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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Majalah Farmaseutik Pharmaceutical Reports
Rais Razak
Department Of Pharmaceutical Chemistry, Faculty Of Pharmacy, Universitas Muslim Indonesia, Makassar, 90231, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology

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ANALISIS KADAR KALSIUM (Ca) DAN MAGNESIUM (Mg) PADA KACANG METE (Anacardium occidentale.L) SECARA SPEKTROFOTOMETRI SERAPAN ATOM Rais Razak
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.117

Abstract

Analysis of Calsium (Ca) and magnesium (Mg) in the mete nut (Anacardium occidentale L.) by Atomic Absorption spectrophotometry. This research intended to determine rates  of calsium (Ca) and magnesium (Mg) in the mete nut (Anacardium occidentale L.) by means of Atomic Absorption Spectrofotometry. The research enwrap qualitative analysis. Before to be analised, first to do destruction mete nut (Anacardium occidentale L.) later on dissolved in HNO3 and HCl. Qualitative analysis used  specific reactant and quantitative analysis used atomic absortion spectrophotometry at wave length of 422,7 nm and 285,21 nm for calsium and magnesium respectively. The result of the research indicated that average rates of calsium in the mete nut (Anacardium occidentale L.) is 1055,83 mg/100 g of the sample. Average rates of  magnesium in the mete nut (Anacardium occidentale L.) is 58 mg/100 g of the sample.Key Words : Calsium (Ca) and magnesium (Mg) and Anacardium occidentale L
Potential of Anticoagulan Garlic Estract (Allium sativum) Using Lee-White Method and Blood Destruction Rahmawati Rahmawati; Muammar Fawwas; Rais Razak; Utami Islamiati
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.516 KB) | DOI: 10.22146/farmaseutik.v14i1.41927

Abstract

Garlic (Allium sativum L.) contains essential oils, allicin compounds, alliin and other organosulfur compounds such as ajoene which play a role in anticoagulants. This study aimed to examine the anticoagulant activity of garlic extract using the Lee-White method and blood smear. Anticoagulant activity testing was carried out by looking at the time it took for the blood to freeze after adding garlic juice, 96% ethanol (negative control) and EDTA (positive control) and looking at the red blood cell profile under a microscope (blood smear). From the test results showed that garlic extract had anticoagulant activity in which the Lee-White method, blood control freezing for three consecutive probes occurred at 4 minutes, 3 minutes 30 seconds and 3 minutes 30 seconds; addition of 96% ethanol occurred at 4 minutes 30 seconds, 2 minutes 30 seconds and 2 minutes 30 seconds and the addition of EDTA and garlic extract did not experience blood clots. Then in the blood smear method, the red blood cells added with garlic juice look round and not in groups.
In Vitro Activity Test of A-Glucosidase Enzyme Inhibition of Moringa oleifera L. Leaves Extract Irma Pattola; St. Maryam; Rais Razak
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.834 KB) | DOI: 10.33096/pharm rep.v1i1.155

Abstract

Diabetes Mellitus (DM) is a group of disease characterized by an increase in insulin. Moringa oleifera leaves contain chemical properties such as tannins, steroids, triterpenes, flavonoids, saponins, anthraquinones and alkaloids. These chemical compounds can affect a variety of biological activities and one of the is antidiabetic. The research aimed to study the potential of Moringa oleifera extract in relation to the a-glucosidase enzyme which is one of the transitions of antidiabetic drugs based on IC50 values. In this study moringa leaves were extracted by maceration method using 96% ethanol solvent. The inhibitory activity testing uses an ELISA (Enzyme-linked Immunosorbent Assay) reader measured at 405 nm wavelength with a comparator of the acarbose because it is an antidiabetic drug of the glucosidase enzyme inhibitor group. The results of the a-glucosidase enzyme showed that the a-glucosidase enzyme activity was inhibited by the ethanol extract of Moringa oleifera L. with C50 value 84,238 µg/mL included in the less active category.
Total phenolic and flavonoid compound of crude and purified extract of green tea leaves (Camellia sinensis) from Makassar-Indonesia Muammar Fawwaz; A. Muflihunna; Mamat Pratama; Rahmawati Rahmawati; Rais Razak; Muzakkir Baits
Jurnal Fitofarmaka Indonesia Vol 9, No 3 (2022): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i3.916

