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Buletin Farmatera

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Published by Universitas Muhammadiyah Sumatera Utara

ISSN : 2528410X EISSN : 2528410X DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 6 Documents

Search results for , issue "Vol 4, No 3 (2019)" : 6 Documents clear

THE EFFECTIVITY OF THE ETHANOL EXTRACT OF EGGPLANT (SOLANUM MELONGENA L.) PEELS AS ANTIMALARIAL TO MONOCYTE IN MICE (MUS MUSCULUS) INDUCED BY PLASMODIUM BERGHEI Ari Widiyantoro
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Malaria is a disease caused by Plasmodium that is transmitted to humans by the bite of the female Anopheles mosquito. Malaria can be treated with antimalarial drugs such as chloroquine and artemisinin, but in some endemic areas, it is reported that parasitic resistance to chloroquine was reported so that malaria eradication becomes increasingly difficult. The occurrence of this resistance causes the need for new antimalarial findings. Eggplant (Solanum melongena L.) has many secondary metabolites, one of which is solanidine which is toxic to bacteria, fungi, viruses, and protozoa. Eggplant peel was extracted by maceration method using 70% ethanol. The analysis of secondary metabolites from the ethanol extract of eggplant peels used tube test and thin-layer chromatography. The level of parasitemia and the number of monocytes were calculated from blood smear of mice (Mus musculus) which were treated with extracts at a dose of 0.075 mg/20 g of body weight; 0.15 mg/20 of body weight; and 0.3 mg/20 g of body weight. 3.744 mg/20 g of body weight Dihydroartemisinin-Piperaquine (DHP) was used as positive control and distilled water was used as the negative control. Ethanol extract of the eggplant peels contains groups of alkaloids, flavonoids, terpenoids, steroids, phenolic, and saponins. 0.075 mg/20 g body weight of ethanol extract of the eggplant peels effectively reduces parasitemia and 0.3 mg/20 g body weight of ethanol extract of the eggplant peels effectively increases the number of monocytes in mice. There is no correlation between an increase in the number of monocytes and a decrease in the level of parasitemia. Keywords: antimalarial, eggplant, monocyte, Plasmodium berghei, Solanum melongena L.

THE IMPACT OF LONGER WORKING TO MERCURY LEVEL (HG) IN BLOOD OF THOSE TRADITIONAL GOLD MINERS AT DESA PANTON LUAS KABUPATEN ACEH SELATAN Syafruddin Din
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

It is seen traditional gold mining workings where there use mercury to process out amalgamation has been done for more than 4 years already at Desa Panton Luas. This paper is to determine the impact of longer work with Mercury level existed in the blood of those mining workers with traditional gold miners on the location. This paper is descriptive research and found that the mercury level existed in blood for a working period of average a year noted 5.57 ppb, for 2 years average noted 6.52 ppb, in three years average 7.34 ppb, and for 4 years average noted 8.95 ppb. As has been conducted in statistical test analysis indicated that there is a difference between a long-time off work in a year to 4 years serving with p < 0.05. Still, an existing difference of increasing mercury level in blood with a long time of one, two, three and four years serving in the field but it is threshold value as recommended by WHO namely 5-10 ppb. Keywords: mercury blood level, long duration of working, gold mining

PREDICTORS OF IN-HOSPITAL LENGTH OF STAY IN NSTEMI PATIENTS Ahmad Handayani; Andika Sitepu; Faisal Habib
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

As our population grows older, the rate of NSTEMI patients is rising. Risk stratification is an important process for patients with Non-ST Elevation Myocardial Infarction (NSTEMI). Global Registry of Acute Coronary Events (GRACE) scores in the best to predict mortality and myocardial infarction in NSTEMI Patients. On the other hand, NSTEMI Patients trends to be older with more co-morbidity. In this scenario, we need to predict the length of stay as it correlates with the patient's prognostic and cost. This study aims to analyze factors influencing the in-hospital length of stay in survivor NSTEMI Patients in four different hospitals (Adam Malik Medan National General Hospital, Pirngadi Medan General Hospital, Grandmed Lubuk Pakam General Hospital, and Aceh Tamiang Public General Hospital). This was an observational study with prospective design conducted on 44 patients in four different hospitals from March to May 2017. We only included the patients that discharged alive from the. hospital Statistical analysis was performed to assess the routine clinical and laboratory variables relations with the length of stay. Prolong length of stay was defined as more than 5 days. As mentioned in the previous study, older age, heart failure will prolong the length of stay. The limitations of this study were we didn't analyze the effect of revascularization, the co-morbidities, and the method of patient’s payment. We should use GRACE and TIMI risk score routinely, optimizing therapy for heart failure and giving special attention to elderly patients in NSTEMI Patients.Keywords: NSTEMI, GRACE, Length of Stay

