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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS Kumar, Amrendra; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system. 
Novel drug delivery system: a promising approach in management of schizophrenia – A review Moin, Shaikh Gulam; Sharma, Neha; Rane, Meenal
Journal of Applied Pharmaceutical Research Vol 5 No 4 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0007

Abstract

Schizophrenia is a syndromic condition which is characterized by a set of signs and symptoms like delusions. It is severe non-curable illness of the brain. If not controlled and treated properly, it can lead to severe consequences. One can control these delusions by means of treatment, by using Conventional therapy or Novel therapy. There are various advantages of Novel system over Conventional system. This review focuses on understanding Novel system and its advantages over Conventional system.
Pharmacological screening of Alsotonia scholaris Rathor, Vinod; Wadhwa, Shailendra; Deb, Jyotirmoy; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

A large number of medicinal plants are claimed to possess anthelmintic property in traditional systems of medicine and are also utilize by ethnic groups worldwide. The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plant as an alternative source of anthelmintice. In the current study were conducted to determine the possible anthelmintic and antibacterial effects of leaves of Alstonia scholaris. The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases and ailments of human beings including anthelmintic activity.
Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
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Abstract

The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials   on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin. 
Domperidone Tablet: Short Review Sharma, Shaveta
Journal of Applied Pharmaceutical Research Vol 5 No 1 (2017)
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Abstract

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Oral delivery of active ingredients include a number of technologies, many of which may be classified as Orodispersible tablets (ODTs). Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. Domperidon is a  mouth dispersable tablet no sustainrelease tablet developed so far.sustain release tablet can be developed.
Acne: current perspective Kamra, Manju; Diwan, Anupama
Journal of Applied Pharmaceutical Research Vol 5 No 3 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0001

Abstract

Acne vulgaris or acne is a multi factorial chronic inflammatory disease of pilosebaceous unit. Globally it affects approximately 9.4% of the population. It is characterized by blackheads and white heads, pinheads, large papules which may lead to scarring. Other than scarring, its main effects are psychological, such as distress and reduced self-esteem. Up to 80% of teenage girls and 90% of teenage boys are afflicted with acne. Adult acne, although less common than adolescent acne, is a significant problem for 3% to 6% of adult men and 5% to 12% of adult women. It is the most common chronic skin disorders which require urgent attention. Successful treatment of acne requires careful selection of anti-acne agents.
Design and in vitro evaluation of mouth dissolving tablets olanzapine Sharma, Vivek Kumar; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
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Abstract

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets.  The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactory
Pharmacognostical and preliminary phytochemical screening of the corm of Stephania hernandifolia (Willd.) Walp. Sharma, Uttam; Nandi, R. P.
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

The aim of the study is to cover the pharmacognostical and preliminary phytochemical screening of the corm of Stephania hernandifolia (Willd.) Walp. Stephania hernandifolia (Willd.) Walp. belonging to the family Menispermaceae is a natural taxon. The plant was collected from the Darjeeling district of West Bengal, India, during summer and was authenticated by the botanist. Pharmacognostical study included macroscopical characters, microscopical characters, physico-chemical constants and fluorescence analysis. Preliminary phytochemical screening includes phytochemical extraction, phytochemical testing and thin layer chromatography (TLC). In macroscopical studies of the corm, it was found that, it’s shape was spherical, size was about 8 to 20 cm in length and 10 to 20 cm broad, colour was brown (Rusty), surface was rough, odour was not specific, taste was bitter, direction of growth was vertical, the surface has many circular and slightly raised spots. In microscopical studies of corm, it were found that it has periderm, vascular bundles, thin phelloderm cells, ground parenchymatous cells, dense masses of starch grains and wide circular secretory cavities were seen. In powder microscopy, sclereids and vessel elements have been observed with short sclerenchyma. Physico-chemical parameters like total ash value (13 % w/w), acid insoluble ash value (2.66 %w/w), water-soluble ash value (2.50 %w/w) and sulphated ash value (3.33 %w/w) were observed. Alcohol soluble extractive value (7.23 %w/w), water-soluble extractive value (10.84 %w/w) were also observed and loss on drying was observed as 2.50 %w/w. The foaming index was found to be 111.11. Preliminary phytochemical studies show the presence of alkaloids, carbohydrates, Steroids, Saponin, tannin and phenolic compounds flavanoids, and lignin in ethanolic extract and carbohydrates, Saponin, tannin and phenolic compounds flavanoids, and lignin in aqueous extract. Performing TLC of ethanolic extract using chloroform: ethanol (30:70) and methanol: water (70: 30) as solvent system, few spots were identified. The study helps in the correct identification of the plant. The presence of alkaloids and flavanoids explains that the plant must have valuable medicinal properties which must be explored.
FORMULATION AND CHARACTERIZATION OF ORGANIC- INORGANIC HYBRID FILM FOR TRANSDERMAL DRUG DELIVERY Taksande, Jayshree Brijesh; Gupta, Mona; Trivedi, R V; Wadher, K J; Umekar, M J
Journal of Applied Pharmaceutical Research Vol 4 No 3 (2016)
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Abstract

A novel organic–inorganic hybrid film-forming gel for transdermal application was developed by poly vinyl alcohol using Di methyl polysiloxane as an inorganic-modifying agent, poly N-vinyl pyrrolidone as a tackifier and PEG 200 as a plasticizer. The hybrid film-forming gel can be directly applied on the skin forms a thin bioadhesive film with transparent and non- greasy feeling. The mechanical and bioadhesive properties of films produced from the hybrid gels were investigated and the results showed that the incorporation of appropriate Di methyl polysiloxane into the PVA matrix significantly improves the mechanical strength and skin adhesion properties of the resulting film.  In conclusion, the bioadhesive films formed from organic–inorganic hybrid gel holds excellent qualities for application on the skin and may provide a promising formulation for transdermal delivery of drugs, especially when the patient acceptability from an aesthetic perspective of the dosage form is a main consideration.
Simultaneous estimation of pyrantel pamoate, praziquantel & febantel by high performance liquid chromatography using dual wavelength Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

A sensitive, fast, and stability-indicating gradient reverse-phase liquid chromatography method was developed for quantitative simultaneous estimation of Pyrantel pamoate, Praziquantel and Febantel using reverse phase high performance liquid chromatography by  gradient elusion with dual wavelength at  a specified time interval. All three ingredients were well separated with Phenominax Hypersil C18 (ODS) (4.6 X100mm) 3µm column. The various factors affecting different parameters during method development by HPLC was analyzed and standardized.

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