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International Journal of Cardiovascular Practice
Published by Shahid Beheshti University of Medical Sciences
ISSN : 24767174     EISSN : 2476468X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
International Journal of Cardiovascular Practice(IJCP) is an international quarterly journal dedicated to a broad spectrum of topics in cardiology. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online followed by printed hard copy.
Arjuna Subject : -
Articles 198 Documents
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Serum Cortisol Level as a Predictor of In-Hospital Mortality in Patients Undergoing Primary Percutaneous Intervention for ST Segment Elevation Myocardial Infarction M Sudhakar Rao; Tom Devasia; Hashir Kareem; Padmakumar R; Ashwal AJ
International Journal of Cardiovascular Practice Vol. 4 No. 2 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29252/ijcp-24650

Abstract

Introduction: Various laboratory markers have been proposed to assess prognosis in myocardial infarction. Serum cortisol is one such laboratory marker. There are only few studies done in the recent past which prove that cortisol is a prognostic marker in STEMI.Methods: We studied a total of 168 patients who presented with STEMI and underwent primary percutaneous intervention (PPCI) within 12 hours of symptom onset between April 2016 and November 2016.Results: The average age of study population was 61 ± 0.12 years. Males were predominant (n = 132, 78.57%). 155 patients survived, whereas 13 patients died in the hospital. Mean syntax score was 16.65 ±5. 33 among patients who died, whereas it was 13.11 ± 5.62 among survivors (P = 0.03). Mean cortisol was significantly higher among the patients who died (46.13 ± 14.61 mcg/dl) than the survivors (31.16 ± 13.16 mcg/dl) (P = 0.003). The ROC AUC for in-hospital mortality was 0.77 (95% confidence interval [CI], 0.645–0.897). An optimal cut-point identified from the ROC curve was a random serum cortisol concentration of 33.66 mcg/dl, with corresponding sensitivity and specificity of 69.2 % and 64 %, respectively. At a cut-point of 29.55 mcg/dl, sensitivity and specificity were 84.6 and 50 %, respectively.Conclusion: This study showed that serum cortisol level is a strong predictor of mortality in patients undergoing PPCI for STEMI. Levels more than 33.66 mcg/dl can predict mortality with a sensitivity of almost 70 percent and specificity of 64 percent.
Thrombophilia in Pregnancy Cristina Hotoleanu
International Journal of Cardiovascular Practice Vol. 4 No. 1 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21859/ijcp-404

Abstract

Pregnancy represents a physiologic hypercoagulable state. The presence of inherited thrombophilias (factor V Leiden, prothrombin G20210A mutation, deficiencies of protein C, protein S and antithrombin) or acquired thrombophilias (antiphospholipid syndrome) increases the risk for venous thromboembolism, which represents one of the most common causes of direct maternal death. The clinical diagnosis of thrombosis can be difficult because of the overlap of symptoms with pregnancy-related manifestations. Antiphospholipid syndrome is correlated with early and late pregnancy complications whereas the association between the inherited thrombophilias and adverse pregnancy outcomes is still controversial. The psychological impact of thrombophilia in pregnancy should be also taken into consideration to prevent the negative effects of anxiety and stress on mother’s health and on birth outcomes. Thrombophilia testing in pregnancy is recommended only in cases in which the result is likely to influence the therapeutic decision. Low-molecular-weight heparins are the preferred anticoagulant for prophylaxis and therapy of thromboembolic events in pregnancy, presenting a low incidence of side effects. Future research is required to establish the optimal therapeutic strategy in pregnant women with thrombophilia, based upon a better stratification, in order to prevent thromboembolism and to improve pregnancy outcomes.
Superselective Angioembolisation: A Report of Two Rare Cases of Hemoptysis Mohammad Sadegh Keshmiri; Babak Sharifkashani; Alireza Serati; Seyed Reza Seyedi; Farah Naghashzadeh; Siroos Salehi; Omid Dehghan
International Journal of Cardiovascular Practice Vol. 4 No. 1 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21859/ijcp-402

