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Journal of Medical Biomedical and Applied Sciences

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Published by Innovative Journal

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Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Articles 4 Documents

Search results for , issue " Vol 7 No 1 (2019)" : 4 Documents clear

Cannabidiol Psychoactivity: A Perspective on Claims of US Patent 6630507 Dawson, David A
Journal of Medical Biomedical and Applied Sciences Vol 7 No 1 (2019)
Publisher : Journal of Medical Biomedical and Applied Sciences

The Department of Health and Human Services owns US Patent 6630507 which states that cannabinoids are powerfulantioxidants and have the potential to treat myriad ischemic, age-related, inflammatory, and auto-immune disorders. Thepatent claims cannabinoids are also a natural neuroprotectant which could help treat neurological damage caused bystroke and trauma, as well as other neurological disorders like Alzheimer’s, Parkinson’s Disease, and Multiple Sclerosis.This perspective paper assesses the properties and usefulness of the patented cannabinoid.

Comparison of Lingual and Buccal Orthodontic Therapy on Microbial Parameters and Periodontal Status Franch, M; Iglesia, F De La; Auladell, A; Walter, A; Clusellas, N; Puigdollers, A
Journal of Medical Biomedical and Applied Sciences Vol 7 No 1 (2019)
Publisher : Journal of Medical Biomedical and Applied Sciences

AbstractObjective: To compare the periodontal condition and the microbiological status between the vestibular group (VG), lingual group (LG) and control group (CG).Mataerial and Methods: 18 patients(mean age: experimental group: 32 years old; and control group: 25 years old): 6 treated with vestibular fixed appliance, 6 with lingual appliance and 6 subjects in the control groupwho did not receive orthodontic treatment. A periodontal exam was performed before placing braces (T0) and after 4 weeks (T1). The gingival index (GI), plaque index (PI), Bleeding on probing (BOP) and periodontal pocket depth (PPD) was evaluated. Through PCR was detected the presence or absence ofEikenellacorrodens (Ec), Fusobacterium nucleatum (Fn), Agregati bacteractinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Tannerella forsythensis (Tf), Terponema denticolla (Td), and Prevotella intermedia (Pi).Results: It was found a significant increased in the plaque index and gingival index. No significant changes were found according to BOP and PPD. The microbiological results show significant differences between the control group and the experimental groups in Aa, Tf, Pi, Fn and a tendency to an increase of Pg, Td in both experimental groups. Conclusions: There’s a direct relation between the placement of fixed appliance (vestibular and lingual) and the increase of plaque index and gingival index. Also, the growth of periodonto pathogens in subgingival plaque is promoted. Clinical relevance : This study stresses the importance of monitoring orthodontic patients. Vestibular orthodontic appliance seems to be better than the lingual in terms of less worsening condition during time.

Development and Characterization of Buccal Film: Tacrolimus as A Model Drug P, Ashwathy; R, Arjun; R, Raghavi; Anil, Anjitha; A Surendran, Saritha
Journal of Medical Biomedical and Applied Sciences Vol 7 No 1 (2019)
Publisher : Journal of Medical Biomedical and Applied Sciences

Buccal drug delivery has become a relevant route of administration. It has got various advantages, masking the firstpass metabolism being the primary one, thus ensuring increased drug bioavailability at the site of action. Tacrolimus,an immunosuppressant, calcineurin inhibitor is the drug of choice. Oral tablet suffers from high first pass metabolismand topical formulations such as ointments readily washout from the site of application. Tacrolimus formulated asmucoadhesive buccal film provided prolonged effect than topical formulations. Films (F1 & F2) were prepared bysolvent casting technique. Chitosan being the best mucoadhesive polymer with wound healing properties increased theretention time of the film at the wound site. HPMC ensured good film property. Propylene glycol was used as plasticizerand citric acid as salivary stimulator and cross linker. The compatibility of drug in the formulation was confirmed byFTIR. Formulated films were subjected to various evaluation parameters, and all the physical parameters were withinthe acceptable limits. In vitro release was found to be better for F1. Ex vivo studies of F1 using goat mucous showed apermeation of 76.5%.

Clinical, Etiologic And Evolutionary Characterization of Osteoarticular Infections in Children Hospitalized in A Referral Tropical Medicine Center Sanabria, Gabriela; Navarro, Andrés; Araya, Soraya; Arbo, Antonio
Journal of Medical Biomedical and Applied Sciences Vol 7 No 1 (2019)
Publisher : Journal of Medical Biomedical and Applied Sciences

Introduction: Osteoarticular infections (OAI) are an infectious pediatric pathology, generally of bacterial etiology, relatively frequent and potentially severe. Objective: To determine the clinical, etiological and evolutionary characteristics of osteoarticular infections in hospitalized children in a referral center. Materials and methods: Observational, retrospective cross-sectional study. We reviewed the medical records of all children from 1 month to 15 years of age hospitalized in the Pediatric Service of the Institute of Tropical Medicine (IMT) from 01/01/2010 to 12/31/2015 with diagnosis of osteomyelitis, Osteoarthritis or Septic Arthritis Results: A total of 59 children with an OAI diagnosis were hospitalized. 25 (42.4%) diagnosed with septic arthritis, 6 (10.2 %) polyatritis, 21 (35.6 %) osteomyelitis and 7 (11.9 %) osteoarthritis. The mean age was 8.9 + 3.8 years, 40 (67.8 %) were males. Pain and functional impotence were the most frequent symptoms. 47 (79.6%) were located in lower limbs. Staphylococcus aureus methicillin resistant (MRSA) 17 (41.5 %), methicillin sensitive Staphylococcus aureus (SAMS) 18 (43.9 %), Pseudomonas sp. 2 (4,9 %), Klebsiella pneumoniae BLEE 3 (7.3 %), another 5 (12,1 %). In this series 2 patients diagnosed with septic shock at the joint point (Hip and knee respectively) without germ isolation died. Conclusion: OAI remains to be pathology of high morbidity in our environment. They affect more often the lower limbs as well as school-age male children. The UAA was the most frequent isolated germ. The mortality rate is low and the sequelae continue to appear.

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