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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 6 Documents
 1 
Search results for , issue "Vol. 11 No. 4 (2023)" : 6 Documents clear
Study of risk factors in myopic individuals among medical students in Chennai, Tamil Nadu Arumugam, Seshadhri; Balabaskaran, S.; Abhilash, B. A.; Sowmiya, K.; Baalann, Krishna Prasanth; Surya, B. N.
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.10.14

Abstract

Background: The incidence of myopia is increasing at an alarming rate. Investigating the causes of myopia gives us a better understanding of it. This gives us better odds of preventing the occurrence and retarding the condition's progression. The study used a method called stratified sampling to select 100 individuals who were near-sighted. They belonged to the age of 17-30 years old and pursued medicine in the district of Kanchipuram. The role of risk factors was assessed through a questionnaire. Result: The percentage of subjects with low, medium, and high myopia was 77, 18, and 5, respectively. The role of heredity, diet, academic performance, time spent doing near work, and outdoor work was indeed found to play significant roles in the development and progression of myopia. Conclusion: The incidence of myopia is constantly increasing, especially in Asian countries. To prevent myopia and its complications, we need to take significant steps to reduce the risk factors that can be changed.
Case study of thyroid dysfunction associated with polycystic ovarian syndrome (PCOS) Kaavya M; Nithin Palanisami P S; Thakur, Rashmi; Saru Sree Mu
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.35.40

Abstract

Background: In recent times, there's a noticeable rise in endocrine dysfunctions, with increasing clinical resemblance between PCOS and autoimmune thyroid disease. The exact cause of this association remains uncertain, but these conditions share a reciprocal relationship. While they exhibit common clinical features, risk factors, and pathophysiological abnormalities, the root causes differ. Polycystic ovaries can be a manifestation of hypothyroidism, making it necessary to rule out hypothyroidism before diagnosing PCOS. Common factors like increased adipose tissue, insulin resistance, high leptin, and abnormal autoimmunity play a vital role in linking these conditions. These shared signs and symptoms emphasize the association between PCOS and hypothyroidism, though the etiopathological basis of this complex relationship is not fully established. Methodology: Cross-Sectional study of 200 patients involved after history, examination. Statistical analysis by SPSS v.22. Result: In this study, we aimed to evaluate thyroid function in PCOS patients using serum TSH levels and estimate the prevalence of hypothyroidism. We also examined prolactin levels in diagnosed PCOS patients, considering criteria like age distribution, BMI, clinical manifestations, fertility status, and thyroid status. Conclusion: Our findings suggest that PCOS is more prevalent in patients with thyroid disorders such as autoimmune thyroiditis and subclinical hypothyroidism compared to the general population. Additionally, PCOS increases the risk of cardiovascular diseases like hypertension and dyslipidemia. Subclinical hypothyroidism with PCOS further elevates the risk of hypertension compared to euthyroid PCOS patients. The study reveals that thyroid dysfunction occurs in 29.0% of PCOS patients, emphasizing importance of screening for thyroid abnormalities in PCOS patients.
Comparison of smartphone based peek visual acuity with Snellen Visual Acuity Dulani, Nisha; Dulani, Harish; De, Tapas Kumar
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.15.18

Abstract

Purpose: To test an alternative method of visual acuity assessment by comparing habitual and best-corrected visual acuity by Snellen and Peek (a visual acuity testing smartphone application). Methods: A prospective study comparing visual acuity using Snellen's and Peek's visual acuity charts (smartphone-based applications). 162 eyes were assessed in this hospital-based setting by a single observer. Patients with gross ocular pathology and visual acuity less than 6/60 were excluded from the study. Results: There was no statistically significant difference between best corrected visual acuity by Snellens and Peeks'. Snellen's mean best corrected visual acuity was 0.9902 (±0.075), and Peek acuity was 0.9875 (±0.080). Conclusion: The visual acuity assessment by Peek is comparable to that of Snellen's; hence, it can be used as an excellent alternative to Snellens' visual acuity testing.
Prevalence of methicillin resistant staphylococcus aureus and its SCCmec type among students at a private dental college hospital in Chennai Vinshia, Jebadass Jasmine; Padmavathy, Kesavaram; Sathyapriya, Baskaran; Sudha, Jimson
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.19.26

