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ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 3 Documents
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Search results for , issue "Vol 17, No 1 (2021): Maret" : 3 Documents clear
Studi In Silico Senyawa 1,4-Naphthalenedione-2-Ethyl-3-Hydroxy sebagai Antiinflamasi dan Antikanker Payudara Richa Mardianingrum; Kamiel Roesman Bachtiar; Susanti Susanti; Aas Nuraisah Aas Nuraisah; Ruswanto Ruswanto
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): Maret
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.43979.83-95

Abstract

Inflamasi merupakan suatu respon dari tubuh terhadap adanya cedera maupun infeksi yang ditandai dengan timbulnya kemerahan, demam, bengkak, nyeri dan hilangnya fungsi. Inflamasi berkontribusi terhadap ketidakseimbangan sekresi sitokin yang akan menghambat terjadinya apoptosis pada sel kanker sehingga menyebabkan hiperproliferasi sel. Kanker payudara merupakan salah satu penyakit kanker dengan prevalensi tertinggi di urutan ke dua di dunia. Penelitian terdahulu melaporkan pemberian minyak atsiri rimpang bangle (Zingiber purpureum Roxb.) secara topikal mampu memberikan penghambatan inflamasi yang lebih tinggi daripada triamcinolone, namun spesifik senyawa yang berpotensinya belum diketahui. Tujuan dari penelitian ini, yakni mencari senyawa aktif hasil analisis GCMS minyak atsiri rimpang bangle yang berpotensi sebagai antiinflamasi dan antikanker payudara secara in silico. Metode yang digunakan berupa screening Lipinski’s rule of Five, farmakokinetika dan toksisitas senyawa hasil analisis GC-MS, serta penambatan molekul dan dinamika molekular. Hasil screening dan simulasi penambatan molekul menunjukkan bahwa senyawa 1,4-naphthalenedione-2-ethyl-3-hydroxy dapat berikatan dengan reseptor COX-1 (antiinflamasi), dan hERα (antikanker payudara), namun lebih selektif terhadap reseptor COX-1 dengan nilai energi bebas (ΔG) yang lebih kecil yakni sebesar -7,20 kkal/mol, dibandingkan dengan interaksinya terhadap reseptor Erα yang bernilai -6,00 kkal/mol. Hasil simulasi dinamika molekular menggunakan metode kalkulasi MM-GBSA menunjukkan bahwa kompleks (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(COX-1) memiliki nilai ∆GTOTAL sebesar -24,22 kkal/mol. Nilai ini lebih kecil dibandingkan dengan ∆GTOTAL kompleks (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(hErα) sebesar -8,92 kkal/mol). Hal ini menunjukkan bahwa tingkat afinitas 1,4-naphthalenedione-2-ethyl-3-hydroxy terhadap COX-1 diprediksi lebih baik dan lebih poten sebagai antiinflamasi dibandingkan sebagai antikanker payudara.In Silico Study of 1,4-Naphthalenedione-2-Ethyl-3-Hydroxy Compounds as Anti-inflamation dan Breast Anticancer. Inflammation is a response from the body to injury or infection which is characterized by redness, fever, swelling, pain, and loss of function. Inflammation contributes to the imbalance of cytokine secretion which will inhibit apoptosis in cancer cells, causing cell hyperproliferation. Breast cancer is one of the cancer diseases with the second-highest prevalence in the world. The pioneering works reported that topical application of Bangle (Zingiber purpureum R) was able to provide a higher inhibition of inflammation than triamcinolone, however, the specific potential of the compound was unknown. The purpose of this study is to find active compounds that have the potential to be anti-inflammatory and anti-cancer in the breast using in silico approach. The methods used are screening Lipinski’s Rule of Five, pharmacokinetics and toxicity of compounds from GC-MS analysis and molecular docking, and molecular dynamics. The screening and molecular docking simulation results showed that the compound 1,4-naphthalenedione-2-ethyl-3-hydroxy can bind to COX-1 (anti-inflammatory), and ERα (Estrogen Reseptor α), but was more selective towards COX-1 receptor with a binding affinity (ΔG) -7.20 kcal/mol, compare to its interaction with ERα which is -6.00 kcal/mol. The results of molecular dynamics simulation using the MM-GBSA calculation method show that the complex (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(COX-1) has a value of ∆GTOTAL of -24.22 kcal/mol). This value is smaller than ∆GTOTAL of the complex (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(hErα) of -8.92 kcal/mol. The results indicate that the affinity level of 1,4-naphthalenedione-2-ethyl-3-hydroxy to COX-1 was predicted to be better and more potent as an anti-inflammatory than as an anti-breast cancer.
Optimization of the Proportion of Surfactant, Co-Surfactant, and Candlenut Oil for Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Secang Heartwood (Caesalpinia sappan L.) Methanolic Extract Anif Nur Artanti; Fea Prihapsara; Nugraha Mas'ud; Dian Eka Ermawati
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): Maret
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.39054.124-131