Abstract

Polyphenols are a class of chemical compounds most commonly found in plants, these compounds have many health benefits associated with the character it has. The antioxidant activity of natural materials connected by polyphenol content, which can counteract free radicals. Objective: This study aims to determine the levels of total phenolic and flavonoid in crude extracts and purified extracts of the green tea leaves (Camellia sinensis). Methods: Determination of total phenolic content was using standard gallic acid by the Folin-Ciocalteau method. Total flavonoid assay using standard reference of quercetin by Chang method. Instrument used to measure the absorbance of the reaction is a UV-Visible spectrophotometer. Results: The results obtained after the measurement indicates that the sample of crude extract and purified extract of tea leaves containing total phenolic levels 40.5 and 43.9 mgGAE/g, respectively, while the levels of total flavonoids contained respectively by 2.77 and 3.14 mgQE/g. From the results obtained it can be concluded that the green tea leaves have a total phenolic content is greater than the total flavonoid content, thus it has great potential as an antioxidant
Analysis of Vitamin C and Antioxidant Activity of Capsicum frutescens L. and Capsicum annuum L. St Maryam; Rais Razak; Muzakkir Baits; Ainun Fadhilah Salim
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46082

Abstract

Vitamin C is a nutrient that the body needs in order to increase its metabolism. This helps the body to create collagen and also act as an antioxidant. This study aims to analyze of vitamin C and the antioxidant activity of Capsicum frutescens L. and Capsicum annuum L. (curly and large chili variety), obtained from the Pinrang Regency, South Sulawesi Province. The study was carried out experimentally using the UV-Vis spectrophotometry method. The measurement of vitamin C was carried out at a wavelength of 265.667 nm while for the antioxidant activity test the maximum wavelength of DPPH was 515.961 nm. Vitamin C levels obtained in Capsicum frutescens L. and Capsicum annuum L. (curly and large chili variety), were 0.926; 0.344 and 0.281 % w/w. For antioxidant activity, the results of Capsicum frutescens L. and Capsicum annuum L. (curly and large chili variety), were 2.202; 2,260; and 2.751 ppm while the comparator vitamin C was 12.360 ppm. These results indicate that Capsicum frutescens L. has higher levels of vitamin C than Capsicum annuum L. (curly and large chili variety), while for the antioxidant activity test, the IC50 value of Capsicum frutescens L. and Capsicum annuum L. (curly and large chili variety) had less antioxidant activity than a comparison vitamin C, which means that they have strong antioxidant activity.
Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase Ahmad Najib; Rais Razak; Izzatul Fikril Mujtahid
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1059

Abstract

The investigation focused on conducting an in silico screening of chemical compounds isolated from Syzygium oblanceolatum (C.B.Rob) to identify potential bioactive compounds that could act as inhibitors of α-Glucosidase. This screening involved tectoquinone as the potential inhibitor for α-Glucosidase and employed the Autodock Vina Docking process. The target enzyme, α-Glucosidase, was used as the receptor with 20 binding sites on the enzyme receptor 1LWJ and the Autodock Vina program was utilized for this purpose. The values of ∆Gbind and the lowest RMSD were determined for each of the 20 targeted binding sites on 1LWJ, representing the free energy change (∆G) resulting from the docking. The docking results demonstrated that the free energy change (∆G) for the 20 targeted binding sites ranged from -6.346 kcal/mol to -9.720 kcal/mol. The most favorable free energy change (∆G) was observed at the 16th binding site with a value of -9.720 kcal/mol, while the highest was recorded at the 18th binding site with a value of -6.346 kcal/mol.
Co-Authors A. Muflihunna Ahmad Najib Ainun Fadhilah Salim Irma Pattola Izzatul Fikril Mujtahid Mamat Pratama Muammar Fawwas Muammar Fawwaz Muzakkir Baits Rahmawati Rahmawati Rahmawati Rahmawati ST Maryam St. Maryam Utami Islamiati