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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

Arjuna Subject : -

Articles 5 Documents

Search results for , issue "Vol 13, No 2 (2017)" : 5 Documents clear

The Analysis of Nutmeg Mace Essential Oil Compound Using GC-MS and Antibacterial Activity Test Toward Ecschericia coli and Staphylococcus aureus Nur ‘Aini Hidayah; Hery Muhamad Ansory; Prietta Khania Kusuma Putri; Anita Nilawati
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Isolation of essential oil from nutmeg mace by using water distillation method had been done. The content analysis of the nutmeg mace essential oil compound was done by using GC-MS. The analysis result shows that there are 4 dominant compounds they are α-pinene, sabinene, 2-β-pinen, and myristicin. The quality of nutmeg mace essential oil is seen from the ratio of oil resulted from isolation with the SNI standard. Nutmeg mace essential oil does not fulfill the SNI standard in term of specific weight. However, it contains a relatively high among of myristicin which is 30.82%. According to Agusta (2000), essential oil is a good antibacterial. The antibacterial activity test was done by using the dilution and diffusion method. The result of the dilution test could not conclude the value of KHM and KBM. The diffusion test result shows that nutmeg mace essential oil with 7.5% concentration is able to inhibit the growth of Stapylococus aureus with the average inhibition zone diameter of 9.25 mm. While on the Ecschericia coli bacteria, it has the average inhibition zone diameter of 7.375 mm.

Nanoparticle Preparation of Pentagamavunon-0 Using Medium Viscous Chitosan Matrix Cross Linked by Sodium Tripolyphosphate Through Ionic Gelation Mechanism as Anti-Inflammatory Candidate Adhyatmika Adhyatmika; Ronny Martien; Hilda Ismail
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pentagamavunon-0 (PGV-0, abbreviated), a curcumin analogue with chemical structure as 2,5-bis(4’-hydroxy-3’-methoxybenzilidin)cyclopentanone, has proven to have anti-inflammatory activity and non-ulcerogenic. However, orally PGV-0 has low bioavailability because of its low solubility. One of the strategy to improve PGV-0 solubility in order to increase bioavailability is using nanoparticle carrier. The aim of the study is to formulate chitosan-PGV-0 nanoparticles through ionic gelation mechanism cross-linked by tripolyphosphate. PGV-0 nanoparticle produced was then characterized for its particle size, morphology, zeta potential, entrapment efficiency, and stability against artificial gastric and intestinal fluids (AGF and AIF). PGV-0 nanoparticle was tested for its anti-inflammatory activity by carrageenan induced inflammatory method, and its enzymatic affinity against enzyme cyclooxygenase (COX)-1 and COX-2. Chitosan-PGV-0 nanoparticles were formulated in the combination of 0,05% PGV-0, 0,05% medium-viscous chitosan and 0,002% TPP. The nanoparticles were 144,37 + 17,41 nm amorphous particles. Amount of PGV-0 entrapped was 99,40 + 0,08 % with +3,8 + 0,27 mV in zeta potential. Stability study in AGF and AIF was shown that 99,64-99,74 % (AGF) and 99,54-99,69 % (AIF) of PGV-0 remains in nanoparticles. Chitosan-PGV-0 nanoparticles at 5 mg/kg body weight was obtain 35,47 % anti-inflammatory activity and has found to have self-affinity against COX enzyme, relatively selective to COX-2.

Comparative Evaluation of Some Commercial Clopidogrel Tablets Available in Yemen Bassam Abduh Ali; Mohammed Gameel Al-haddad; Abdullah Ahmed Areqi
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Clopidogrel is a medication to reduce the risk of heart disease and taken orally. Quality of drug characterizes the production process and every phamaceutical company strives for it but often it is very difficult to achieve. This study was to investigate quality control parameters of some marketed Clopidogrel tablets. To assess the quality, eight different marketed brands of Clopidogrel 75 mg tablets available in Yemeni market collected from different pharmacies in Hodeida city. Different quality parameters like weight variation, hardness, thickness and friability were determined according to established protocols. Then the in-vitro dissolution test, potency, disintegration time were also carried out. UV-spectrophotometer was used to determine the percentage released and assay at 218 nm. All the brands comply the requirements of Pharmacopoeia as they showed acceptable weight variation range. Friability of all brands was less than 1% and no significant differences in disintegration times as they disintegrated within 15 minutes. In case of dissolution profile, all brands except C6 showed acceptable dissolution time as they released more than 60% of drug in 45 minute. The hardness of only two brands was within the range. All brands also meet the potency specifications. This study suggested that most commercially Clopidogrel tablets in Yemen maintain the quality and comply with the pharmacopeia specifications.

Comparison of Methanol, Ethyl Acetates and Chloroform Extracts of Zingiber zerumbet (L) Smith in Larvisidal Activities on Aedes aegypti (Diptera: Culicidee) Larvae Tri Murini; Mae Sri Hartati Wahyuningsih; Tri Baskoro T.Satoto
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The resistance of mosquito larvae to conventional larvicides has been increased in the recent years. Therefore, it is necessary to develop new larvacides from natural materials. Previous studies showed that Zingiber zerumbet (L.) Smith has a potential ability as a larvicide in Artemia salina Leach and Anopheles nunestovary. Nevertheless, the use of different solvents to observe the best larvicidal activity has not been known. This study aims to assess the larvicidal activity of methanol extract, ethyl acetate, and chloroform in Aedes aegypti larvae. This is an exploratory laboratory study with the posttest-only control group. The extraction solvents used were methanol, ethyl acetate, and chloroform. Twenty-five instar larvae (III-IV) of Ae.aegypti were treated with seven different concentrations of the three Z. rhizome extracts. The mortality rate of the larvae was calculated and analyzed using probit analysis regression to obtain LC50 and LC90 values. The LC50 of the methanol, ethyl acetate, and chloroform extracts are 153.57, 185.80, 3542.03 ppm; while the LC90 are 226.59, 274.70, and 5567.24 ppm, respectively. The study suggested that the methanol extract of Z. zerumbet rhizome has the most robust larvicidal activity against third-fourth instar larvae of Ae. aegypti among other extracts.

Computational Peniclilin Derivative That is Resistant to Acid and Beta Laktamase Enzyme Hari Purnomo; Intan Setyorini K
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Penicillin is an antibiotic that is still widely used to treat infections. Some penicillin derivatives are known to have acid resistance properties such as penicillin V, ampicillin, amoxicillin and methicillin. Other penicillin derivatives have resistance to beta lactamase enzymes such as methicillin, nafsilin and cloxacillin. Computational chemistry can explain why this can occur. Groups responsible for the hydrolysis process by acids and decomposition by enzymes can be calculated elektron density, so it can be understood why derivatives that are acid resistant and others are resistant to the beta lactamase enzyme. The study was conducted by optimizing each molecule using the PM3 semi-empirical method, with a gradient of 0.01 and calculating the elektron density in the carbonyl. From the results of the study it can be concluded that the acid-resistant penicillin, elektron density of the O carbonyl amide at -0.335 in penicillin V, -0.333 in methicillin, -0.316 in ampicillin, -0.315 in amoxicillin, the four less nucleophiles than the elektron density of the O amide at Benzyl penicillin which is not acid resistant is -0,347. For penicillin which is resistant to beta laktamase, it can be concluded that the elektron density of C carbonyl lactam in nafsilin + 0.272, cloxacillin + 0.270, methicillin + 0.269 is less electrophile than penicillin which is not resistant to the beta laktamase enzyme +0.280.

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