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Smart Medical Journal

SMedJour
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Published by Universitas Sebelas Maret

ISSN : 26211408 EISSN : 26210916 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Smart Medical Journal (SmedJour) is published by Faculty of Medicine Universitas Sebelas Maret. SMedJour publishes original research articles or article review in the basic medical sciences, clinic medical sciences, medical education and public health.

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Articles 6 Documents

Search results for , issue "Vol 1, No 1 (2018): Smart Medical Journal" : 6 Documents clear

Tahu yang Difermentasi Rhizopus sp. Menurunkan Kadar Glukosa Darah Tikus Putih(Rattus norvegicus) Eldaa Putik Bunga Melati; Budiyanti Wiboworini; Briandani Subariyanti
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introductions : Controlling of blood glucose would be important to prevent many complications of DM. Consuming fiber is one way to maintain blood glucose level. These amount of fiber could be obtained in tofu fermented by Rhizopus sp. This research aimed to know the effect of tofu fermented by Rhizopus sp. in controlling blood glucose level of diabetic induced white rats (Rattus norvegicus).Methods : This research was a laboratoric-experimental study. The subjects were Rattus norvegicusgrouped randomly. The total 30 Rattus norvegicus were injected by Alloxan 15mg/100gramBW, then randomly allocated into 5 group, positive control group (glibenclamide 0.05mg/100gramBW/day), negative control group (aquadest), and treatment groups with different doses of fermented tofu (0.025gram/100 gramBW/day; 0.050gram/100 gramBW/day; 0.100gram/100gramBW/day). The research design was Pretest and Posttest Control Group Design. The fasting blood glucose were measuredbefore Alloxan injection (day-2), after Alloxan injection (day-5), and after the treatments (day-19).Results : there was a significant decrease of blood glucose level in all treatment groups and positive control (p = 0.001). Post Hoc Test showed a significant difference between all treatment groups and positive control group compared to negative control group (p = 0.001).Conclusion :Tofu fermented by Rhizopus sp. was able to decrease blood glucose level in diabetic rats (Rattus norvegicus). Keyword : Tofu fermented, Rhizopus sp., blood glucose level, alloxan, glibenclamide

Kepekaan terhadap Humor berhubungan dengan Tingkat Kecemasan Mahasiswa Fakultas Kedokteran Saat Menghadapi Ujian Muhammad Yusuf Karim; Suyatmi Suyatmi; Zulaika Nur Afifah
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Background:Medical students are facing examination in each topics to evaluate learning achievement. An examination could be a trigger for anxiety. Uncontrolled anxiety could affect the learning achievement. Coping mechanism is needed to decrease the anxiety level. One of the coping mechanisms to decrease anxiety level is sense of humor. The aim of this study was to evaluate whether sense of humor could affect the anxiety level.Methods:This was an observational analytic with cross-sectional design study.The subjects were First Year Medical Students of Universitas Sebelas Maret. The sample was collected by simple random sampling method. Sense of Humor was assesed using Multidimensional Sense of Humor Scale (MSHS). Anxiety level was assesed using Taylor Manifest Anxiety Scale (TMAS). Collected data was analyzed with Kolmogorov-Smirnov Normality Test and Pearson Correlation Test.Results: There were 152 samples in this study. The mean of sense of humor and anxiety level were 69.90 ± 7.22 and 22.16 ± 6.93 respectively. The majority of the samples showed that 78.3% had a high sense of humor, while 21.7% had a moderate sense of humor. More than half of the samples (50.7%) were anxious and 49.3% were not anxious. The result of the Pearson correlation test showed r= -0.263 and p= 0.001.Conclusions:This study indicates a negative correlation between sense of humor and anxiety level towards examination on First Year Medical Student of Universitas Sebelas Maret. Keywords: sense of humor, anxiety level, examination

Hubungan antara Tingkat Pengetahuan dan Sikap dengan Tindakan Pencegahan Penyakit Rabies pada Warga di Wilayah Puskesmas Kuta II Ni Kadek Ayu Septiani Sarjana; Arsita Eka Prasetyawati; Dyah Ratna Budiani
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Rabies is a disease of animals (usually vertebrate) which is zoonotic (transmissible to humans). Rabies occurs in 24 out of the 34 provinces of Indonesia. Rabies is caused by a virus in the Family: Rhabdivoridae, Genus: Lyssavirus. Control the dog population and dog vaccination is effective and economical method to prevent the incidences of rabies in humans. This study aims to investigate the relationship between level of knowledge and attitude to the practice in prevention rabies infection in residents lived in area covered by Puskesmas Kuta II.Methods: This study was a cross-sectional study and carried out by simple random sampling of 96 residents in the area of Puskesmas Kuta II. In this study, the independent variables are knowledge of and attitudes towards rabies disease while the dependent variable is the practice to prevent rabies infection in human. Data were collected by a questionnaire-based interview. Analyses were then carried out using the chi-square (x2) followed by multivariate analysis using multiple logistic regressions.Results: This study showed that knowledge has a significant relationship with practice for rabies disease prevention (p = 0.013; OR 4.240; 95% CI 1.352 up to 13.296). Attitude has a significant positive relationship with the value of practice for rabies disease prevention (p = 0.015; OR 3.073; 95% CI 1.233 up to 7.627). The combined effect of knowledge and attitudes to practice for rabies prevention were approximately 20.90% (Negerkerke R square = 0.209).Conclusions: There was a significant relationship between knowledge and attitudes with the practice for rabies disease prevention in residents in the area of Puskesmas Kuta II, the higher level of knowledge and improved attitudes will improve practice for rabies disease prevention amongst residents in the area of Puskesmas Kuta II. Key words: Rabies; Rabies; Preventio; Knowledge; Attitude; Practice

