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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

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Articles 5 Documents

Search results for , issue "Vol 14, No 1 (2018)" : 5 Documents clear

Effect of Extract Combination Tithonia diversifolia (Hemsley) A.Gray and Curcuma domestica Val. In Function of Heart and Kidney Rats of Cancer Model Angga Anugerah; Woro Rukmi Pratiwi; Mae Sri Hartati Wahyuningsih
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Both Tithonia diversifolia (Hemsley) A. Gray leaves and (Curcuma domestica Val.) rhizome have bioactive compound which are an anticancer drug candidate. However, in vivo study about the effect of those to liver function and kidney function has never been carried out. The aim to determine the effect of ethanol extract T. diversifolia (Td) and C.domestica (Cd) combination to Sprague Dawley female rats liver and kidney function which have been induced with DMBA. This research used a quasi experimental study design. There were 31 female rats divided into 6 groups; healthy group; doxorubicin group; breast cancer model; extract combination I (n=5), extract combination II (n=5), extract combination III (n=5). DMBA used to initiate breast cancer was given twice a week for 5 weeks. After palpable breast cancer was showed up, the combination extract groups were given ethanol extract combination of kembang bulan leave and turmeric rhizome twice a day for 4 weeks orally with dosage ratio 40:150 mg/kgBW, 80:150 mg/kgBW, 160:150 mg/kgBW, respectively. Doxorubicin group was given 0,032mg/20gBW intraperitoneally once a day for 4 weeks. Liver and kidney function test were conducted on day 0 and the last day with SGOT, SGPT, Ureum and Creatinine level as the parameters measured. Comparison of liver and kidney function test results between extract combination groups and control groups showed no significant difference. The parameters measured were SGOT (p=0,847), SGPT (p=0,237), Creatinine (p=0,671), Ureum (p=459). Extract combination groups compared to control groups have no significant effect to liver and kidney function.

Formulation of Betel Leaf (Piper Betle L.) Essential Oil Patch Buccal with Variation CMC-Na and Carbopol as Mucoadhesive Polimers Amitia Nice Tiensi; Tri Ratna S.; T. N. Saifullah Sulaiman
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Betel leaf (Piper betle L.) contains essential oils that have antibacterial activity. The research aimed to determine the effect of CMC-Na and carbopol concentration as mucoadhesive polymers on the physical properties of bucal patches of betel leaf essential oil and inhibition activity of bacterial Streptococcus mutans. The essential oil was extracted by distillation on steam-water method, detection of compounds by GC-MS. Patches are made by the solvent casting method, with varying levels of polymer CMC-Na and carbopol, namely: formula I (80%: 20%), formula II (60%: 40%), formula III (50%: 50%), formula IV (40%: 60%), formula V (20%: 80%). The patchs were tested on their physical properties and antibacterial assay against streptococcus mutans. The results showed that the five formulas had uniform weight, thickness, folding endurance, good swelling index, and neutral pH. Higher levels of CMC-Na could increase the weight, thickness, folding endurance, swelling index, and antibacterial activity. Formula I provides higher antibacterial activity than other formulas.

Formula Optimization and Activity Test In Vitro Lotion O/W Ethanolic Extract of Mangga Temperature (Curcuma Mangga Val. and Van Zijp) as Solar Tables Mercy Arizona; A. Karim Zulkarnain
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Intersection mango extract (Curcuma mango Val.) Has activity as a sunscreen by spectrophotometry. This study aims to determine the optimum formula lotion o/w, properties and physical stability of the optimum formula lotion o/w, and the activities of the optimum formula sunscreen lotion o/w Intersection mango extract (Curcuma mango Val.) by spectrophotometry. The optimum formula was obtained by the method Simplex Lattice Design (SLD). Responses are used to determine the optimum formula is the bonding strength and viscosity. Physical stability lotion o/w at room temperature include tests dispersive power, adhesion, and viscosity, as well as freeze thaw cycling test. Activities sunscreen lotion o/w determined by spectrophotometry to determine the Sun Protecting Factor (SPF),% transmission erythema, and% transmission pigmentation. Data were analyzed by One Way ANOVA and t test. The results showed that the optimum formula lotion o/w on a combination of 5% triethanolamine (TEA) -stearat and 5% cetyl alcohol. Lotion o/w intersection mango extracts have had the scatter 63.21 ± 2.69 cm2, the stickiness of 2.32 ± 0.15 seconds, and the viscosity of 133.5±8.05 dPas. Results of statistical analysis showed that the lotion o/w has good stability. Lotion o/w has activity as a sunscreen lotion at concentrations o/w 12.5% are indicated with an SPF value of 12.82 ± 0.16 and ineffective in the protection against erythema and pigmentation.

