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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 16 Documents
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Search results for , issue "Vol. 12 No. 6 (2024)" : 16 Documents clear
Development of hesperidin solid dispersion for improved solubility and dissolution using mannitol and PVP K30 as carriers Swarup, Pallavi; Agrawal, Gopal Prasad
Journal of Applied Pharmaceutical Research Vol. 12 No. 6 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i6.723

Abstract

Background: Despite its six-hour half-life, Hesperidin, a bioflavonoid with therapeutic benefits, has low water solubility and bioavailability. This limits treatment. This study improved hesperidin solubility and dissolution by making solid dispersions using appropriate carriers. Methodology: Solid dispersions of hesperidin were prepared using two methods: kneading and solvent evaporation. The carriers utilized in the study were polyvinylpyrrolidone K30 (PVP K30) and mannitol. The formulations were evaluated based on various parameters, including yield, solubility, dissolution rate, drug content, and structural analysis using techniques such as X-ray diffraction (XRD), differential scanning calorimetry (DSC), and infrared (IR) spectroscopy. Results: Solid dispersions yielded 81.2% to 97.5% by weight and included 93.7% to 98.4% drug content. Hesperidin's solubility increased 3.72- to 24.05-fold, with a maximum drug release of 64.06% within 30 minutes. Comparatively, formulations with mannitol as the carrier demonstrated higher solubility (24.05 times) and dissolution (54.06%) than those containing PVP K30 (20.16 times and 34.36%). Discussion: Different carriers alter hesperidin solubility and dissolution. Mannitol improved drug release more than PVP K30. XRD and DSC experiments showed hesperidin's crystalline character changed in solid dispersions, possibly explaining its improved dissolving. IR spectroscopy showed physical dispersion because medication and carriers did not interact chemically. Conclusion: The study showed that solid dispersing hesperidin improves its solubility and dissolution. Drug release was greater with mannitol than with PVP K30. Solid dispersion formulations may improve the bioavailability of poorly soluble medicines like hesperidin.
Antidiabetic effects of Semecarpus anacardium leaf extracts in streptozotocin-induced diabetes in rats Vikhe, Sunayana; Sukhadhane, Pradnya; Vikhe, Rahul; Bornare, Snehal L; Dhavane, Shweta S
Journal of Applied Pharmaceutical Research Vol. 12 No. 6 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i6.736

Abstract

Background: A class of metabolic diseases known as diabetes mellitus is typified by persistently high blood sugar levels brought on by malfunctions in the production or function of insulin. Conventional treatments frequently have drawbacks and side effects, prompting interest in alternative treatments such as herbal remedies. Semecarpus anacardium, known for its medicinal properties, was investigated for its antidiabetic potential. Methods: Semecarpus anacardium leaves were collected, authenticated, and extracted using various solvents. The ethanol extract was subjected to preliminary phytochemical screening, HPLC-DAD analysis, and tested for antidiabetic activity in streptozotocin-induced diabetic rats. Biochemical parameters, histopathological studies, and lipid profiles were analyzed over a 20-day period. Results: The ethanol extract exhibited the highest yield (13.53% w/w) and contained significant amounts of bioactive compounds, including flavonoids and alkaloids. In diabetic rats, the ethanol extract at 200 mg/kg significantly reduced blood glucose levels from 333.35 ± 5.2 mg/dL to 121.68 ± 7.56 mg/dL. Highly significant results were obtained in lipid profiles, with total cholesterol reducing from 176.82 ± 1.07 mg/dL to 103.69 ± 2.85 mg/dL and triglycerides from 188 ± 5.73 mg/dL to 97.17 ± 8.41 mg/dL. Histopathological analysis showed partial restoration of pancreatic islets and reduced fibrosis, indicating the protective effects of the extract. Conclusion: The ethanol extract of Semecarpus anacardium leaves demonstrates significant antidiabetic and lipid-lowering effects in streptozotocin-induced diabetic rats. These findings support the potential of this plant as a natural therapeutic agent for diabetes management, warranting further research for clinical application.
In vitro evaluation of Punica granatum fruit peel extract for its potential anti-diabetic effects More, Rutuja K; Pingale, Prashant L; Upasani, Chandrashekhar D; Amrutkar, Sunil V
Journal of Applied Pharmaceutical Research Vol. 12 No. 6 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i6.739

Abstract

Background: With growing awareness of pomegranate's health benefits, pomegranate products have been consumed more frequently in recent years, and pomegranate peel has emerged as one of the most prevalent wastes in the food industry. Pomegranate Peel concentrate is an indigenous substance with strong antioxidant and antidiabetic actions as a result of its tannins as well as polyphenols content. Methods: In the present study, pomegranate skin extract, both liquid and alcohol-based, was evaluated for polyphenolic and flavonoid content. Alcoholic fruit peel extract was also assessed for 1,4-α-D-glucan glucanohydrolase and α-D-glucoside glucohydrolase enzyme activity. Results: According to findings, pomegranate peel extract showed significant antioxidant content. Phytochemical analysis of ethanol-derived extract of pomegranate peel found a noteworthy amount of ellagitannins and flavonoids such as Punicalin, Punicalgin, Punicic acid, Catechin, Quercetin, Rutin, and Kaempferol. In contrast, punicalgin, ellagic acid, and gallic acid are responsible for antidiabetic activity. The LC-MS characterization of peel extract of pomegranate showed 10 bioactive compounds. The IC50 value for 80% alcoholic extract of pomegranate peel was found to be 5.86 mg/ml of α- amylase and 6.58 mg/ml of α-glucosidase. Conclusion: It was found that the inhibition of 1,4-α-D-glucan glucanohydrolase and α-D-glucoside glucohydrolase enzymes could be an effective mechanism by which it can give anti-diabetic effects.
Phytochemistry and pharmacological potential of aloscasia macrorrhiza: A comprehensive review Chakraborty, Amitesh; Giri, Santanu; Shah, Aditya Dev; Adhikari, Tushar
Journal of Applied Pharmaceutical Research Vol. 12 No. 6 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i6.742