THE DIFFERENCE BETWEEN THE EFFECTS OF CONTINUOUS RUNNING AND INTERVAL RUNNING TRAINING METHODS ON MAXIMUM OXYGEN VOLUME (O2) OF FOOTBALL ATHLETES AT EDUCATION CENTERS AND STUDENT TRAINING (PPLP) ACEH PROVINCE Hadi, Amirul
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

The increase in aerobic exercise is influenced by cardiovascular performance, so to improve aerobic exercise it is necessary to increase the VO2 Max value. The purpose of this study is to prove the differences in the effect of continuous running and interval running exercises on VO2 Max in soccer athletes in PPLP Aceh Province. This study used analytic experimental with pre-test and post-test design. The study was conducted at the Harapan Bangsa Stadium in Banda City with a sample of 52 soccer athletes. Data analysis using Independent Sample T-Test. The result is there was an overall difference between continuous running practice and interval running for VO2 max PPLP soccer athletes in Aceh Province. The average VO2 max with the continuous running method exercise is 61.9 better than the running interval is 54.9. Sig value (2-tailed) VO2 max data is 0.001 This means that there was a difference between continuous running and interval running exercises. From these results, it can be concluded that to improve the VO2 max of a professional soccer athlete, training with the continuous running method is recommended compared to the interval running training method.Keywords: Continuous running, Interval running, and VO2 Max

EFFECTIVENESS OF PREEMPTIVE ANALGESIA IBUPROFEN 10 MG / KGBB PER ORAL FOR POSTOPERATIVE PAIN MANAGEMENT IN CHILDREN UNDERGOING MASS CIRCUMCISION Muhammad Jalaluddin Assuyuthi Chalil
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Management of post-mass circumcision pain is often overlooked and not optimal because the administration of analgesia will be given when circumcision is complete. This study aims to determine the effectiveness of oral 10 mg / KGBB ibuprofen as preemptive analgesia for the management of post mass circumcision pain. After obtaining permission from the ethics commission of the FK UMSU clinical research, a prospective double-blind randomized controlled clinical trial was conducted on 28 children in consecutive sampling who met the inclusion and exclusion criteria. Samples were randomized into 2 groups, A was given ibuprofen 10 mg/kg BW orally 1 hour before incision and B was given ibuprofen 10 mg/kg BW orally at the time immediately after the circumcision was completed. Pain scale measurements were performed using FPR-S (Faces Pain Scale-Revised) at the 1st, 2nd, 4th, 6th and 8th postoperative hours. Monitoring of the 1st to 4th hours is carried out at the location of the activity, while the 6th to 8th hours are carried out by telephone. There was a significant decrease in pain scale at the 1st hour (p = 0.031) in group A. At the second to eighth-hour monitoring, the effectiveness of the two methods was the same. In conclusion, the method of preemptive analgesia is effective for the management of post-mass circumcision pain.Keywords: preemptive analgesia, post-circumcision pain

ASSOCIATION OF PPARΑ INTRON 7 G/C (RS4253778) POLYMORPHISMS WITH MUSCULAR ENDURANCE AMONG SOCCER SCHOOL STUDENTS IN MEDAN Roy Wilson Sihaloho; Yahwardiah Siregar; Maya Savira
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Peroxisome proliferator-activated receptor alpha (PPARα) is the transcription factor gene that regulates lipid metabolism and glucose homeostasis of energy within the mitochondria. PPARα gene Intron 7 variation is associated with the phenotype of human performance. Homozygous GG is more often found among athletes concerning muscular endurance. This study aims to investigate the association of PPARα polymorphism with muscular endurance. Samples from buccal cells were collected from 77 boys (aged 11-16 years). PPARα Intron 7 polymorphism was examined using PCR-RFLP with restriction enzyme TaqI. Meanwhile, the Curl-Up test has been performed to determine the muscular endurance of the subjects. The relationship between PPARα Intron 7 polymorphism with muscular endurance was assessed by using Fisher’s Exact test. The study found the genotype GG and GC of 97.4% and 2.6%, respectively. Muscular endurance was shown among categories of poor (66.2%) and fair (15.6%). Statistical analysis established no association between PPARα polymorphism with muscular endurance (p = 0,564). Keywords: PPARα polymorphisms, muscular endurance, Curl-Up test

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