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Indonesian Journal of Chemistry

ijc
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Published by Universitas Gadjah Mada

ISSN : 14119420 EISSN : 24601578 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).

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Articles 14 Documents

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Search results for , issue "Vol 4, No 3 (2004)" : 14 Documents clear

EFFECT OF Cr(VI) IONS ON THE EFFECTIVENESS OF CHLOROPHENOL PHOTODEGRADATION Endang Tri Wahyuni; Ngatidjo Hadipranoto; Iqmal Tahir; Bambang Haryo Gatut Tamtama
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

In order to solve environmental problems due to chlorophenol compound and which is hazardous and carcinogenic, the effect of Cr(VI) ions on the chlorophenol photodegradation effectiveness has been evaluated. Photodegradation process was carried out in a closed reactor by batch sistem, by exposing the UV lamp into a solution containing chlorophenol and Cr(VI) ions for a period of time. Then the solution was analyzed by gas chromatography for determination of the residual chlorophenol concentration. In this research, the influences of reaction time, Cr(VI) ions concentration, and solution pH on the photodegradation results were also evaluated. The research results indicated that the effectiveness of the photodegradation increases when ion Cr(VI) was added. The improvement of the effectiveness is proportional with the increase of the concentration of Cr(VI) added. The effectiveness of the photodegradation is also influenced by solution pH, and the highest is reached at pH < 2. Chlorophenol photodegradation follows first order reaction. The respective rate reaction constants for chlorophenol photodegradation in the absence and in the presence of Cr(VI) ions are 4.91x 10-2 and 11.41x 10-2 hours-1

SYNTHESIS NEW POTENTIAL ANTI-INFLAMMATORY AGENT SODIUM SALT OF PENTAGAMAVUNON-0 Enade Perdana Istyastono; Rr. Sri Untari Siwi S.M.P; Andreas Asdi Utama; Supardjan A.M
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

Inflammation is the response of living tissues to injury. The process affects physiological changes such as erythema, edema, asthma and fever. Non-steroid Anti-inflammatory Drugs (NSAIDs) have been developed since they could inhibit inflammation process because of its ability to inhibit biosynthesis of prostaglandin, one of inflammation mediators, through inhibition of cyclooxigenase (COX) enzymes. Molecules, which have been reported having anti-inflammatory activity, for example, are curcumin, some curcumin derivatives and curcumin analogues. One of curcumin analogues that has been developed is pentagamavunon-0 (PGV-0) whose IUPAC name is 2,5-bis(4'-hidroxy-3'-methoxy-benzylidene)cyclo-pentanone. But PGV-0, which is like curcumin, practically insoluble in water, so it causes problems in the development. The aim of this research is to synthesize a derivative of PGV-0, a natrium salt of PGV-0 (natrium pentagamavunonate-0/Na-pentagamavunonate-0), which is hoped to have a better anti-inflammatory activity and solubility in water than PGV-0. PGV-0 was synthesized by reacting vanillin and cyclopentanone catalized by acid. Na-pentagamavunonate-0 was synthesized with PGV-0 as a starting material using an appropriate method. This research was able to synthesize new compound that was estimated as a natrium salt of PGV-0 (natrium pentagamavunonate-0/Na-pentagamavunonate-0).

PREPARATION AND CHARACTERIZATION OF POROUS ALUMINA-TITANIA AEROGEL VIA CO2 SUPERCRITICAL EXTRACTION Silvester Tursiloadi; Hiroaki Imai; Hiroshi Hirashima
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

Porous aerogel of titania-alumina were prepared by hydrolysis of metal alkoxides and supercritical extraction of the solvent. Monolithic wet-gel of 0.2TiO2-0.8Al2O3, prepared by hydrolysis of metal alkoxides in alcoholic solutions, and the solvent in wet gel was supercritically extracted in CO2 at 60oC and 24Mpa for 2h. Thermal evolutions of the microstructure of the gel were evaluated by differential thermal analysis (TG-DTA), N2 adsorption, scanning electron microscopy and X-ray diffractometer. After calcination at 500oC, the specific surface area of the gel was more than 400m2g-1. The average pore radius of aerogel, about 8nm, was about 50% of that for alumina aerogel, but about 4 times larger than that of the xerogel. The specific surface area of the aerogel was more than 200m2g-1 after calcination at 800oC. The pore size and pore volume of aerogel hardly decreased after calcinations at 800oC, although those values of the xerogel remarkably decreased after calcination up to 800oC. The thermal stability of the microstructure of porous titania-alumina is improved by supercritical extraction.