Abstract

Background: Since asymptomatic nasal carriage of Methicillin-resistant S. aureus (MRSA) is on the rise among healthcare professionals (HCPs), their prompt detection and decolonization would substantially decrease disease transmission. The study's primary goal was to identify MRSA nasal carriers among dental students/CRIs and determine their SCCmec type and their susceptibility to mupirocin. Methods: Anterior nasal swabs from 102 healthy dental students/ CRIs were collected aseptically and subjected to standard microbiological testing. The antibiotic susceptibility pattern of the S. aureus isolates was determined by Kirby Bauer disc diffusion method and mecA-mediated oxacillin (methicillin) resistance was determined using the cefoxitin disc method. PCR analysis of MRSA isolates determined the presence of mecA and their SCCmec types. D test deduced inducible clindamycin resistance. Results: Of the 102 participants screened, only 8(7.8%) carried S. aureus. Antibiotic susceptibility testing revealed that 5/8(62.5%) were MRSA isolates. Of which, only 2 MRSA isolates harbored mecA, and both belonged to the SCCmec type V. All S. aureus isolates were sensitive to Vancomycin, teicoplanin, and tigecycline when tested using agar screening method while 2/8 (25%) of the S. aureus isolates were D test positive and belonged to iMLSB phenotype. Conclusion: MRSA nasal carriers amongst HCWs/dental students are a cause of concern as they are a significant reservoir for transmission of MRSA among their co-workers as well as the community. Our results signify the need for screening for MRSA carriage and decolonization with mupirocin to substantially decrease the transmission of MRSA among dental students/patients.
Current trends and future perspectives of natural polymer loaded nanoparticle based drug delivery system for the management of inflammatory bowel disease Basak, Ankita; Ghosh, Soumyadip; Ganguly, Debgopal; Garain, Soukat; Ghosh, Riya; Choudhury, Ananta; Deka, Himangshu; Sarmah, Jahnabi
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.1.9

Abstract

Targeting the drug delivery system is very tough nowadays due to premature drug release at the upper GIT tract and altered pH conditions. Colon-specific drug delivery systems can overcome that problem using different polymer combinations. A nanoparticulate drug delivery system is the prominent dosage form that impacts the bioavailability and requires a low dose to excrete the therapeutic efficacy. All nanoscience and nanotechnology are applications of Nanometrology, the science of measurements at the nanoscale. NPDDSs were primarily developed to combine the colloidal stability of solid particle suspensions in biological fluids and the solubilizing properties of liquids. An ideal drug-delivery system possesses two elements: the ability to target and control the drug release. Colloidal drug carriers offer a number of potential advantages as delivery systems, such as better bioavailability for poorly soluble drugs. Researchers have created various sophisticated and multifunctional nanocarrier systems that can transport pharmaceuticals in a targeted, sustained, and regulated manner to provide therapeutic medications that are safer and more effective, particularly to ulcerative colitis. These innovative technologies are improving the pharmacokinetic profile of pharmaceuticals, increasing their systemic circulation, and decreasing the frequency of pharmacological side effects. The review focuses on the current trend and future perspectives of natural polymer-based-loaded nanoparticle-based drug delivery systems for the management of inflammatory bowel disease.
Green synthesis of ZnO nanoparticles using peels of Citrus limetta and evaluation of their antibacterial activity Thenmozhi, J R; S, Shahanaz; Manuel, Suba G A
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.27.34

Abstract

Background: The fruit peel wastes produced during the processing of different agriculture-related products after production are not utilized to their full potential, and their environmental impact has become a significant global issue. Citrus peel waste is rich in nutrients and has biopotential activity. Objective: The main objective of the current study is to analyze peels of Citrus limetta qualitatively and quantitatively and synthesize Zinc oxide Nanoparticles using the green synthesis method. Methodology: The synthesized ZnO NPs were characterized by UV-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), and Scanning electron microscopy (SEM). The antibacterial activity of C. limetta peels ZnO NPs against Pseudomonas aeruginosa was evaluated by the Agar Disc Diffusion method. Results: The UV-Vis spectrum was measured in the 200 – 400 nm range, and the crystalline structure was analyzed via XRD. SEM/EDS analysis confirmed the nano-spherical structures and the agglomeration of the synthesized ZnO NPs. A minimal inhibitory effect against the Pseudomonas aeruginosa by C. limetta peels ZnO NPs was observed. Conclusion: Hence, the green synthesized ZnO NPs offer an effective and economical way to utilize citrus peel waste in both food and non-food sectors.

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