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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 3 Documents
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Search results for , issue "Vol. 4 No. 4 (2016)" : 3 Documents clear
Synthesis and antifungal activity screening of some novel 7–substituted –2–hydroxy–quinoline schiff bases Kumar, M. R. Pradeep
Journal of Applied Pharmaceutical Research Vol. 4 No. 4 (2016)
Publisher : Creative Pharma Assent

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Abstract

With an objective of synthesizing some novel, potent and broad spectrum antifungal activity having compounds, here some novel quinoline derivatives are reported. Initially 7-substituted-2-cholro-3-formylquinolines were prepared using well known Vilsemeir-Hack reagent method. These on microwave irradiation with 4M HCl yielded 7-substituted-2-hydroxy quinoline-3-carbaldehydes I(a, b), which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline II(a-f). The structure of all newly synthesized compounds was confirmed by spectral study such as IR, 1H NMR, 13C NMR and mass spectroscopy. All the synthesized compounds were screened for in-vitro antifungal activity by two fold serial dilution method using fluconazole as the standard drug. Compounds II a, II b and II d showed significant antioxidant activity
Concept of “ama dosha” WSR to free radicals Kumar, Munish; Kumar, Parvesh
Journal of Applied Pharmaceutical Research Vol. 4 No. 4 (2016)
Publisher : Creative Pharma Assent

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Abstract

Ama is considered as root cause of all diseases in the body. It has tremendous capacity to vitiate the Doshas and disturbing the homeostasis (Dhatusamya). Ama is the result of improper digestion or partially digestion of the food particle due to hypo function of Jatharagni and also due to accumulation of mala in the body. In modern physiology, Ama can be correlated with deadly Free radicals. Free radicals are atoms, ions or molecules that contain one or more unpaired electron, which requires neutralization by free radical scavengers. The majority of free radicals that damage biological systems are oxygen free radicals, and these are known as “Reactive oxygen species”. Thus it exists in incomplete metabolic state which is also the state of Ama described as Avipakam (incompletely metabolized). This Ama is responsible for the production of various diseases. In the same way, free radicals are also found to be root cause of many diseases. The aim of present article is to understand the concept of Ama as well as free radicals as a root cause of diseases and its treatment.
Ligand conjugated liposomal drug delivery system for enhanced brain uptake of ampicillin Lala, R.; Nandvikar, N.; Agnihotri, S.
Journal of Applied Pharmaceutical Research Vol. 4 No. 4 (2016)
Publisher : Creative Pharma Assent

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Abstract

Targeting of antimicrobial agents by means of liposomes may be of great value in the treatment of intra or extracellular infections compare to conventional forms of antimicrobial therapy. In the present study Ampicillin loaded non-targeted Polyethylene glycolated liposomes and targeted Glutathione Polyethylene glycollated liposomes of about 132.14 nm size were prepared with 80 % of drug entrapment. Prepared liposomes were evaluated for in vitro, in vivo release profile and brain uptake studies. Results of these studies revealed more absorption of drug than standard Ampicillin solution and non targeted liposomes (Auc0-6h 1858.908 µg h/ml) and 3.5 times increase in brain uptake. Incorporation of polyethylene glycol in the liposomes increased the drug concentration and circulation time in plasma as well as in the extracellular fluid of brain thus improved therapeutic availability of Ampicillin trihydrate.

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