Abstract

Superselective bronchial embolization is recently performed with a high success rate. The current study aimed at discussing the procedure and reporting two cases underwent embolization in the Masih-Daneshvari Hospital, a large center for this procedure, in Iran.
Short-and Long–Term Follow–up in the Elderly Patients With ST–Elevation Myocardial Infarction Receiving Primary Angioplasty or Thrombolytic Therapy Mohammad Kazem Kazemi; Khalil Alimohammadzadeh; Ali Maher
International Journal of Cardiovascular Practice Vol. 4 No. 1 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21859/ijcp-403

Abstract

Introduction: The ischemic time serves as the most important parameter for treatment choice in patients with ST–elevation myocardial infarction (STEMI). The current study aimed at comparing the short– and long–term follow–up of elderly patients with STEMI undergoing primary angioplasty (PCI) or thrombolytic therapy.Methods: The current cross sectional study was conducted on all patients aged >65 years, admitted to the emergency department of Imam Hossein Hospital, Tehran, Iran from January 2014 to July 2016, diagnosed with STEMI . The demographics, medical history, family history, and mediation history were recorded for all patients. Patients received PCI or thrombolytic therapy based on the ischemic time and the treatment outcome and the following events were recorded. Patients were contacted after six months and data of their death or used treatments were recorded. All data were compared between the groups.Results: Of all patients, 38 subjects received thrombolytic therapy and 62 PCI. There was no significant difference between the groups in terms of mean age and gender (P=0.5 and 0.1, respectively). The frequency of positive medical history and smoking did not differ between the groups. There was no difference in the mean values of vital signs or serum parameters, mean ischemic time, left ventricular ejection fraction (LVEF), frequency of pulmonary emboli, cardiogenic shock, the involved vessel, and post-treatment complications between the groups (P>0.05). Of the 14 cases that died after six months, five were in the thrombolytic therapy group and nine in the PCI group (P=0.8). Mean hospital stay was not different between the groups (P=0.5).Conclusions: The results of the present study on two groups with similar demographics showed no significant difference between the groups in terms of the short– and long–term follow–up of PCI and thrombolytic therapy. The results indicated the appropriateness of treatment choice based on ischemic time and the available methods.
9P21.3 locus; An Important Region in Coronary Artery Disease: A Panel Approach to Investigation of the Coronary Artery Disease Etiology Soodeh Omidi; Fatemeh Ebrahimzadeh; Samira Kalayinia
International Journal of Cardiovascular Practice Vol. 4 No. 2 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29252/ijcp-25001

Abstract

Coronary artery disease (CAD) is a disease of major concern worldwide. It is the main cause of mortality in many societies and improving the understanding about the CAD mechanism, progression and treatment, is necessary. Recent discovery of genetic factors underlying CAD has improved our knowledge of the disease in support of well-known traditional risk factors. Genotype-environment interaction is known as the main risk factor. Loci on many different chromosomes have been identified as a risk factors that increase CAD susceptibility. Here we performed a comprehensive literature review pinpointing hotspot loci involved in CAD pathogenicity. The 9p21.3 locus is the most common region associated with CAD and its specific structure and function have been remarkable in many studies. Moreover, the variations in the 9p21.3 locus have been implicated in CAD patients in different populations around the world. According to conclusions from this the 9p21.3 locus can be the first point of focus in etiology investigations of CAD patients.
Pulmonary thromboemboli in smokers and nonsmokers; Risk factors and anatomic disturbution of emboli in CT angiographies Mehdi Pishgahi; Leila Zarei; Pegah Mohaghegh; Rama Bozorgmehr
International Journal of Cardiovascular Practice Vol. 4 No. 2 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29252/ijcp-25213

