.03, SD 4.05 vs mean 68.72, SD 45.09, p < 0.001), compared tousual care. The improved times, however, did not translate into improved metrics of peak troponin value or LVEF. Therewas a significantly lower peak troponin level (mean 57.14, SD 86.51 vs 97.73, SD 152.43, p=0.017) and a greater LVEFpercent at six months (56.41, SD 10.46 vs 52.56, SD 11.93, p = 0.039) for those with < 4 hour symptoms than thosewith 4 hours of symptoms.CONCLUSIONSymptom onset to balloon time has a greater impact on cardiac morbidity than door-to-balloon time.

Diabetes Type 2 And Dysautonomies: Prospective Study Over 5 Years About 300 Cases HALIMA, Pr BENJELLOUN; YASSINE, Dr ERRAHALI; JAD, Dr ISSOUANI; SANAE, Dr CHAKDOUFI; SOUAD, Dr MOUSSAOUI; GHIZLAINE, Pr BELMEJDOUB; AHMED ANAS, Dr GUEBOUB
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

Rational - Diabetes is by far, the leading cause of vegetative neuropathy in the world. Dysautonomia is one of the major complications of diabetes, it is responsible for very diverse manifestations that can, in advanced forms, be responsible for major dysautonomia affecting several organs. Nevertheless, it has been suggested recently, that a sympathetic hyperactivity would be predictive of the onset of type 2 diabetes. Our goal was to examine the relationship between type 2 diabetes and dysautonomia.Patients and methods - This is a prospective descriptive study that took place over 5 years from June 2013 to June 2018, involving 300 non-hypertensive diabetic patients recruited at the endocrinology department of diabetology Mohammed V military hospital in Rabat.Results â The association between sympathetic hyperactivity and type 2 diabetes in non-hypertensives diabetics was confirmed in our study (pâ¤0.05). Male subjects were found to develop more sympathetic hyperactivity than female subjects (pâ¤0.05). Also, there was a significant correlation between vagal impairment and the age of diabetes (pâ¤0.05). Conclusion â The responsibility for sympathetic dysfunction in the genesis or aggravation of metabolic disorders is currently confirmed.

Importance of Serum Adiponectin Levels in The Prediction And Ethiopathogenesis of Intrauterine Growth Restriction KarlÃ„Â±, Pervin; BaÃ…ÂŸbuÃ„ÂŸ, Alper; KÃ„Â±lÃ„Â±ÃƒÂ§, ÃƒÂ‡iÃ„ÂŸdem; Kutluer, GÃƒÂ¼lÃ…ÂŸen; Artar, Ã„Â°shak; GÃƒÂ¼lerman, Hacer Cavidan
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

Objective: Our aim in this study is to determine the possibility that patients with IUGR (intrauterine growth retardation)will be able to look at the adenonetin levels in the early stages of pregnancy and to have IUGR. In this respect, earlydiagnosis, treatment and follow-up are aimed to reduce morbidity and mortality due to IUGRMaterial Method: The study was carried out between January and March 2010. Zekai Tahir Burak WomenÃ¢â¬â¢s HealthEducation and Research Hospital 28-40. with 89 patients aged 18-40 years. Groups 44 IUGR patients and 45 normalpregnant patients were divided into two groups. To examine the serum adiponectin level, an average of 3 cc was takenin the gel biochemistry tubes and then centrifuged at 4000 10 minutes. The resulting serum samples were collectedfor the ELISA kit and kept at -80 C until the day the patients were collected. In the study, adiponectin levels weremeasured by serum ELISA (enzyme linked immunosorbent assay) method.Results: In adiponectin evaluation, mean value was 105.90 19.02 pg / ml for the IUGR group, 65.96 16.5 pg / mlfor the control group and 1.6 times higher for the IUGR group( p < 0.001)Conclusion: In this study, the increased adiponectin levels of IUGR patients were significantly higher than those ofIUGR patients, suggesting that pregnancies of IUGR patients can be measured high in the first weeks and if IUGR ishigh in those weeks, IUGR can be predicted.

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