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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 22 Documents
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Search results for , issue "Vol. 13 No. 3 (2025)" : 22 Documents clear
Phytochemical analysis, antioxidant potential, and cytotoxic activity of extracts of Quisqualis indica L. Verma, Ajay; AKS Rawat
Journal of Applied Pharmaceutical Research Vol. 13 No. 3 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i3.1215

Abstract

Background: The present study investigates the antioxidant and cytotoxic potential of the 50% hydroalcoholic extract of Quisqualis indica leaves. Methodology: Phytochemical screening was conducted to determine the presence of phenolics and flavonoids. TPC and TFC were analyzed using the Folin–Ciocalteu method and the aluminum chloride colorimetric assay, respectively. The antioxidant activity was evaluated through the DPPH radical scavenging assay at concentrations ranging from 10 to 100 µg/mL. Cytotoxicity was assessed in A549 human lung carcinoma cells using the MTT assay with extract concentrations from 0 to 1000 µg/mL. Results and Discussion: Phytochemical analysis confirmed the presence of phenolics and flavonoids, with total phenolic content measured as 9.25 ± 0.081 mg gallic acid equivalents (GAE)/g 50% hydroalcoholic extract and total flavonoid content as 4.33 ± 0.24 mg quercetin equivalents (QE)/g 50% hydroalcoholic extract. Antioxidant activity was assessed using the DPPH radical scavenging assay across extract concentrations ranging from 10 to 100 μg/mL. The 50% hydroalcoholic extract exhibited a dose-dependent antioxidant effect with an IC50 value of 48.56 μg/mL. Cytotoxicity was evaluated against A549 human lung carcinoma cells using the MTT assay, with treatments administered at concentrations ranging from 0 to 1000 μg/mL. The extract demonstrated significant cytotoxicity with an IC50 value of 4.76 μg/mL. Conclusion: These findings suggest that Q. indica may serve as a potential source of bioactive compounds with antioxidant and anticancer activities, warranting further investigation through in vivo and mechanistic studies.
Phytochemical profiling and antioxidant assessment of Cassia auriculata leaves via GC-MS Ranaware, Abhishek M; Nalawade, Savita P.
Journal of Applied Pharmaceutical Research Vol. 13 No. 3 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i3.1247

Abstract

Background: This research aimed to investigate the phytochemical composition, quantify key bioactive compounds such as phenolics and flavonoids, analyze the secondary metabolite profile using GC-MS on methanolic leaf extracts, and evaluate the antioxidant capacity via the DPPH assay. Methodology: The Soxhlet extraction method is employed to obtain crude extracts of Cassia auriculata using solvents including ethanol, methanol, chloroform, and water. These extracts undertook qualitative analysis to detect various bioactive phytochemicals. The total phenolic and flavonoid concentrations were quantified. The methanolic leaf extract underwent phytochemical analysis using a gas chromatography-mass spectrometry (GC-MS) device, following established procedures. The antioxidant capacity of the methanolic leaf extracts was assessed by determining their ability to scavenge free radicals of 2,2-diphenyl-1-picrylhydrazyl. Results and Discussion: Initial phytochemical screening revealed the presence of various secondary metabolite groups. Out of all the solvent extracts assessed, the methanolic extract displayed the highest concentrations of phenolic and flavonoid compounds, measuring 9.48 ± 0.06 mg of Gallic acid equivalents per gram of extract and 6.56 ± 0.03 mg of Quercetin equivalents per gram of extract, respectively. GC-MS analysis of the methanolic extract identified 28 bioactive compounds with known pharmacological significance. Conclusion: The antioxidant activity, evaluated using the DPPH radical scavenging assay, demonstrated that the methanolic extract had the most potent radical scavenging effect among the extracts tested (IC50-48.96 µg/ml). These findings suggest that Cassia auriculata leaves extract is a promising source of natural antioxidants and bioactive compounds, supporting its traditional use in herbal medicine.

Page 3 of 3 | Total Record : 22

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