Abstract

Introduction: Recognition of risk factors in different high-risk groups such as smokers in comparison with non-high risk groups would help to develop good preventive strategies for pulmonary thromboemboli (PTE). The purpose of this study was to investigate and compare clinical findings and risk factors in smoker and nonsmoker patients with pulmonary thromboembolism and assessing anatomical variant in pulmonary computerized tomography angiographies.Methods: In this descriptive study 260 consecutive patients suspected to have PTE underwent pulmonary computerized tomography angiographies in a training hospital since 2015 to 2018. Patient with documented PTE were enrolled. Clinical finding and risk factors were determined and compared between them.Results: From 260 patients 172 subjects (66.15%) had PTE and enrolled in the study. Fifty-six (32%) were smoker and 116 (68%) non-smoker. The smoker group was younger and male gender was more predominant. Oxygen saturation and inspired oxygen partial pressure differed between smokers and non-smokers (P < 0.05). The predisposing factors of thromboembolism and anatomic distribution of emboli were the same in smokers and non-smokers.Conclusion: Regarding different factors responsible for PTE in smokers and non-smokers, clinical presentation and anatomic distribution of PTE are comparable.
Prevalence of Coronary Artery Disease and Its Risk Factors in Patients Undergoing Permanent Pacemaker Implantation Ashwal Adamane Jayaram; Jerry Iype; Deeksha Karkera; Sudhakar M Rao; Tom Devasiya; Padmakumar Ramachandran; Umesh Pai; Jyothi Samanth; Ganesh Paramasivam
International Journal of Cardiovascular Practice Vol. 4 No. 2 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29252/ijcp-25262

Abstract

Introduction: Some pacemaker implanted patients have an atherosclerotic disease which promotes conduction system ischemia and conduction disturbances. The aim of this study was to determine prevalence of coronary artery disease (CAD) and its risk factors in patients undergoing permanent pacemaker implantation (PPI).Methods: This prospective, single-center hospital based study examined patients older than 40 years who required PPI. Presence of atherosclerotic risk factors and CAD was examined.Results: Of 258 patients undergoing PPI, CAD was present in 50 (19.37 %) patients. CAD was more common among middle age and elderly patients (P = 0.03). Patients older than or equal 76.5 years had specificity of 78.8% for an association with CAD. Multivariate analysis showed that age (odds ratio: 1.042; 95% confidence interval: 1.009–1.075; P = 0.01) and diabetes (odds ratio: 3.437; 95% confidence interval: 1.618–7.303; P = 0.001) had a statistically significant association with CAD. Of 169 patients with involvement of the atrioventricular (AV) node, 28 (16.6 %) had associated left anterior descending artery (LAD) involvement with P = 0.01, suggesting an association between LAD disease and chronic degenerative changes in the AV node.Conclusion: CAD was present in 19.4% of patients undergoing PPI. Age and diabetes had a strong association with CAD. LAD stenosis was significantly more prevalent in AV nodal/ infra-hisian disease compared with sinus nodal disease.
Coronary Vasospasm after Giving Adenosine for Supraventricular Tachycardia Mohit Naredi; Anil Bharani
International Journal of Cardiovascular Practice Vol. 4 No. 2 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29252/ijcp-26080

Abstract

Palpitations due to supra-ventricular tachycardia are a common mode of presentation to the emergency department. A 12 lead electrocardiography usually leads to immediate diagnosis and prompt management of this condition. Adenosine injection is the treatment of choice for rapid termination of supra-ventricular tachycardia which is widely used. It is generally considered safe and serious side effects are rare. We presented a rare case of a post-menopausal female admitted with supra-ventricular tachycardia and after injection of Adenosine, chest pain with a transient elevation of ST segment occurred. The ST segment changes reverted back to normal after a few minutes spontaneously without any therapy. This phenomenon could be explained due to coronary vasospasm produced by Adenosine. A review of literature revealed anecdotal cases of adenosine induced possible coronary vasospasm.

Page 20 of 20 | Total Record : 198

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