INTERACTION OF IRON(II) MIXED-LIGAND COMPLEXES WITH DNA: BASE-PAIR SPECIFICITY AND THERMAL DENATURATION STUDIES Mudasir Mudasir; Karna Wijaya; Endang Tri Wahyuni; Hidenari Inoue
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

A research about base-pair specificity of the DNA binding of [Fe(phen)3]2+, [Fe(phen)2(dip)]2+ and [Fe(phen)(dip)2]2+ complexes and the effect of calf-thymus DNA (ct-DNA) binding of these metal complexes on thermal denaturation of ct-DNA has been carried out. This research is intended to evaluate the preferential binding of the complexes to the sequence of DNA (A-T or G-C sequence) and to investigate the binding strength and mode upon their interaction with DNA. Base-pair specificity of the DNA binding of the complexes was determined by comparing the equilibrium binding constant (Kb) of each complex to polysynthetic DNA that contain only A-T or G-C sequence. The Kb value of the interaction was determined by spectrophotometric titration and thermal denaturation temperature (Tm) was determined by monitoring the absorbance of the mixture solution of each complex and ct-DNA at λ =260 nm as temperature was elevated in the range of 25 - 100 oC. Results of the study show that in general all iron(II) complexes studied exhibit a base-pair specificity in their DNA binding to prefer the relatively facile A-T sequence as compared to the G-C one. The thermal denaturation experiments have demonstrated that Fe(phen)3]2+ and [Fe(phen)2(dip)]2+ interact weakly with double helical DNA via electrostatic interaction as indicated by insignificant changes in melting temperature, whereas [Fe(phen)2(dip)]2+ most probably binds to DNA in mixed modes of interaction, i.e.: intercalation and electrostatic interaction. This conclusion is based on the fact that the binding of [Fe(phen)2(dip)]2+ to ct-DNA moderately increase the Tm value of ct- DNA

CYTOTOXIC EFFECTS OF PROTEIN FRACTION ISOLATED FROM Curcuma mangga VAL RHIZOMES AND CONTAINING RIBOSOME-INACTIVATING PROTEINS ON CANCER CELL-LINES AND NORMAL CELL Sismindari Sismindari; Retno S. Sudibyo; Endang Astuti
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

C. mangga Val. has been used as an alternative remedy for cancer in Yogyakarta. The protein fraction of C. mangga was identified to contain Ribosome-inactivating Protein which cleave supercoiled double stranded DNA in vitro. In this experiment, the protein fraction isolated from fresh, 400C dried and freeze dried C. mangga Val. rhizome was screened against HeLa, Raji cell-lines and normal mononuklear cells for cytotoxic effects. This would enable us to describe the sensitivity of the protein extract on different cell types. The level of cytotoxicity was determined on the level of LC50 which was based on the percentage of the cell death following the 24 hours incubation with the extract.The protein isolated from C. mangga Val. was able to cleave supercoiled double stranded DNA to nick circular form. This result suggested that protein contained RIPs. The highest activity was identified in the protein isolated from fresh C. mangga Val, and this was followed respectively by freeze drying and 400C drying C. mangga Val. The comparison of the cytotoxic effect showed that protein of fresh C. mangga Val produced the largest number of death cells and the most toxic was on the HeLa cell line. Moreover, the LC50 indicated that the highest cytotoxic effect was shown by protein isolated from fresh C. mangga Val. followed respectively by freeze drying and 400C drying C. mangga Val. Based on LC50, the highest cytotoxic effect of C. mangga Val was found on HeLa cell line, while similar cytotoxic effect was appear on Raji cell line and normal mononuclear cells

GROWTH RATE DISPERSION (GRD) OF THE (010) FACE OF BORAX CRYSTALS IN FLOWING SOLUTION Suharso Suharso; Gordon Parkinson; Mark Ogden
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

The growth rates of borax crystals from aqueous solutions in the (010) direction at various flow rates were measured. The observed variations of the growth rate can be represented by a normal distribution. It was found that there is no correlation between growth rate distribution and solution flow under these experimental conditions.