Potential of Anticoagulan Garlic Estract (Allium sativum) Using Lee-White Method and Blood Destruction Rahmawati Rahmawati; Muammar Fawwas; Rais Razak; Utami Islamiati
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Garlic (Allium sativum L.) contains essential oils, allicin compounds, alliin and other organosulfur compounds such as ajoene which play a role in anticoagulants. This study aimed to examine the anticoagulant activity of garlic extract using the Lee-White method and blood smear. Anticoagulant activity testing was carried out by looking at the time it took for the blood to freeze after adding garlic juice, 96% ethanol (negative control) and EDTA (positive control) and looking at the red blood cell profile under a microscope (blood smear). From the test results showed that garlic extract had anticoagulant activity in which the Lee-White method, blood control freezing for three consecutive probes occurred at 4 minutes, 3 minutes 30 seconds and 3 minutes 30 seconds; addition of 96% ethanol occurred at 4 minutes 30 seconds, 2 minutes 30 seconds and 2 minutes 30 seconds and the addition of EDTA and garlic extract did not experience blood clots. Then in the blood smear method, the red blood cells added with garlic juice look round and not in groups.

Major Metabolites of Methylripariochromene-A, a Bioactive Substance in The Leaves of Eupatorium Riparium Reg. in Male Rats Urine Subagus Wahyuono; Charles S. Vairappan; Datin Maryati Mohd.; Vera Fauziati; Purwantiningsih Purwantiningsih; Marchaban Marchaban
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Methylripariochromene-A (MRC) (1) is the principal bioactive compound isolated from Eupatorium riparium Reg. collected from the Mt. Merapi National Park. MRC was isolated from the chloroform extract of the leaves by using bioassay (BST) guided isolation method. MRC causes diuretic, reduces the blood pressure and excretes mineral from the body. This activity is comparable to a clinically used diuretic drug, furosemide. MRC is a chromene type of compound, having 2 –OCH3 groups on the aromatic ring that are possibly demethylated in vivo to give phenolic compounds well known for having antiseptic properties. This study was aimed to evaluate diuretic properties compared to furosemide, isolate and identify MRC major metabolites present in urine. If it is true, then MRC probably can be used also as anti-infectious diseases in the tractus urinary. n-Hexane extract (81% MRC) of E. riparium (1.25 g/kg bw) was applied p.o on male rats (+ 200g) and furosemide was used as a positive control of diuretic activity. Urine was collected during 48 hours, partitioned with EtOAc for 15 minutes to give EtOAc fraction at the upper layer. The EtOAc fraction was then checked by tlc with MRC as the reference standard. The major metabolites were isolated by fractionating the EtOAc fraction followed by purification using preparative tlc (fr. 4-5 and 6-7). The major metabolites obtained were identified based on their 1H- and 13C-NMR data. Diuretic effect of n-hexane extract (1.25 g/kg bw) was comparable to furosemide (8.83 mL/rat vs 8.70 mL/rat for 24 hours). The 1H- and 13C-NMR data of fr 4-5 indicated that there was not major changing in the 1H- and 13C-NMR spectra appearance compared to that of MRC, except that 1 –OCH3 group was demethylated became demethyl MRC (2) . Based on HMBC and HMQC experiments, -OCH3 at C-8 was the one demethylated. The 1H-NMR data of fr. 6-7 was similar to fr. 4-5, demethylation of one –OCH3 group on C-8 but the ether linkage in the furan ring system was broken to give 2 tentative structures (3 and 4).

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