Abstract

This study aimed to determine the optimum proportion of hazelnut oil, surfactants, and cosurfactants for SNEDDS of Secang Heartwood using the simplex lattice design (SLD) method using the Design-Expert software. The SNEDDS formula was prepared using Tween 80 and Croduret 50 ss as surfactants, propylene glycol as cosurfactant, and candlenut oil based on physical stability parameters: formula transmittance (%), separation phase, and emulsification time. The optimum SNEDDS formula was compared with the predictive value [p> 0.05] provided by the SLD; then extract the loading dose, accelerated stability test, analysis of particle size, and zeta potential. The optimum proportion of Tween 80-Croduret 50 ss, propylene glycol, and hazelnut oil, based on the SLD, was 62.43%; 22.57%; and 15.0%. The results showed that the transmittance was 93.2%; emulsification time was 74.67 seconds, and; separation phase was 0.89. The SLD's predictive values of the transmittance percentage, emulsification time, and separation phase were 94.98%, 78.97 seconds, 0.84, respectively. The results of the one-sample t-test statistical analysis showed no significant difference between the observative and predictive results. SNEDDS was found capable of loading 25.0 mg of secang heartwood methanolic extract in each system, with a particle size of 23.2 nm, a polydispersity index of 0.142, and zeta potential of +20.8 mV.
Pengaruh Berbagai Parameter Ekstraksi dalam Pemisahan Unsur Tanah Jarang dengan Metode Emulsion Liquid Membrane (ELM) Handias Meilinda; Novi Noviyanti; Anni Anggraeni; Diana Hendrati; Husein H Bahti
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): Maret
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.38683.1-9

Abstract

Unsur Tanah Jarang (UTJ) adalah 15 elemen kelompok lantanida, ditambah skandium dan itrium yang termasuk kelompok aktinida. UTJ memiliki banyak manfaat di berbagai bidang. Sifat fisik dan kimia yang mirip antar UTJ membuatnya sulit dipisahkan sehingga pemisahan UTJ menarik dipelajari dengan berbagai macam metode, salah satunya adalah dengan menggunakan Emulsion Liquid Membrane (ELM). ELM merupakan metode pemisahan yang dikembangkan dari ekstraksi pelarut terdiri dari tiga fase, yaitu fase eksternal (fase umpan) yang berisi UTJ yang akan dipisahkan, fase internal (fase pengupasan), dan fase membran. Fase membran berisi surfaktan sebagai penstabil dan ligan yang akan membentuk kompleks dengan UTJ pada antarmuka fase umpan dan membawanya berdifusi ke dalam fase pengupasan. ELM merupakan metode efektif untuk pemisahan karena tahap ekstraksi dan pengupasan (stripping) terjadi secara bersamaan dalam satu tahap dan fase membrannya dapat digunakan kembali. Pemisahan UTJ menggunakan metode ELM dengan berbagai ligan, seperti D2EHPA, Cyanex 572, P204, dan (RO)2P(O)OPh-COOH dipengaruhi oleh berbagai parameter, seperti konsentrasi ligan, pH fase umpan, waktu pengadukan ekstraksi, kecepatan pengadukan ekstraksi, rasio fase umpan, konsentrasi fase pengupasan, konsentrasi surfaktan, dan konsentrasi fase umpan. Parameter tersebut diseleksi untuk mendapatkan kondisi optimum sehingga meningkatkan efisiensi ekstraksi dan pengupasan yang berbeda.Effect of Various Parameters in Separation of Rare Earth Elements using the Emulsion Liquid Membrane (ELM) Method. Rare Earth Elements (REEs) are 15 elements of the lanthanide group, plus scandium and yttrium, which belong to the actinide group. REEs have many benefits in various fields. Similar physical and chemical properties between REEs make it difficult to separate, thus REEs separation is interesting to study by various methods, one of which is by using an emulsion liquid membrane (ELM). ELM is a method developed from solvent extraction consisting of three phases: the external phase (feed phase) which contains REEs to be collected, the internal phase (stripping phase), and the membrane phase. The membrane phase contains surfactants as stabilizers and ligands which will form complexes with REEs in the feed phase and are designed to diffuse into the stripping phase. ELM is an effective method to involve because extraction and stripping occur together in one glass and the membrane phase can be reused. Separation of REEs using the ELM method with various ligands, such as D2EHPA, Cyanex 572, P204, and (RO)2P(O)OPh-COOH influenced by various parameters, such as ligand concentration, feed phase pH, extraction stirring time, extraction stirring speed, feed phase ratio, stripping phase concentration, surfactant concentration, and feed phase concentration. These parameters are selected to obtain optimum conditions thereby increasing the efficiency of different extraction and stripping. 

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