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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 2 Documents
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Search results for , issue "Vol. 4 No. 1 (2016)" : 2 Documents clear
Dendrimers: novel carriers for drug delivery Chaudhari, H. S.; Popat, R. R.; Adhao, V. S.; Shrikhande, V. N.
Journal of Applied Pharmaceutical Research Vol. 4 No. 1 (2016)
Publisher : Creative Pharma Assent

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Abstract

Dendrimers are highly branched, organic compounds with well-defined, symmetrical structure. From chemical point of view they are three-dimensional polymers, characterized by a globular shape. At the end of the arms are terminals, functional groups, which can be easily modified in order to change their chemical and physical properties. Dendrimers have nanoscopic particle size range from 1 to 100 nm. They are ideal drug delivery systems due to their feasible topology, functionality and dimensions, their size is very close to various important biological polymers and assemblies such as DNA and proteins. The structure of dendrimer molecules begins with a central atom or group of atoms labeled as the “core.” From this central structure, branches of other atoms called ‘dendrons.’ The continuous branching results in layers of branch structure called “generations.”Synthesis of dendrimers done by four methods. These are ‘Divergent’ Dendrimer Growth , ‘Convergent’ Dendrimer Growth ,‘Double Exponential’ and ‘Mixed’ Growth ,‘Click’ Synthesis (Hypercores and branched monomers growth). Mechanisms of drug loading onto dendrimer carriers by physical encapsulation of drug molecules and chemical conjugation of drug molecules. The conjugates show increased solubility, decreased systemic toxicity and selective accumulation in solid tumors. Various applications as pharmaceutical and non pharmaceuticals. Dendrimers may have toxicity mainly attributed to the interaction of the cationic dendrimers surface with negative biological load membranes damaging cellular membranes causing hemolytic toxicity and cytotoxicity also limitation that does not apply where the drug is solubilised with dendrimer and then released in the gut for absorption. Some Marketed products of dendrimers are available named as Starburst, Priostar, Stratus CS, Vivagel, Alert ticket, SuperFect, Taxotere.
An overview of tuberculosis chemotherapy – a literature review Sarangi, Manoj Kumar; padhi, Sasmit
Journal of Applied Pharmaceutical Research Vol. 4 No. 1 (2016)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.268 KB)

Abstract

Tuberculosis (TB) is a major global health threat. The emergence of human immunodeficiency virus (HIV) and also multi drug resistant (MDR) and extremely drug resistant (XDR)-TB poses a vital challenge to the control of the disease. For the last 50 years, no new anti-TB drug has been discovered. This literature review provides a brief discussion of existing drugs and emerging drug targets, and also of the advantages of incorporating modern drug delivery systems and immune modulators in order to improve the existing treatment regimen in terms of better efficacy, reduced drug administration frequency, shortened period of treatment and reduced drug related toxicity. The investigation for a new drug target is essential to continue the battle against MDR and XDR-TB. However, owing to the enormous cost and time involved in new drug development, improvement of the existing treatment regimen is seen to be a valid alternative.

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