REDUCTION AND OXIDATION PROCESSES OF CHROMIUM IN HUMIC ACID SUBFRACTION-SENSITIZED PHOTOCATALYST Uripto Trisno Santoso; Herdiansyah Herdiansyah; Sri Juari Santosa; Dwi Siswanta
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

The process of reduction and oxidation of soluble chromium in humic acid subfraction-sensitized photocatalyst was studied. Humic acid was extracted from peat soil sampled in Gambut District, South Kalimantan. Humic acid (HA) was fractionated to humic acid subfraction (HAS) by centrifugation method. ZnO and TiO2 were applied as the photocatalysts produced by Merck, suspended in solution of 2 g/L. Two germicide UV lamps 30 watt (Philip®) was placed in a box at 20 cm above the samples. The results showed that HA or HAS sensitized the photoreduction of Cr(VI) by photocatalyst. The low molecular weight of HAS is more effective to act as sensitizer than the high molecular weight one. The yield of the photoreduction of Cr(VI) with photocatalysts enhanced both in the presence of Fe(II) ion and HAS. UV irradiation of the MnO4- solutions containing Cr(III) induced the photooxidation of Cr(III) to Cr(VI). The presence of Fe(III) or HAS doesn't inhibit significantly. The inhibition is enhanced by the present of both HAS and Fe(II) or HAS and Fe(III). This inhibition is enhanced more by the presence of ZnO or TiO2 photocalysts.

A TRITERPENOID SAPONIN FROM SEEDS OF KOLOWE (Chydenanthus excelsus) Laode Rijai; Supriyatna Sutardjo; Husein Hernandi Bahti; Unang Supratman; Rymond J. Rumampuk; W.C. Taylor
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

A triterpenoid saponin have been isolated from n-butanol fraction of the seeds of kolowe (Chydenanthus excelsus). The structure was determined as 3-O-[β-D-glucopyranosyl(1→3)-β-D-xylopyranosyl(1→3)- β - D-glucuronopyranosyloxy]- 22α -O-(2-methylbutiroyloxyolean-12-en-15α,16α,28-tri-hydroxy. Structure elucidation was accomplished by NMR (HMBC, HMQC/HSQC, ROE, ROESY, TOCSY) methods, ESIMS, and IR spectroscopic.

STRUCTURE AND THERMAL STABILITY OF THE BENZO-15-CROWN-5 WITH LANTHANUM (III) BROMIDE COMPLEX Muhammad Idiris Saleh; Eny Kusrini; Abdulssalam Salhin; Rohana Adnan; Ismail Ab. Rahman; Bahruddin Saad; Bohari M. Yamin
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

The reaction of benzo-15-crown-5 (C14H20O5) ligand with La(NO3)3.7H2O in the presence of HBr has resulted in the production of an exotic sandwich complex, [LaC28H36Br4O10][3Br]. The crystal system is triclinic with space group P1, a = 12.5834(14) Å, b = 13.5816(16) Å, c = 13.8403(16) Å, a = 70.751(2)°, b = 66.773(2)° and g = 67.631(2)°. The cation comprises of the lanthanum atom coordinated to two crowns via three oxygen atoms from each crown in a η3-sandwich fashion. The two phenyl groups of the crown are brominated. The La-OLigand bond lengths are between 2.857(7) and 2.949(7) Å. The trianion [3Br]3- is linear with Br-Br bond lengths of 2.518(2) and 2.560(2) Å respectively. The molecule is stabilized by intermolecular interactions of the type C-H...Br to form dimers and are arranged parallel to bc face.

STUDY OF CATALYTIC CYCLISATION OF (+)-CITRONELLAL WITH Zn/γ-ALUMINA AS CATALYST Elvina Dhiaul Iftitah; Hardjono Sastrohamidjojo; M. Muchalal
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

The reaction of catalytic cyclisation of (+)-citronellal has been done using g-alumina and Zn/γ-alumina as catalysts. Zn/γ-alumina catalyst was prepared by impregnation of ZnBr2 into solid of γ-alumina in methanol as a solvent. The calcination process is performed on Muchalal reactor at 400 oC. The reactions were carried out under nitrogen gas atmosphere by mixing 5 mL sample and 1.0 g catalyst at 90-95 oC for 3 hours. The product of reaction was analyzed using GC, FT-IR and GC-MS. The reaction of cyclization of (+)-citronellal with γ-alumina catalyst did not give targeted product as well as reaction with Zn/g-alumina catalyst. Whereas, the reactions with Zn/γ-alumina catalyst gave four compounds of isopulegol stereoisomer. Conversion of (-)-Isopulegol, (+)-Neoisopulegol, (+)-Isoisopulegol and (+)-Neoisoisopulegol were 64,29%, 18,80%, 9,20% and 3,32% respectively. For that reason, the transformation of (+)-sitronelal using Zn/γ-alumina was considered to be the best catalyst. A reaction mechanism is proposed where the (+)-citronellal molecule binds to a catalyst Lewis acid site via the aldehyde oxygen and the π-electrons of the double bond. Subsequent protonation of the aldehyde via a neighbouring Bronsted acid site initiates the cyclisation to isopulegol.

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