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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol. 5 No. 2 (2017)" : 6 Documents clear
Development and validation of RP HPLC method for determination of metformin and sitagliptin in bulk and pharmaceutical dosage form D., Kavitha; Sahoo, S K; P., Venkateswara Rao; M., Nagamani; Ch., Bhagyalaxmi
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

A simple and rapid reversed phase-high performance liquid chromatographic method was developed for simultaneous determination of Metformin and Sitagliptin in Tablet Dosage form. The elution was done with a mobile phase of Water: Methanol (60:40) on Intersil-BDS C18 column (250 × 4.6 mm, 5 μm particle size). The wavelength detector was set at 258 nm. Retention times for Metformin and Sitagliptin were around 2.869 min, 3.942 min respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated according to the respect of linearity, ranges, precision, accuracy, repeatability, reproducibility, detection and quantification limits. Linear ranges were established between 20-80 μg/mL for both the drug. The LOD and LOQ for Metformin were found to be 0.663, 1.92 and for Sitagliptin were found to be 0.405, 1.228 respectively. The described High Performance Liquid Chromatography method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form
Chemometric – assisted UV spectrophotometric method for determination of antihyperlipidemic agents in pharmaceutical formulation Gandhi, Santosh V; Mutha, Amit S
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

This presented work is based on application of two multivariate calibration methods for simultaneous UV-VIS spectrophotometric determination of active substances in combined pharmaceutical formulation composed of Atorvastatin calcium (ATV) and Ezetimibe (EZT). The methods used were Principal Component Regression (PCR) and Partial Least Square (PLS). The Spectra of ATV and EZT were recorded at concentrations within their linear range 5.0-30.0 μg/ml for both drugs. 28 set of mixtures were used for calibration and 08 set of mixtures were used for validation in the wavelength range of 230 to 260 nm with the wavelength intervals λ= 0.5 nm in methanol. The methods were validated as per International Conference on HarmonizationQ2 (R1) (ICH) guidelines. These methods were successfully applied for determination of drugs in pharmaceutical formulation (tablet) with no interference of the excipient as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control as well as in process control of drugs and formulation.
Liposomes in dermatological diseases Kamra, M.; Diwan, A
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

Liposomes are vesicles comprising of spherical phospholipids making them useful for topical applications of drugs. Liposome research has been expanded considerably and nowadays, it is possible to construct a wide range of liposomes varying in size, phospholipids composition and surface characteristics. In dermatological diseases, the topical application of liposomes has proven to be of high therapeutic value. Liposomes can be used as carriers for hydrophilic as well as lipophilic therapeutic agents because of their amphipathic character. They may improve stabilization of instable drugs by encapsulating them. They have the potential to target drugs into the pilosebaceous structures and hence have an advantage for treatment of hair follicle-associated disorders. Liposomal encapsulated drugs are found useful in the treatment of acne, atopic dermatitis, psoriasis, vitiligo, superficial vein thrombosis and hair removal etc
Smart ungual biopenetrant from the roots of Beta vulgaris Madhav, N. V. Satheesh; Singh, Kirti
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

The main objective of the current research was to isolate biopenetrant from Beta vulgaris and formulate bioadhesive layers loaded with terbinafine using this biopenetrant for delivery through nail. Form the preparation of films, Rosa centifolia and Vitis vinifera were used as a biopolymer. Beta vulgaris was used as biopenetrant. The formulations prepared using Beta vulgaris biopenetrant were compared with formulations containing papain as standard penetrant. Four bio-adhesive films of different ratios were prepared by film casting method using each penetrant. The formulated films were evaluated for various parameters like weight, thickness, nail adhesivity, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation LB4 (containing 1:4 Beta vulgaris biopenetrant) was found to be the best formulation having R2 value 0.990 with zero order as best fit model. The results obtained conclude that biopenetrants can be used as natural penetration enhancers
A review on mouth dissolving tablet Patil, H. K.; Patil, G M; Jain, V H; Tadvi, S. A.; Pawar, S. P.
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

The demand for MDT (Mouth Disintegrating Tablet) has been increasing from the last decade particularly in geriatric, pediatric and patient with some sort of disabilities in swallowing. MDTs are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopoeia adopted the term Orodispersible tablet for MDTs. Mouth disintegrating tablets are also known as Fast melting tablets, Orodispersible tablets, fast dissolving/dispersing tablets or melt in mouth tablets. This article reviews the potential benefits offered by MDTs as an oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Desired characteristics and challenges for developing fast disintegrating drug delivery systems, quality control tests, various techniques used in the preparation of fast disintegrating drug delivery systems like lyophilization technologies, tablet molding method, sublimation techniques, spray drying techniques, mass extrusion technology, direct compression method and uses of super-disintegrates. It also reviews the patented technologies for fast dissolving tablets, advantages and disadvantages of different technologies for preparing fast disintegrating dosage form, future prospective for MDTs. The growing importance for MDTs is due to the potential advantages offered by this technology. MDT is a New Drug Delivery system with least disintegration time and ease of self administration
Bioanalytical method development and validation of bleomycin sulphate Prashar, Yash; Rana, Harkaran Singh; Bais, Souravh
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

Bleomycin is an anti-neoplastic drug that has recently been used for the treatment of vascular anomalies. An expedient method was developed for the determination of plasma bleomycin levels using ion-paired reversed phase high performance liquid chromatography (HPLC). The concentration was found to be proportional to the area and the response of the detector was determined to be linear over the range of 1-6 µg/ml for both Bleomycin A1 and Bleomycin B2. Recovery was approximately 100%. This method provides a simple and rapid way of determining the levels of bleomycin A2 and B2 in human and rat plasma

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