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INDONESIA
Indonesian Journal of Rheumatology
Published by Indonesian Rheumatology Association
ISSN : 20861435     EISSN : 25811142     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Rheumatology is a peer-reviewed open access journal on rheumatic diseases and connective tissue disorders. This is an official journal of Indonesian Rheumatology Associantion (IRA) and published twice a year since 2009. Our mission is to encourage the development of scientific and medical practice in rheumatic diseases and connective tissue disorders. This journal is self-focused on rheumatic disease and connective tissue disorders in the form of original article (extended and/or concise reports), review articles, editorial letters, leaders, lesson from memorable cases, book reviews, and matter arising. Both in clinical and laboratory including animal studies.
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Articles 8 Documents
 1 
Search results for , issue " Vol 1, No 1 (2009)" : 8 Documents clear
Risk factors for the development of knee osteoarthritis Kasjmir, Yoga I; Nasution, A R; Daud, Rizasyah
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Objective. This article presents case control study conducted at the Rheumatology Outpatient Unit, Department of Internal Medicine, Cipto Mangunkusumo Hospital. The aim of this study was to determine several risk factors for the development of knee osteoarthritis (OA) at Rheumatology out-patient unit Department of InternalMedicine, Cipto Mangunkusumo Hospital.Method. This study used a case control design. Subjects were divided into two groups, case group and control group. The case group included all patients who had kneecomplaints that fulfi lled the 1990 American College of Radiology criteria while the control group included patients randomly chosen from visitors of the RheumatologyOutpatient Unit of Cipto Mangunkusumo Hospital who did not complain of knee pain and had been proven of not suffering OA by physical and radiological examinations. A similar questionnaire was designed for both groups. After filling out the questionnaire, both groups were examined physically and radiologically. The risk factors were analyzed using logistic regression.Results. We included 127 patients in the case group and 102 in the control group. In the case group, there were 95 women (74.80 %) and 32 men (25.20%) while the control group consisted of 69 women (67.65%) and 33 men (32.35%). From the analysis of several risk factors, there were signifi cant differences between the case and control groups such as weight (p < 0.0001 df 3), prior history of overweight or obesity (x2 = 21.255, df 1, p < 0.0001), knee trauma (p = 0.0002), and kneel down activity (p < 0.0001). There was also a signifi cant difference of smoking habit between the case group and the control group (p < 0.0001). Duration of smoking cessation was also signifi cantly different between the case group and controlgroup (t = 2.315, df 45, p = 0.0252). From the multivariate analysis, it was found that age, kneel down activity, prior obesity condition, interval between knee trauma and onset of OA, smoking habit, and duration of smoking cessation had a signifi cant correlation with knee OA.Conclusion. Age, prior history of overweight or obesity, kneeling, and interval between knee trauma and onset of OA were risk factors of knee OA. Smoking was a negative risk factor for knee OA. The protective effect of smoking was infl uenced by the duration of smoking habit and the duration of smoking cessation.
Tophi which develop years before the first attack of acute gouty arthritis Hidayat, Rudy; Kasjmir, Yoga I
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Gout is a clinical disease associated with hyperuricemia and caused by the deposition ofmonosodium urate crystals in and around the tissue of joints. The course of classic gout passes through three distinct stages: asymptomatic hyperuricemia, acute intermittent gout, and advanced gout/chronic tophaceous gout.1,2 Tophi; described as accumulation of articular, osseus, soft tissue, and cartilaginous crystalline deposits; is one of clinical manifestation of chronic tophaceous gout stage, and usually developedafter 10 or more years of acute intermittent gout.1,2 Although patients have been reported with tophias their initial clinical manifestation
Correlation between serum leptin concentration and disease activity in normal body mass index premenopausal women with systemic lupus erythematosus Suarjana, I Nyoman; Kasjmir, Yoga I; Isbagio, Harry; Soegondo, S
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Background. Leptin is recognized as a cytokine-like hormone with pleiotropic actions in modulating immune responses. The role of leptin in pathogenesis of systemiclupus erythematosus (SLE) was not fully understood yet. Previous study did not fi nd the correlation between serum leptin concentration and disease activity in patients with SLE, but selection of the subjects wasn’t based on the classifi cation of body mass index (BMI) and menopausal status.Objective. To determine correlation between serum leptin concentration and the disease activity in normal BMI premenopausal women with SLE.Methods. Serum leptin concentration was measured by enzyme-linked immunosorbent assay and disease activity was scored using Mexican SLE disease activity index (Mex-SLEDAI). Spearman’s correlation coeffi cient test was used for evaluating the strength of association between leptin level and Mex-SLEDAI score.Results. Seventy normal BMI premenopausal women with SLE were included in this study. The median of serum leptin concentration was 13.4 (0.6 – 45.9) ng/ml.The median serum leptin concentration in patients with active disease was 12.4 (0.6 – 41.6) ng/dl, whereas in patients with inactive disease was 15.2 (3.9 – 45.9) ng/dl.No signifi cant different was found between serum leptin concentration in active and inactive disease (p = 0.14). A weak negative correlation was observed between leptinconcentration and Mex-SLEDAI score, but not statistically signifi cant (r = -0.22; p = 0.07).Conclusion. No correlation was found between serum leptin concentration and disease activity in normal BMI premenopausal women with SLE. Prednisone doses anddisease duration might interfere.
Avascular necrosis of the right femoral head in a systemic lupus erythematosus patient Manuaba, Ida Ayu Ratih Wulansari; Setiyohadi, Bambang
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

