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INDONESIA
Indonesian Journal of Rheumatology
Published by Indonesian Rheumatology Association
ISSN : 20861435     EISSN : 25811142     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Rheumatology is a peer-reviewed open access journal on rheumatic diseases and connective tissue disorders. This is an official journal of Indonesian Rheumatology Associantion (IRA) and published twice a year since 2009. Our mission is to encourage the development of scientific and medical practice in rheumatic diseases and connective tissue disorders. This journal is self-focused on rheumatic disease and connective tissue disorders in the form of original article (extended and/or concise reports), review articles, editorial letters, leaders, lesson from memorable cases, book reviews, and matter arising. Both in clinical and laboratory including animal studies.
Arjuna Subject : -
Articles 307 Documents
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The Characteristics of Septic Arthritis Patients at Dr. Kariadi Hospital Semarang Malik, Zulfikar Alem Abdillah
Indonesian Journal of Rheumatology Vol. 17 No. 2 (2025): IJR VOL 17 No 2
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v17i2.70

Abstract

Background: Septic arthritis is an inflammatory disease caused by microbial infections such as bacteria, fungi, and viruses. Late diagnosis can lead to permanent joint damage, while overdiagnosis may result in unnecessary medical procedures. Although the incidence is relatively low, septic arthritis remains a medical concern due to its impact on joint function and patient quality of life. Determining the characteristics is needed to improve the diagnosis, treatment strategies, and prognosis of septic arthritis. Methods: This descriptive study utilized a retrospective design and was conducted on adult patients diagnosed with septic arthritis at dr. Kariadi General Hospital, Semarang, from January 2017 to August 2023. The analyzed variables included clinical manifestations, comorbidities, laboratory test results, synovial fluid analysis, synovial fluid culture, and antibiotic resistance. Results: Among the 49 patients, most were under 60 years old (67.4%) and male (61.2%). The knee joint was the most commonly affected site (87.8%) with the main symptoms such as joint pain, edema, and reduced range of motion (100%), along with inflammatory signs such as joint warmth (89.9%) and redness (83.7%). Synovial fluid analysis revealed that 53.06% of patients had cloudy and foul-smelling synovial fluid, with an average white blood cell count of 93,679.43/mm³ and a predominance of neutrophils (80.37%). Synovial fluid culture identified Staphylococcus aureus as the most common pathogen (34.7%), followed by Klebsiella pneumoniae (4.1%) and Salmonella sp. (2%). Antibiotic sensitivity tests showed Ampicillin/Sulbactam as the most effective treatment, while antibiotic resistance was observed in Gentamicin, Penicillin, and Linezolid. Conclusion: Staphylococcus aureus is the dominant pathogen, and rising antibiotic resistance remains a concern. Early diagnosis and targeted therapy are crucial for better patient outcomes.
Inflammatory Cascade in Aortic Wall: Latent Tuberculosis Complicating Takayasu Arteritis in a Young Bangladeshi Lady- The Silent Duo Gomes, Richmond Ronald
Indonesian Journal of Rheumatology Vol. 17 No. 2 (2025): IJR VOL 17 No 2
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v17i2.71

Abstract

Takayasu disease or pulseless disease is a rare chronic granulomatous panarteritis of unknown aetiology affecting large vessels, particularly the aorta and its main branches. It mainly affects females more than males with the ratio of 8:1 and in the second and third decade of life. Mechanism may be transmural fibrous thickening of the arterial walls. Takayasu arteritis is characterized by inflammation of the vessel wall, leading to occlusion of the vessel wall. It is represented with claudication, fever, and arthralgia. Clinical features are chest pain, vascular bruits, hypertension. There is indirect evidence signifying a potential link between tuberculosis (TB) and Takayasu’s arteritis (TAK); however, the exact mechanism and relationship between TAK and Mycobacterium tuberculosis (TB) remain elucidated. This case intends to highlight the association between latent TB and TAK, as early detection can avoid devastating consequences.
Avascular Osteonecrosis in Systemic Sclerosis Patient: Risk Factors and Role ofVasculopathy? Laitupa, Safarina Kharima
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): VOL 13 NO 2 2021
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v13i2.162

Abstract

Avascular Necrosis (AVN) or osteonecrosis refers to the death of osteocytes andosteoblasts. Sites such as the femoral head, the head of the humerus and themandibular with restricted access to local blood supply are particularly vulnerableto osteonecrosis. Various traumatic and non-traumatic causes of AVN are known,including systemic autoimmune diseases. Among traumatic causes, physicaltrauma, decompression sickness or radiation may be cited. In the non-traumacases, two theories are disputed: the first concerns the occurrence of anintravascular coagulation and the second one attributes the ischemia toextravascular compression. AVN has been well described in patients withautoimmune diseases such as systemic lupus erythematosus, but in systemicsclerosis (SSc) patients, there have been limited case reports and case series. Wepresent a case of a 32-year old woman with systemic sclerosis on corticosteroid andavascular osteonecrosis and elaborating possible etiologies or mechanism ofavascular osteonecrosis in SSc. 
Difference between the Decrease in P1NP Concentration and MRSS Within 3Months Treatment of Systemic Sclerosis Hanafi, Devy Priyantini
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): VOL 13 NO 2 2021
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v13i2.184