Abstract

Background: Aloscasia macrorrhiza, commonly known as Giant Taro, is a species rich in phytochemicals with diverse pharmacological properties. Phytochemical analysis shows different bioactive compounds like alkaloids, flavonoids, terpenoids, phenolics, and saponins in different components of the plant body, including leaves, stems, and roots. Alocasin, a class of alkaloids, is most prominent in this plant. These substances are likely responsible for different biological activities, as Aloscasia macrorrhiza shows. Aim: This review unveils the phytochemical composition and pharmacological activities of various parts of Aloscasia macrorrhiza. Method: Multiple Literature, including research and review papers, were searched for based on their title, abstracts, and keywords. Keywords like ‘Aloscasia macrorrhiza,’ ‘Phytochemistry,’ ‘Traditional uses,’ and ‘Ethnomedicinal uses’ were used to collect information. Abstracts of articles with relevant titles were screened, and the full text was considered. Only articles published from 2018 to 2024 were considered. Based on their classes and mechanistic actions, this review consolidated these phytoconstituents. Results: These phytoconstituents exhibit a wide array of therapeutic activities, including anti-inflammatory (due to tannins and polyphenols), antimicrobial (due to terpenes and lectins), antioxidant (due to polyphenols), anticancer (due to flavonoids), anti-diabetic (due to flavonoids) effects. Conclusion: This review provides insights to the therapeutic potential of Aloscasia macrorrhiza and hence forms a bridge of understanding between the traditional uses and the modern Pharmacology studies. In the future, further clarification and detailed mechanistic insight can be done. Aloscasia macrorrhiza may have potential therapeutic applications and is subject to further investigation.
Isolation, purification, and characterization of bioactive peptide from Chenopodium quinoa seeds: therapeutic and functional insights Sen, Amit; Sharma, Gunjan; Tomer, Nalini; Shibu B., Sahaya; Moin, Sarmad
Journal of Applied Pharmaceutical Research Vol. 12 No. 6 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i6.835

Abstract

Background: Chenopodium quinoa is a nutrient-dense pseudocereal packed with proteins, vital amino acids, and bioactive substances that may have medicinal uses. These include antioxidant, anti-inflammatory, anti-cancer, and antibacterial properties. Notably, quinoa proteins and peptides show multifunctional bioactivities such as immunological regulation, cancer cell death, and microbial suppression. This study aimed to separate, purify, and describe the bioactive proteins found in quinoa seeds, emphasizing their potential applications as medicines. Methodology: Quinoa seeds underwent protein extraction, defatting, and de-saponification. Ion exchange chromatography, dialysis, and ammonium sulfate precipitation were used to purify the seeds. The Lowry technique was used to quantify the proteins. Functional tests assessed the seeds' antibacterial, antifungal, protease, and anticancer properties, and peptide identification was carried out using LC-MS/MS. Results: The protein content decreased during purification steps, indicating effective removal of impurities. Protein fractions exhibited significant antibacterial and antifungal activities. Protease activity varied among fractions, with the pH 2 fraction showing the highest activity. Crude extract and pH 2-treated fractions demonstrated significant anticancer activity against A549 and Hela cell lines. pH 2 fraction exhibits the highest protease activity of 2.451 units/ml, indicating enhanced enzymatic capability under acidic conditions. Peptides identified from the pH 2 fraction showed potential therapeutic properties. Conclusion: The antibacterial, antifungal, proteolytic, and anticancer properties of quinoa-derived peptides and proteins demonstrate their potential for use in medicine. Clinical validation and the creation of functional foods or nutraceuticals based on quinoa should be the main objectives of future research.
Expose the bioactive properties of Picrorhiza kurroa root extract oil (PKEO): phytochemical composition and therapeutic activities Patil, Amol R.; Maru, Avish D.
Journal of Applied Pharmaceutical Research Vol. 12 No. 6 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i6.841

Abstract

Background: The present study aims to explore the bioactive properties of essential Oil (PKEO) derived from Picrorhiza kurroa (commonly known as kutki), a medicinal plant known for its therapeutic potential. Picrorhiza kurroa essential oil has a distinct chemical profile, which sets it apart from other essential oils. The bioactive compounds present in Picrorhiza kurroa essential oil may lead to the development of new drugs, particularly for treating inflammatory and oxidative stress-related disorders. The research aims to study the extraction, phytochemical composition, and various biological activities of PKEO. Methodology: Oil obtained through hydro-distillation contains various phytochemical compounds, including steroids, triterpenoids, alkaloids, phenols, proteins, flavonoids, and tannins. Its bioactivity and aroma are attributed to its phenolic and sesquiterpene esters. Results and Discussion:  The total phenolic content is 250.47 μg GAE/g, and the total flavonoid content is 245.26 μg QE/g. UV-visible and IR spectroscopic analyses confirm the presence of phenolic and terpenoid ester functional groups. PKEO has moderate antioxidant activity, with IC50 values of 98.19 µg/mL in DPPH scavenging and 42.72% inhibition in the ABTS assay. It also exhibits dose-dependent inhibition of protein denaturation and HRBC stabilizing activity. Antimicrobial tests show PKEO inhibits E. coli growth, indicating potential antibacterial properties. Conclusion: These findings highlight PKEO's promising bioactive profile, suggesting potential therapeutic and cosmetic formulation applications. The antifungal activity also shows the potential antifungal effects of the PKEO.

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