According to the 1993 Association Research Circulation Osseous, idiopathic avascular necrosis of the femoral head is defined as the presence of disease or other causes that result in ischemic osteonecrosis of the femoral head without the presence of trauma or sepsis. Based on the above defi nition, idiopathic avascular necrosis(AVN) includes those that are the result of steroid administration, systemic lupus erythematosus, alcoholic consumption, etc. The pathogenesis of AVN is still obscure; however, it is basically caused by vascular circulation disorder, cell death and decreased capability of bone repair.1,2 Systemic lupus erythematosus (SLE) is characterized by the presence of systemic immune dysregulation, autoantibody formation, immune complex in the circulation, and activation of the systemic complement. The pathology during recurrence of SLE, among others, is the presenceof vascular lesion in the form of infl ammation, thrombosis, endothelial injury in which the three of them are predispositions for atherosclerosis. The vascular lesion will cause microcirculation damage which is a risk factor for the occurrence of AVN in activation of SLE. Besides being caused by vascular lesion during activation of SLE, AVN is also triggered by fat deposition in SLE patients as a result of long term steroid therapy that causes abnormal blood fat level.1,2 Patients with SLE who have undergone pharmacologic treatment with systemic steroid either in oral or injection form will have 10 to 40 times the risk of having idiopathic AVN. High dose of systemic steroid treatment of more than 4000 mg of prednisone administered for more than three months or low dose of oral steroid administered for seven days can become a risk factor for AVN. The mechanism of AVN caused by steroid treatmentis associated with hypercoagulation, fi brinolysis disorder, and thrombosis of the bone vein.1,2,3 We report a case of AVN of the right femoral head in an SLE patient.
Role of leptin in the pathogenesis of systemic lupus erythematosus Suarjana, I Nyoman
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Leptin is a 16 kDa adipocyte-secreted hormone that regulates weight centrally and links nutritional status to neuroendocrine and immune functions. Several studies indicate that leptin plays an important role in immune responses. Leptin affects both innate and adaptive immunity. It can stimulate dendritic cells (DC), monocytes, macrophages, neutrophils and natural killer cells. Leptin is involved in DC maturation and survival,and can skew the cytokine balance of a T helper (Th)1 profi le. In adaptive immunity, leptin can promote naïve T cell survival and production of interferon-γ and interleukin-2, and activate Th1 cells while inhibiting Th2 cells. Leptin may play an important role in theregulation of the Th1/Th2 balance. As a survival factor, leptin has been shown to suppress B cell apoptosis. The role of leptin in the pathogenesis of systemic lupuserythematosus (SLE) is not fully determined yet. This review tries to link the role of leptin in immunity to the pathogenesis of SLE.
Knee arthritis in an HIV positive patient - not associated with antiretroviral therapy Suarjana, I Nyoman; Kasjmir, Yoga I; Setiyohadi, Bambang
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Human immunodefi ciency virus (HIV)-associated arthritis is an oligoarthritis which predominantly affect the knees and ankles. It tends to be selflimited and to last less than six weeks. However, some patients with HIV-associated arthritis have been reported to have a disease course of more than six weeks with joint destruction. Synovial fl uid cultures are typically sterile and radiographs of the affected joints are usually normal except in those rare patients with a prolonged duration of symptoms in whom joint-space narrowing can occur.1,2 The pathophysiology of HIV specific arthritis types is not fully understood but drugs of the highly active antiretroviral therapy, in particular indinavir, are supposed to cause arthritis or rheumatological complaints.3 However,recently both human T-lymphotropic virus (HTLV) type I and HTLV-II have been suggested to induce infl ammatory or autoimmune reactions which can increase signifi cantly the incidence of arthritis.4 We report a patient with HIV infection presenting as knee arthritis which was apparently not associated with antiretroviral therapy.
Risk factors of osteoarthritis that reduce the Steinbrocker’s functional capacity of patients with osteoarthritis of the knee Setiyohadi, Bambang; Nasution, A R; Isbagio, H
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Objective. This study was implemented to determine the risk factors of osteoarthrosis which potentially could reduce the Steinbrocker’s functional capacity (SFC) of patients with osteoarthrosis of the knee.Method. In this cross sectional study, the cases were taken consecutively from the ambulatory patient with the osteoarthrosis of the knee who visited the rheumatologyclinic, Cipto Mangunkusumo Hospital. Subjects was interviewed to record the existing and severity risk factors using a structured questionnaire regarding their age, gender, duration of the illness pattern of smoking history of diabetes mellitus, menopause, body mass index (BMI), knee joint deformity, 15 meters walking time and KellgrenLawrence radiologic index.Results. One hundred thirteen cases of osteoarthrosis of the knee were assigned to the study between July to December 1992, 24 patients were male and 89 werefemale. Eighteen patients were designated to SFC I, 77 patients to SFC II, 14 patients to SFC III and 4 patients to SFC IV. With the logistic regression analysis, it was found that the signifi cant risk factors of developing SFC II, III and IV from patients of SFC I were being female and smoking. In the second logistic regression analysis we found that the signifi cant risk factors for developing SFC III and IV from patients of SFC I and II were age and BMI.Conclusion. In this study we have found that age, smoking, female genders, and BMI were the risk factors which potentially could reduce the SFC of patients withosteoarthrosis of the knee.
Systemic sclerosis in two generations family: a mother and offspring Nilasari, D; Hamijoyo, Laniyati; Kasjmir, Yoga I; Setiyohadi, Bambang
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

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Abstract

Systemic sclerosis (SSc) is uncommon connective tissue disease characterized by a pathological thickening and tethering of the skin and involvement of internal organ (i.e gastrointestinal tract, heart, lungs, and kidneys). Systemic sclerosis seems to result from a multifactorial process (alteration of the immune system, genetic, and  environmental factors) but its pathogenesis remains unclear. A familial history of SSc represents an important risk factor for developing the disease.1 We describe two generations family who developed SSc.

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