Abstract

Introduction: Systemic sclerosis is characterized by extensive and progressiveorgan fibrosis leads to organ failure and death. Progression of skin thickening is apredictor of morbidity and mortality. Due to the limitation of modified Rodnan skinscore (MRSS) sensitivity in detecting small changes in skin fibrosis, thus weproposed Procollagen Type I N-Terminal Propeptide (P1NP) as potential biomarker.This study aimed to analyze the difference between the decrease in P1NPconcentration and MRSS within 3 months treatment of systemic sclerosis.Methods: We conducted a retrospective cohort of paired numerical comparativeanalytic methods, as follow up of a study done by Vincent et al. and Dewi et al.Analyzis of MRSS changes and serum P1NP concentrations were done prior totreatment (baseline), and on week 4th, 8th and 12th treatment. Result: Fifty-ninesubjects were enrolled in the study. We analyzed the results of P1NP and MRSS at4th, 8th and 12th weeks of treatment, there was a significant decrease in meanrank of P1NP and MRSS (p=0.033 and <0.001). The effect of MRSS change wasgreater than P1NP. The highest decreasing effect of MRSS was obtained at week8th (η2 = 0.424, 42.4% decrease effect), and the largest decrease effect of P1NP wasobtained at week 12th (η2 = 0.120; 12% decrease effect). Conclusion: There was adifference in decreasing P1NP concentrations and MRSS in systemic sclerosiswithin 3 months of observation. MRSS showed a larger decrease in change thanP1NP after treatment. 
Pathogenesis, Clinical Presentations and Diagnosis of IgG4-related Disease: AReview Rahman, Perdana Aditya
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): VOL 13 NO 2 2021
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v13i2.189

Abstract

IgG4-Related Disease (IgG4RD) was identified by the International Classification ofDiseases (ICD) in 2012. Numerous diseases, including Mikulicz’s disease, Kuttner’stumor, Riedel’s thyroiditis, and Ormond’s disease, are pathologically associatedwith IgG4. Here, we present a review of the clinical presentation and pathogenesisof IgG4-associated disease. IgG4-RD term has been used to refer to a group ofdiseases involving multiple organs in which there is an abundant IgG4-positivelymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and mildto moderate tissue eosinophilia, all of which show clinically as a tumefactive lesion,usually in more than one organ. IgG4 exhibits a unique property called an unstabledisulfide bond between its heavy chain, as described by Fab-arm exchange whichenables the recombination of a single IgG4 heavy chain with other IgG4 heavychains, resulting in a bispecific antibody incapable of cross-linking and thus offorming an immune complex. IgG4-RD pathomechanism that causes serum IgG4increase and tissue IgG4-plasma-cell deposition that is pathogenic, rather than theIgG4 itself. Genetic predisposition, autoimmunity, T-cell dysregulation, infection,and dysbiosis are just a few of the underlying pathomechanisms. Clinicalsymptoms are also frequently complex and may involve many organs. Confirmationof a diagnosis required a comprehensive anamnesis and examination. 
Progressive Systemic Sclerosis with Interstitial Lung Disease Post Radio Ablationin Graves Disease's Patient: A Case Report Willheljulya, Maha Chakri
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): VOL 13 NO 2 2021
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v13i2.188

Abstract

Systemic sclerosis (SSc) is a connective tissue disease marked by degenerativemicrovascular abnormalities and immune system activation, resulting in skin andinternal organ fibrosis. The link between thyroid problems and systemic sclerosisis unknown. Although several studies have demonstrated that patients withsystemic sclerosis develop Graves' illness as the condition progresses, only a fewhave reported that Graves' patients develop progressive systemic sclerosis. It is anuncommon instance of multiple autoimmune illnesses in which SSc developsgradually after the birth of the first child and the patient had Graves' disease sincethe age of 17 and had thyroid ablation 5 years ago. SSc illness has a characteristicclinical appearance, involving the skin to the rest of the body and internal organs,particularly the lungs. 
Sarcoidosis Manifested as Recurrent Pericardial Effusion with Signs of ImpendingTamponade Hamijoyo, Laniyati
Indonesian Journal of Rheumatology Vol. 13 No. 2 (2021): VOL 13 NO 2 2021
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v13i2.200

Abstract

Pericardial effusion is a fatal and life-threatening condition. If it is not addressedthoroughly, complications such as constrictive pericarditis may occur. Etiologies ofpericardial effusion varied and one of the most common etiologies is tuberculosis.Other etiologies include inflammation, malignancy or other autoimmune disordersuch as sarcoidosis. Sarcoidosis is a diagnosis of exclusion and is confirmed bybiopsy result that showed non-caseating epitheloid-cell granuloma, with no otherorganism or particles. Epidemiology of sarcoidosis in Japan is 1-2 case per 100.000patients, with the peak incidence between the age of 20 to 39 years old. We reporteda case of 37 years old woman presented to our emergency department withshortness of breath and signs of pericardial tamponade. She was previously healthywith no other significant past medical. She was first treated as a case ofextrapulmonary tuberculosis and shown no improvement with anti-tuberculosismedications. Several work ups were then done in search of other etiologies of herpericardial effusion. A biopsy form one of her abdominal lymph nodes wasperformed, which pathologically revealed sarcoidosis. She was placed oncorticosteroid and methotrexate with improvement of symptoms. One monthfollowed up showed complete resolution of her pericardial effusion. 

Page 31 of 31 | Total Record : 307

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