Hubungan Lingkar Pinggang dan Lingkar Panggul dengan Tekanan Darah pada Pasien Program Pengelolaan Penyakit Kronis (Prolanis) Sumardiyono Sumardiyono; Eti Poncorini Pamungkasari; Anton Giri Mahendra; Oki Saraswati Utomo; Devita Mahajana; Wakhid Ryan Cahyadi; Mila Ulfia
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Obesity is a state of excessive accumulation of fat in the body, which is a risk factor for cardiovascular disease. Obesity can be measured using anthropometric methods measuring waist circumference and hip circumference. This study aims to find the relationship between the size of waist circumference and hip circumference to blood pressure in prolanis participants in the working area of Kedawung I Public Health Center, Sragen Regency.Method: This study was an observational analytic study using a cross sectional design. The subjects were prolanis participant patient with a history of hypertension in the Kedawung I Community Health Center in Sragen in July 2017. Sampling was done by simple random sampling. The number of subject were 60 persons.Results: There were significant relationship between waist circumference and systolic/ diastolic blood pressure with weak strength (r = 0.304; p = 0.018 and r = 0.337; p = 0.008) and significant relationship between hip circumference with systolic/diastolic blood pressure with weak strength (r = 0.263; p = 0.042 and r = 0.306; p = 0.017).Conclusion: the increasing size of waist and hip circumference may increase blood pressure in prolanis participants.

Potensi Scopoletin sebagai Agonis Reseptor Transferin 2 untuk Pengembangan Terapi Anemia Defisiensi Besi Asti Swari Paramanindita; Dono Indarto; Balgis Balgis
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Iron Deficiency Anemia (IDA) is caused by imbalance between iron intake and iron loss in blood circulation. Increased hepcidin level plays an important role in the etiology of IDA. Normally, expression of hepcidin protein is controlled by three different pathways, one of them is interaction between holo Transferin (Holo-Tf) and Transferrin Receptor 2 (TfR-2). Recently, Indonesian herbal plants have widely been used as herbal medicine but there is no active compound that can activate TfR-2 for IDA therapy. The aim of this study was to explore phytochemicals derived from Indonesian herbal plants to interact with TfR-2.Methods: The study was a bioinformatics study with a molecular docking method. The SWISS-MODEL software was used to make TfR-2 protein modeling because the molecular structure of TfR-2 remains unknown. Holo-Tf was used as a standard ligand and obtained from Protein Data Bank with PDB ID 1SUV. All Indonesian phytochemicals which (1) registered at HerbalDB (2) had a three-dimensional molecular structure at PubChem (3) met Lipinski’s Rule of Five criteria were used in this study. AutoDock Vina 1.1.2 was used to analyze the binding affinity which was in kcal/mol. Phytochemical-TfR-2 binding complexes were visualized by using Chimera 1.10rc and or Pymol 1.7.Result: The docking scores of holo-Tf modification with TfR-2 were -6,4±0,1 kcal/mol at Arg466 and -3,4±0,1 kcal/mol at Arg689 respectively. Interaction of modification holo-Tf and TfR-2 was observed not only at Arg466 and Arg689 but also with Asp642 and Ile682. Docking scores of scopoletin were -7,1±0,1 kcal/mol at Arg466 and -5,4±0,1 kcal/mol at Arg689. Scopoletin could interact with TfR-2 at Arg466, Arg689, and Leu630 residues.Conclusions: Computationally, scopoletin is a potential TfR-2 agonist. In future studies, in vitro assay will be used to evaluate the agonist effect of scopoletin in TfR-2.

Korelasi Panjang Tulang Tibia Terhadap Tinggi Badan Pada Mahasiswa FK UMSU Putra Diandro Utama Ritonga; Hendra Sutysna
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Estimation of body height is one of the important parameter in the anthropology forensic, which the body height became the first action in identification. The regression formula using the tibia length, sex, and age might have valid approximation for body height which helpful in clinical context. Methods: The analytic descriptive researchwith the cross-sectional design was done on 112 subject consist of male and female satisfy inclusion and exclusion criteria. Sample was selected by total sampling technique.Results: Tibia length resulting correlation ranging between 0,488 and 0,968 (p<0,001). The linear regression formula showed Standard Error of the Estimate (SEE) ranging between 0,810 and 3,495 (p<0,001). Conclusion: A significant correlation between tibia length and body heightwas found with a strong correlation. Hence, a linear regression formula was derived for the estimation of body height from tibia length.Keywords: tibia length; body height; regression formula; anthropometry

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Abstract

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Abstract

Contact Name
Nanang Wiyono

Contact Email
smjfkuns@gmail.com

Phone
-

Journal Mail Official
smjfkuns@gmail.com

Editorial Address
-

Location
Kota surakarta,

Jawa tengah

INDONESIA